Navigation Links
GlaxoSmithKline and Mpex Pharmaceuticals Form Alliance to Develop Novel Efflux Pump Inhibitors for Use Against Serious Gram-Negative Infections
Date:6/16/2008

- Potential to combine compounds with multiple new and existing antibiotics

to create a broad offering of anti-infective medicines with activity

against drug-resistant organisms -

SAN DIEGO and LONDON, June 16 /PRNewswire/ -- Mpex Pharmaceuticals and GlaxoSmithKline (GSK) today announced that they have entered into a worldwide strategic alliance for the discovery, development and commercialization of novel medicines for bacterial diseases. The collaboration provides GlaxoSmithKline access to Mpex's novel efflux pump inhibitors (EPI) and related proprietary technology for use in combination with a variety of antibiotics. The collaboration will focus on the discovery and development of novel drug regimens comprising Mpex's EPIs combined with GSK's novel development stage compounds as well as existing commercial antibiotics to improve potency and broaden the spectrum of antibacterial activity.

Under the terms of the agreement, Mpex will grant GlaxoSmithKline rights to product candidates developed under the collaboration that are directed to three different target product profiles and with the potential to deliver up to seven treatment options. Mpex will be responsible for the discovery of EPI drug candidates and the development of combination product candidates through clinical proof of concept, at which point GlaxoSmithKline will have an option to exclusively license each product candidate for further development and commercialization on a worldwide basis. Mpex will retain the right to further develop and commercialize product candidates for which GlaxoSmithKline does not exercise its option. Mpex will receive an $8.5 million upfront payment and a $6.5 million equity financing commitment from GlaxoSmithKline. Contingent on achieving certain milestones, Mpex is eligible to receive development, regulatory and commercial milestones ranging up to $200 to $250 million for each product candidate. If GlaxoSmithKline exercises its
'/>"/>

SOURCE Mpex Pharmaceuticals
Copyright©2008 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3 4 5

Related biology technology :

1. GlaxoSmithKline Signs Licensing Agreement With Compendia Bioscience
2. GlaxoSmithKline Named A Top Employer for Promoting Healthy Lifestyles
3. GlaxoSmithKline Commences Tender Offer to Acquire Sirtris Pharmaceuticals
4. GlaxoSmithKline to Acquire Sirtris Pharmaceuticals, a World Leader in Sirtuin Research and Development
5. Pharmacopeia to Receive $5 Million Payment from GlaxoSmithKline
6. Ingenuity Systems Extends Enterprise-Level Software Agreement With GlaxoSmithKline
7. Vaccinex Antibody Licensed to GlaxoSmithKline
8. GlaxoSmithKline Announces Data on TYKERB(R) (Lapatinib) Plus Capecitabine for the Treatment of HER2 Positive Breast Cancer Brain Metastases
9. GlaxoSmithKline Responds to JAMA Article on the ICES Thiazolidinediones and Cardiovascular Outcomes in Older Patients with Diabetes
10. GlaxoSmithKline Consumer Healthcare Recommends Maintaining FDAS Current Two-Class Drug System
11. BioWa Announces Licensing of BioWas POTELLIGENT(R) Technology by GlaxoSmithkline for Use in Antibody Research and Development
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2013)... The New Jersey chapter of the ... Processing Associates (BDPA), is hosting its 10th annual Families ... all-day event will encourage students and their parents to ... outs from many of the industries’ finest teachers. Held ... Jersey Institute of Technology, the event will include workshops, ...
(Date:5/23/2013)... 2013  Verenium Corporation (Nasdaq: VRNM ), ... and commercialization of high-performance enzymes, today announced that ... present at two upcoming conferences. (Logo: ... the Second Annual Marcum LLP Microcap Conference on Thursday, ... New York City.  The presentation is scheduled to begin ...
(Date:5/23/2013)... South Korea , May 23, 2013 /PRNewswire/ ... with SillaJen, Inc., a private biotherapeutics and contract ... targeted biological products for cancer, announced today a ... in patients treated with the oncolytic and immunotherapeutic ... This research was published in the May ...
(Date:5/23/2013)... 23, 2013 African Ancestry ... for people of African descent, today announced new ... For people of all races, myDNAmix determines various ... distinct populations: Indigenous Americas (Native American), East Asia, ... , Originally launched in late 2011, ...
Breaking Biology Technology:Black Data Processing Associates (BDPA) New Jersey Hosts 10th Annual Families in Technology Day June 8, 2013 2Verenium To Present At Two Upcoming Conferences 2Verenium To Present At Two Upcoming Conferences 3Pusan National University Announces Science Translational Medicine Publication Highlighting Landmark Demonstration of Functional Anti-Cancer Antibody Induction in Patients Following JX-594 Treatment 2Pusan National University Announces Science Translational Medicine Publication Highlighting Landmark Demonstration of Functional Anti-Cancer Antibody Induction in Patients Following JX-594 Treatment 3AfricanAncestry.com Rolls Out Improved MyDNAMix Admixture Test for People of all Races; Enhancements Increase Accuracy in Estimation of Ancestral Makeup 2AfricanAncestry.com Rolls Out Improved MyDNAMix Admixture Test for People of all Races; Enhancements Increase Accuracy in Estimation of Ancestral Makeup 3
... Inc. announced today Winchester Hospital ... of APIs suite of labor resource management solutions ... include Payrollmation time and attendance, ActiveStaffer staff scheduling, ... , ,The hospital is adopting the applications in ...
... MILWAUKEE - Merge eFilm , a global ... the release of eFilm Workstation 1.9 and ... PACS for 10 imaging centers. , ,eFilm Workstation ... the ability to view and manipulate digital diagnostic ...
... long-standing riddle of whether the Earth's ice ages occurred simultaneously ... the glacial deposits found in the high desert east of ... effects of cosmic rays on minerals found in boulders carried ... of scientists from the University of Wisconsin-Madison has demonstrated that ...
Cached Biology Technology:Glacial records depict ice age climate in synch worldwide 2Glacial records depict ice age climate in synch worldwide 3
(Date:5/22/2013)... feared Legionella pneumophila bacteria is responsible for ... In order to infect us, this pathogen has developed ... go unnoticed in our cells, thus avoiding these acting ... Basque biosciences research centre, CIC bioGUNE, in which teams ... USA and the National Supercomputation Centre in Barcelona (BSC) ...
(Date:5/22/2013)... Early screening for prostate cancer could become as ... women, thanks to UC Irvine research published today in ... , After more than a decade of work, UC ... clinically usable markers for prostate cancer in urine, meaning ... greater accuracy and at dramatically lower cost. The same ...
(Date:5/22/2013)... May 22, 2013. Plastic additives known as phthalates ... everywhere: They turn up in flooring, plastic cups, ... the Centers for Disease Control and Preventionthe bodies ... have come under increasing scrutiny. A growing collection ... can leech from packaging and mix with food) ...
Breaking Biology News(10 mins):Mechanism discovered which aids Legionella to camouflage itself in the organism 2UCI chemists devise inexpensive, accurate way to detect prostate cancer 2UCI chemists devise inexpensive, accurate way to detect prostate cancer 3Study links chemicals widely found in plastics and processed food to elevated blood pressure in children and teens 2
... Four new studies addressing basic questions about how ... by the National Science Foundation,s (NSF) Division of ... just over $1.3 million, NSF,s awards for these ... and about fundamental biological responses to environmental changes, ...
... States and United Kingdom are signing a memorandum ... atmospheric science and technology. The agreement will enable ... developing joint educational and training programs. The ... the U.S. National Center for Atmospheric Research (NCAR) ...
... devote more resources to research into the effects ... to a paper published today in the journal ... Research Flagship. ,"Marine ecosystems are undoubtedly under-resourced, overlooked ... impacts on marine life is a mere drop ...
Cached Biology News:National Science Foundation funds research addressing enduring questions of life 2National Science Foundation funds research addressing enduring questions of life 3National Science Foundation funds research addressing enduring questions of life 4US and UK research centers launch major collaboration on atmospheric research, technology 2Ocean life under threat from climate change 2
Mouse Anti-Amyloid beta [1-16], clone 6E10, Monoclonal Antibody...
... This DuoSet ELISA Development kit contains the ... sandwich ELISAs to measure natural and recombinant ... supernates and serum. Each kit contains sufficient ... 96-well plates, provided that the following conditions ...
HES-1 [Hairy 1], Available Summer 2003...
E1A (adenovirus early region 1)...
Biology Products: