Navigation Links
Gleevec Receives FDA Priority Review as First Therapy to Reduce Recurrence of Gastrointestinal Stromal Tumors After Surgery
Date:8/27/2008

is and the National Cancer Institute (NCI). The study was led by the American College of Surgeons Oncology Group (ACOSOG).

The investigators reported that Gleevec therapy was well tolerated by most patients, with side effects similar to those observed in previous clinical trials with Gleevec. These include nausea, diarrhea and swelling (edema)(3).

About gastrointestinal stromal tumors (GIST)

Gastrointestinal stromal tumors (GIST) belong to a group of cancers known as soft tissue sarcomas. They are the most common sarcomas and can be found most often in the stomach and small intestine. The incidence of GIST is estimated to be 4,500 - 6,000 new cases per year in the US (15-20 cases per million population)(5), of which more than 90% are kit-positive(6). Kit -- also known as CD117 -- is a protein that, when mutated, has been identified as one of the major causes of GIST.

About Gleevec

Gleevec(R) (imatinib mesylate) tablets are indicated for the treatment of newly diagnosed adult patients with Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML) in the chronic phase. Follow-up is limited to 5 years. Gleevec is also indicated for the treatment of patients with Ph+ CML in blast crisis (BC), accelerated phase (AP), or in chronic phase (CP) after failure of interferon-alpha (IFN-alpha) therapy; adult patients with relapsed or refractory Ph+ acute lymphoblastic leukemia (Ph+ ALL); adult patients with myelodysplastic/myeloproliferative diseases (MDS/MPD) associated with PDGFR (platelet-derived growth factor receptor) gene rearrangements; adult patients with aggressive systemic mastocytosis (ASM) without the D816V c-KIT mutation or with c-KIT mutational status unknown; adult patients with hypereosinophilic syndrome (HES) and/or chronic eosinophilic leukemia (CEL) who have the FIP1L1- PDGFR alpha fusion kinase (mutational analysis or FISH demonstration of CHIC2 allele deletion) and for patients with HES and/or CEL who are FIP1L1-
'/>"/>

SOURCE Novartis
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9 10 11 12

Related biology technology :

1. Video: Higher Initial Dose of Gleevec Achieved Better Early Responses than Standard Dose for Patients with Chronic Myeloid Leukemia
2. TorreyPines Therapeutics Receives NASDAQ Deficiency Notice
3. Omaxe Infrastructure & Construction Private Ltd Receives LoI for Construction of Allopathic Medical College and Associated Hospital at Saharanpur, UP With Construction Value of Approx 250 Crores
4. Caliper Life Sciences Receives $1.1 Million Task Order from the EPAs ToxCast(TM) Screening Program
5. Biotest Diagnostics Receives FDA Clearance for Full Line of Traditional Blood Bank Reagents
6. BMP Sunstone Receives Production License from the SFDA to Manufacture and Market Pediatric Multivitamin Granules in the PRC
7. XTL Biopharmaceuticals Receives Notice of Non-Compliance with Nasdaq Marketplace Rule Due to Changes in Board Composition
8. CV Therapeutics Receives European Approval for the Brand Name Ranexa(R)
9. SGX - Lilly Merger Offer Receives Positive Opinions From Proxy Advisory Firms
10. Angiotech receives CE Mark approval of HemoStream(TM) Chronic Dialysis Catheter
11. Medicsight Receives Brazilian State Food and Drug Administration Approval for ColonCAD Software
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... rely on sophisticated equipment, trained personnel, and detection ... against terrorist attacks. A revolutionary new electronic chip ... their job much easier. , The groundbreaking nanotechnology-inspired ... Aviv University ,s School of Chemistry and Center ... Herzliya company Tracense, picks up the scent of ...
(Date:7/24/2014)... Yan, Distinguished Professor of Engineering at the University ... to solve problems in energy engineering, environmental sustainability ... on zeolites, porous rock with a well-defined, crystalline ... is so precisely decided that zeolites can separate ... of an angstrom (one-tenth of a nanometer), making ...
(Date:7/24/2014)... , July 24, 2014 Research ... "Global Genomics and Proteomics Analytical Instruments Market 2014-2018" ... http://photos.prnewswire.com/prnh/20130307/600769 Genomics is the study ... the study of the structure and functions of proteomes ... bioinformatics tools and technology. Genomics involves the mapping of ...
(Date:7/24/2014)... , July 24, 2014  CorMedix Inc. (NYSE ... and commercializing therapeutic products for the prevention and ... receipt of notice on July 18, 2014 from ... has accepted the CorMedix plan to regain compliance ... a result, the NYSE-MKT is continuing the Company,s ...
Breaking Biology Technology:Nano-sized chip 'sniffs out' explosives far better than trained dogs 2University of Delaware researcher describes new approach for creating organic zeolites 2Global Genomics and Proteomics Analytical Instruments Market 2014-2018: Key Vendors are Agilent, Bio-Rad , F. Hoffmann, La Roche, Illumina, PerkinElmer and Thermo Fisher Scientific 2CorMedix, Inc. Granted Extension of NYSE-MKT Listing 2CorMedix, Inc. Granted Extension of NYSE-MKT Listing 3
... , Evelyn McGown, Ph.D., Jinfang Liao, M.D., Ph.D., Molecular ... Olivier Dery, BD Biosciences Clontech, Palo Alto, CA. ... INTRODUCTION , Proteins inside eukaryotic ... balance between synthesis and degradation. Whereas protein synthesis is ...
... A. Gagne, E. Robitaille, M. Harvey, J.-A. St. Pierre, D. ... Introduction , High throughput ... process is typically highly automated and can provide screening rates over 100,000 ... simple, preferably mix and read type assays, where all reagents necessary to ...
... , This study demonstrated ... platform for a helicase functional assay. Helicase activity was measured on ... the oligos was biotinylated; the other was 5' end-labeled with [ ... a [ 33 P]-biotinylated DNA duplex substrate, then immobilized on the ...
Cached Biology Technology:Measurement of proteasome inhibition in live cells in Molecular Devices microplate fluorometers 2Measurement of proteasome inhibition in live cells in Molecular Devices microplate fluorometers 3Measurement of proteasome inhibition in live cells in Molecular Devices microplate fluorometers 4Measurement of proteasome inhibition in live cells in Molecular Devices microplate fluorometers 5Receptor Binding Assays using Fluorescence Polarization Detection: the [FP]2TM Characterized Tracers 2Receptor Binding Assays using Fluorescence Polarization Detection: the [FP]2TM Characterized Tracers 3Receptor Binding Assays using Fluorescence Polarization Detection: the [FP]2TM Characterized Tracers 4Receptor Binding Assays using Fluorescence Polarization Detection: the [FP]2TM Characterized Tracers 5Receptor Binding Assays using Fluorescence Polarization Detection: the [FP]2TM Characterized Tracers 6Evaluation of FlashPlate in a Helicase Assay 2Evaluation of FlashPlate in a Helicase Assay 3
(Date:7/25/2014)... of Adelaide has opened the way for the development of ... In Australia, annual barley production is second only to wheat ... of the most important diseases of barley. , Senior Research ... of special growths on the cell walls of barley plants ... , The research, by the ARC Centre of Excellence in ...
(Date:7/25/2014)... (SB) is a complex congenital central nervous system ... of the neural tubes during the embryonic phase. ... and fecal incontinence and neurocognitive retardation. Such problems ... of life. Researchers at Ankara Physical Medicine and ... functional performance in children with SB, using the ...
(Date:7/25/2014)... reach puberty is influenced by ,imprinted genes,a subset of genes ... This is the first evidence that imprinted genes can ... this study were published today in the journal Nature ... is a marker for the timing of puberty in females. ... between girls, is an inherited trait, and is linked to ...
Breaking Biology News(10 mins):New hope for powdery mildew resistant barley 2Could age of first period influence development of diseases in older women? 2
... the International Symposium " Nature and Governance Biodiversity Data, Science, ... 11 to 12 February. The symposium aimed at clarifying and popularizing ... Meeting held from 13 to 15 February 2013. The ... and brought together high-ranking speakers and guests from across the world ...
... chair!" That command given by countless parents to their ... a robot that is actually a computerized model of a ... a University of Iowa research program. That,s because a ... to accurately predict the role posture plays in transferring the ...
... A team of UCLA-led researchers has identified a protein ... as a weapon against deadly human pathogenic viruses such ... designated "priority pathogens" for national biosecurity purposes by the ... In a study published in the January issue ...
Cached Biology News:Virtual vehicle vibrations 2Newly identified natural protein blocks HIV, other deadly viruses 2
Mouse monoclonal antibody raised against a partial recombinant AAAS. NCBI Entrez Gene ID = AAAS...
... Cosmid Cloning Kit enables you to prepare, ... unbiased primary cosmid library of genomic DNA ... sublibraries. High efficiency cosmid library construction is ... protocols. First, genomic DNA is randomly sheared ...
Mouse monoclonal antibody raised against a partial recombinant EBI3. NCBI Entrez Gene ID = EBI3...
... VersaDoc MP 4000 System is a ... system capable of supporting a wide ... chemiluminescence, densitometry, and chemiflourescence. Red, ... imaging of multiplexed fluorescent samples, reducing ...
Biology Products: