Navigation Links
Gleevec Receives FDA Priority Review as First Therapy to Reduce Recurrence of Gastrointestinal Stromal Tumors After Surgery
Date:8/27/2008

etaminophen, warfarin, erythromycin and phenytoin. (Please see full Prescribing Information for other potential drug interactions).

For daily dosing of 800 mg and above, dosing should be accomplished using the 400 mg tablets to reduce exposure to iron.

Common side effects of Gleevec tablets

The majority of adult Ph+ CML patients who received Gleevec in clinical studies experienced adverse reactions at some time, but most were mild to moderate in severity. The most frequently reported adverse reactions (all Grades) were superficial edema (60%-74%), nausea (50%-73%), muscle cramps (28%-62%), vomiting (23%-58%), diarrhea (43%-57%), musculoskeletal pain (38%- 49%) and rash and related terms (36%-47%).*+

* Numbers indicate the range of percentages in 4 studies among adult patients with Ph+ CML in blast crisis, accelerated phase, and chronic phase.

+ For more detailed study information, please see full Prescribing Information.

The adverse reactions and safety profile for Ph+ ALL, MDS/MPD, ASM and HES/CEL were generally similar to the safety profile for Ph+ CML.

The most frequently reported drug-related adverse reactions reported in the Ph+ ALL studies were mild nausea, vomiting, diarrhea, myalgia, muscle cramps and rash, which were easily manageable. Superficial edemas were also a common finding in all studies and were described primarily as periorbital or lower-limb edemas. However, these edemas were rarely severe and may be managed with diuretics, other supportive measures, or, in some patients, by reducing the dose of Gleevec.

Frequently reported adverse reactions (all Grades) in the seven MDS/MPD patients assessed were nausea (57%); diarrhea and muscle cramps (43% each); anemia, fatigue, arthralgia and periorbital edema (29% each).

All ASM patients experienced at least one adverse reaction at some time. The most frequently reported adverse reactions were diarrhea, nausea, ascites, muscle cramps, dyspnea, f
'/>"/>

SOURCE Novartis
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9 10 11 12

Related biology technology :

1. Video: Higher Initial Dose of Gleevec Achieved Better Early Responses than Standard Dose for Patients with Chronic Myeloid Leukemia
2. TorreyPines Therapeutics Receives NASDAQ Deficiency Notice
3. Omaxe Infrastructure & Construction Private Ltd Receives LoI for Construction of Allopathic Medical College and Associated Hospital at Saharanpur, UP With Construction Value of Approx 250 Crores
4. Caliper Life Sciences Receives $1.1 Million Task Order from the EPAs ToxCast(TM) Screening Program
5. Biotest Diagnostics Receives FDA Clearance for Full Line of Traditional Blood Bank Reagents
6. BMP Sunstone Receives Production License from the SFDA to Manufacture and Market Pediatric Multivitamin Granules in the PRC
7. XTL Biopharmaceuticals Receives Notice of Non-Compliance with Nasdaq Marketplace Rule Due to Changes in Board Composition
8. CV Therapeutics Receives European Approval for the Brand Name Ranexa(R)
9. SGX - Lilly Merger Offer Receives Positive Opinions From Proxy Advisory Firms
10. Angiotech receives CE Mark approval of HemoStream(TM) Chronic Dialysis Catheter
11. Medicsight Receives Brazilian State Food and Drug Administration Approval for ColonCAD Software
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... The Workgroup for Electronic Data Interchange (WEDI), ... health IT to create efficiencies in healthcare information exchange, ... has developed an issue brief titled, “What is ... HPID Workgroup, a part of WEDI’s Strategic National HPID ... and Medicaid Services (CMS) to identify common misuse of ...
(Date:7/28/2014)... 28, 2014 Proove Biosciences , ... be exhibiting data and research conducted through their latest ... Intervention Society’s (ISIS) 22nd Annual Scientific Meeting. The ... Hyatt Regency, in Orlando, Florida. , The ... competence of physicians who care for patients suffering specificity ...
(Date:7/28/2014)... According to the ... Instruments, Services), Methods (Phenotypic, Genotypic), Applications (Pharmaceutical, Diagnostic, Environmental, ... - Global Forecasts to 2019" published by ... at $896.5 Million in 2014 and is ... growing at a CAGR of 5.9% from ...
(Date:7/28/2014)... , July 28, 2014   Propeller Health , ... announced the hire of Brad Towle as ... be responsible for driving the company,s sales growth, customer ... in healthcare, and specifically his past role in the ... the company at this pivotal time in the industry," ...
Breaking Biology Technology:WEDI’s HPID Workgroup Announces Release of Issue Brief: “What is the Difference Between a Health Plan and Payer?” 2Proove Biosciences Exhibits Industry Leading Data and Research at International Spine Intervention Society’s 22nd Annual Scientific Meeting 2Microbial Identification Market worth $1,194.1 Million by 2019 2Microbial Identification Market worth $1,194.1 Million by 2019 3Propeller Health Hires Brad Towle as Senior Vice President of Business and Client Development 2
... 13 Joseph F. Finn, Jr.,C.P.A. ("Finn"), Assignee of ... creditors, announced today that all pharmaceutical,intellectual property will be ... One of the pieces of intellectual property for ... a branded drug that currently has,more than $2 billion ...
... new research from,BioInformatics, LLC ( http://www.gene2drug.com ) -- ... life science industry -- service,providers in the life ... to,demonstrate customer value. As offerings become more diverse, ... of all three, vendors must respond to customers, ...
... the,appointment of David A. Mann to the Company,s Board ... Board,s audit committee., "Dave,s years of executive management ... an invaluable asset to Omeros,",stated Gregory Demopulos, M.D., Chairman ... our Board, and I expect that he will play ...
Cached Biology Technology:BioInformatics, LLC Offers Solutions for Optimizing Service and/or Maintenance Contracts 2BioInformatics, LLC Offers Solutions for Optimizing Service and/or Maintenance Contracts 3Omeros Appoints David A. Mann to its Board of Directors 2
(Date:7/29/2014)... has received from the National Institutes of Health ... project to support the further development of 23andMe,s ... , Specifically, the grant supports four areas ... to improve the company,s ability to identify novel ... to support the collection of a broader set ...
(Date:7/29/2014)... latest research from the University of Adelaide ... of many preterm children can perform almost as well as ... University,s Robinson Research Institute has found that as ... early life, their cognitive abilities as a teenager can potentially ... results of the study, published in this month,s issue of ...
(Date:7/29/2014)... in 100,000 people characterized by a loss of nerve ... a new study by a team of researchers at KU ... other European institutions confirms for the first time that achalasia ... in Nature Genetics , is an important step towards ... in the lower esophagus opens, allowing food to enter the ...
Breaking Biology News(10 mins):23andMe scientists receive approximately $1.4 million in funding from National Institutes of Health 223andMe scientists receive approximately $1.4 million in funding from National Institutes of Health 3Preterm children's brains can catch up years later 2Mysterious esophagus disease is autoimmune after all 2
... 14, 2011 -- The University of Miami Rosenstiel School of ... Peter Mumby is the 2011 recipient of The Rosenstiel Award, ... ecologist and professor at Australia,s University of Queensland, is the ... understand the benefits and limitations of conservation strategies for coral ...
... Ryou, researcher at the UK Sanders-Brown Center on ... genetics in the UK College of Medicine, may ... Prion diseases, which include Creutzfeldt-Jakob disease in ... in cattle, are caused by prions unconventional ...
... COLUMBIA, Mo. Plants harvest energy through the process of ... about the genes that regulate the transport of sugars to ... Missouri researcher has received a $6.6 million grant from the ... the genes that control the movement of carbohydrates in corn. ...
Cached Biology News:Peter Mumby to receive prestigious 2011 Rosenstiel Award from the University of Miami 2MU researcher leads new $6.6 million study that could lead to better corn plants 2
... Phosphatase 2 (LPP2) fractionated ... solution Solution in ... 0.08% sodium azide. unique ... human LPP2 protein. The ...
Rabbit polyclonal to Retinoic Acid Receptor beta 2 ( Abpromise for all tested applications). entrezGeneID: 5915...
Ca2+ Channel Ca gamma 2 Purified Anti-Mouse, Anti-Rat, Anti-Human clone Polyclonal, Isotype Rabbit Ig, 50 µl Consult technical datasheet for details....
...
Biology Products: