Navigation Links
GlaxoSmithKline Awarded U.S. Department of Defense Contract to Pursue Novel Antibacterial Research Program

GSK Increases Research Effort to Target Drug-Resistant Gram Negative


PHILADELPHIA, Sept. 18 /PRNewswire-FirstCall/ -- GlaxoSmithKline (NYSE: GSK) today announced that it has signed an agreement with the Defense Threat Reduction Agency (DTRA) of the U.S. Department of Defense (DOD), to identify and develop a new class of antibacterials targeting both Gram negative biothreats and conventional Gram negative hospital pathogens. The agreement awards GSK up to $41 million over a five-year period, while GSK will contribute substantially to this collaborative effort by providing supplemental staff and by covering other program costs.

The research will focus on such Gram negative pathogens as Pseudomonas, Klebsiella and Acinetobacter, which are increasingly resistant to all known classes of antibiotics. These bacteria can cause a significant health threat to patients, particularly those in intensive care units. Gram negative infection is associated with an increase in morbidity, and in severe cases can lead on to septic shock and an increase in mortality. Though there are antibiotics in development from established classes, there is only one novel class systemic agent in clinical trials to address this mounting problem.

"The Department of Defense is excited about the opportunity of teaming with GSK and leveraging their capabilities and resources to develop antibacterial compounds for Gram negative biothreat agents," said Lieutenant Colonel Calvin Carpenter at the Defense Threat Reduction Agency. "This research is needed to identify and deliver antibacterials from entirely new classes to defend against potential biothreat outbreaks and hospital-acquired infections."

The challenge of developing new antibacterial treatments is compounded by the fact that Gram negative bacteria are difficult to attack because they have an outer membrane surrounding the bacterial cell wall that interferes with drug penetration. New treatments must not only be toxic to the pathogen, but must also overcome the barriers to entry into the cell.

"Through this innovative collaboration with DTRA, GSK will focus its experience and resource in drug discovery on new antibacterial solutions that address biothreat pathogens as well as conventional Gram negative infections acquired in the hospital," said Dr. David Payne, Group Director, Antibacterial Research, Infectious Diseases Center for Excellence in Drug Discovery (ID CEDD) at GSK.

With few new antibiotic classes being developed in the last 40 years and growing resistance of various types of bacteria to treatment, GSK is progressing a growing portfolio of antibiotic candidates. The ID CEDD, formed earlier this year, is exclusively dedicated to discovering and developing novel treatments for bacterial and other types of infections.

"GSK is committed to identifying and progressing novel antibacterials that address this rapidly emerging public health threat," said Dr. Patrick Vallance, Senior Vice President, GSK Drug Discovery. "This agreement with DTRA provides a substantial resource towards address the challenges of this area and will enable us to accelerate the delivery of new Gram negative antibacterials for patients."

In addition to this agreement, GSK previously announced further support for its Gram negative research program from the Wellcome Trust through their 91 million Seeding Drug Discovery initiative which aims to assist researchers and companies, small and large, to take forward early-stage drug discovery projects in small molecule therapeutics. It is intended that these projects will then be taken up for further research and development by industry.

About the Defense Threat Reduction Agency

The Defense Threat Reduction Agency (DTRA) is an agency within the U.S. Department of Defense dedicated to leveraging the latest scientific resources, expertise and capabilities to ensure the United States remains ready and able to address present and future chemical and biological threats. For more information, visit

About GlaxoSmithKline

GlaxoSmithKline -- one of the world's leading research-based pharmaceutical and healthcare companies -- is committed to improving the quality of human life by enabling people to do more, feel better and live longer. For more information and the company's product development pipeline, visit GSK at

GSK has an established heritage in the development of novel anti- infectives to meet clinical needs. GSK is committed to the discovery, development and commercialization of innovative, potent antibacterials. Our approach includes in-house research using leading technologies, as well as actively seeking in-licensing opportunities and collaborative relationships.

SOURCE GlaxoSmithKline
Copyright©2007 PR Newswire.
All rights reserved

Related biology technology :

1. GenTel acquires GlaxoSmithKline chip platform
2. Small Tree Communications awarded $2.85M defense contract
3. Alfalight awarded $1.7M from Army Research Lab
4. Mirus Bio awarded patent on RNA delivery
5. UW Biomedical Engineering awarded $2.9 million research grant
6. Two companies awarded state tech grants
7. Alfalight awarded $4.5 million Army Research contract
8. UW-Madison awarded $20 million grant for protein research
9. Esker awarded patent for DeliveryWare Rules Engine
10. Wisconsin technology companies awarded over $24 million in government funding
11. ConjuGon Awarded $250,000
Post Your Comments:
(Date:11/24/2015)... ... November 24, 2015 , ... InSphero AG, the leading supplier of easy-to-use solutions ... Melanie Aregger to serve as Chief Operating Officer. , Having joined InSphero ... team and was promoted to Head of InSphero Diagnostics in 2014. There ...
(Date:11/24/2015)... QC , Nov. 24, 2015 /CNW Telbec/ - ProMetic ... "Corporation") announced today that Mr. Pierre Laurin , President ... corporate presentation at the upcoming Piper Jaffray 27 th ... Palace Hotel, on December 1-2, 2015. st ... available for one-on-one meetings throughout the day. The presentation will ...
(Date:11/24/2015)... Nov. 24, 2015 HemoShear Therapeutics, LLC, ... drugs for metabolic disorders, announced today the appointment ... Board of Directors (BOD). Mr. Watkins is the ... Genome Sciences (HGS), and also served as the ... Jim Powers , Chairman and CEO of HemoShear ...
(Date:11/24/2015)... NEW YORK , November 24, 2015 /PRNewswire/ ... Bristol-Myers Squibb in a European ... Company in which the companies will work closely together ... other areas of unmet medical need. The collaboration is underpinned ... the latest LSP fund. This is the first investment by ...
Breaking Biology Technology:
(Date:10/29/2015)... , Oct. 29, 2015   MedNet Solutions , ... entire spectrum of clinical research, is pleased to announce ... Tech Association (MHTA) as one of only three finalists ... "Software – Small and Growing" category. The Tekne Awards honor ... have shown superior technology innovation and leadership. ...
(Date:10/29/2015)... Daon, a global leader in mobile biometric ... new version of its IdentityX Platform , IdentityX ... have already installed IdentityX v4.0 and are ... FIDO UAF certified server component as an option ... features. These customers include some of the largest and ...
(Date:10/29/2015)... , Oct. 29, 2015  Connected health pioneer, ... the explosion of technology-enabled health and wellness, and the ... book, The Internet of Healthy Things ... or smartphones even existed, Dr. Kvedar, vice president, Connected ... health care delivery, moving care from the hospital or ...
Breaking Biology News(10 mins):