Navigation Links
GlaxoSmithKline Announces Data on TYKERB(R) (Lapatinib) Plus Capecitabine for the Treatment of HER2 Positive Breast Cancer Brain Metastases
Date:12/17/2007

who have received prior therapy including an anthracycline, a taxane, and trastuzumab.

TYVERB has been approved in more than 15 countries, and marketing applications for TYKERB/TYVERB have been filed around the world.

Important Safety Information*

As with other therapies for HER2 overexpression, Tykerb has been associated with reports of decreases in left ventricular ejection fraction (LVEF). Caution should be taken if Tykerb is to be administered to patients with pre-existing cardiac conditions, including uncontrolled or symptomatic angina, arrhythmias, or congestive heart failure. LVEF should be evaluated in all patients prior to and during treatment with Tykerb.

A dose reduction should be considered for patients with severe hepatic impairment.

Diarrhea was the most common adverse event resulting in discontinuation of study medication. Proactive management of diarrhea with anti-diarrheal agents is important, and severe cases of diarrhea may require administration of oral or intravenous electrolytes and fluids and interruption or discontinuation of therapy with Tykerb.

Tykerb has been associated with interstitial lung disease and pneumonitis. Discontinue Tykerb if patients experience severe pulmonary symptoms.*

Tykerb prolongs the QT interval in some patients. Consider ECG and electrolyte monitoring.

Fetal harm can occur when administered to a pregnant woman. Women should be advised not to become pregnant when taking Tykerb.

The most common adverse events (>20 percent) during treatment with Tykerb plus capecitabine were diarrhea, vomiting, nausea, fatigue, palmar-plantar erythrodysethesia, and rash.

*Please see full prescribing information.

About GlaxoSmithKline

GlaxoSmithKline -- one of the world's leading research-based pharmaceutical and healthcare companies -- is committed to improving the quality of human life by enabling people to do more, feel better and live longer. For comp
'/>"/>

SOURCE GlaxoSmithKline
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related biology technology :

1. GlaxoSmithKline Recognizes University of Michigans Dr. Daniel F. Hayes as the First Recipient of the Gianni Bonadonna Breast Cancer Award
2. AUDIO from Medialink and GlaxoSmithKline: Fiber Key in Managing Irritable Bowel Syndrome (IBS) Symptoms
3. Exelixis Submits XL880 Diligence Report to GlaxoSmithKline
4. GlaxoSmithKline Awarded U.S. Department of Defense Contract to Pursue Novel Antibacterial Research Program
5. GlaxoSmithKline and Anacor Pharmaceuticals Form Alliance to Develop Systemic Antivirals and Antibiotics Based on Boron Chemistry
6. BioWa Announces Licensing of BioWas POTELLIGENT(R) Technology by GlaxoSmithkline for Use in Antibody Research and Development
7. GlaxoSmithKline Consumer Healthcare Recommends Maintaining FDAS Current Two-Class Drug System
8. GlaxoSmithKline Responds to JAMA Article on the ICES Thiazolidinediones and Cardiovascular Outcomes in Older Patients with Diabetes
9. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
10. YM BIOSCIENCES ANNOUNCES COMPLIANCE WITH AIM RULE 26
11. Emisphere Technologies, Inc. Announces Pricing of Registered Direct Offering
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/19/2014)... 2014 XenoTech announces an exclusive ... metabolite production from bioactive small molecules. Based ... technology enables convenient and timely assessment of critical ... Vice President of Commercial Operations, Christian Darabant, “the ... risk can be measured directly by comparison with ...
(Date:8/19/2014)... - iCo Therapeutics Inc. ("iCo" or "the Company") (TSX-V: ... Oral Amphotericin B (Oral Amp B) drug candidate ... ImmuneCarta®, the immune monitoring business unit of Caprion, ... Amp B in reactivating latent HIV viral reservoirs ... with antiretroviral therapy. Memory cells, ...
(Date:8/18/2014)... 2014 BioElectronics Corporation (OTC Pink: ... devices said that its EVP Dr. ... as part of its Executive Interview Series. ... at http://ceolive.tv/bioelectronics-corp-otc-biel/biel-videos/2282-ceolive-tv-interview-bioelectronics-corp-otcqb-biel In ... the unique advantages of BioElectronics patented technology ...
(Date:8/18/2014)... -- According to the new research ... Wastewater Treatment and Industrial Wastewater Treatment), By Type ... Configuration (Internal/Submerged and External/Sidestream), and By Region-Trends & ... for membrane bioreactor systems is projected to reach ... of 15.28% between 2014 and 2019. ...
Breaking Biology Technology:Beyond Metabolite Identification, Testable Quantities Now Offered by XenoTech 2Beyond Metabolite Identification, Testable Quantities Now Offered by XenoTech 3iCo Therapeutics Announces Positive Oral Amphotericin B Study Results 2iCo Therapeutics Announces Positive Oral Amphotericin B Study Results 3BioElectronics EVP Dr. Deepak Kotak Interviewed on CEO Live 2BioElectronics EVP Dr. Deepak Kotak Interviewed on CEO Live 3Membrane Bioreactor Systems Market Worth $2,927 Million by 2019 2Membrane Bioreactor Systems Market Worth $2,927 Million by 2019 3
... Milwaukee, Wis. — A water main break Thursday ... disrupt water service Friday to 37 companies in the ... parks director of development said businesses in the incubator ... Mascari, whose office is located in the 137,000-square-foot Technology ...
... Madison, Wis. A professor who has worked for ... the lifespan of rhesus monkeys was featured in the MIT ... a colony of 78 monkeys at the University of Wisconsin-Madison, ... expand the lifespans of mice. But while testing on mice ...
... Third Wave Technologies said on Tuesday that a patent ... of its intellecual property in the U.S. , ,The patent ... analysis products with a type of chain reaction that makes ... Japanese patent for its existing Invader chemistry. , ,"These important, ...
Cached Biology Technology:
(Date:8/19/2014)... caesarean section rate, suggests a new commentary published today ... Obstetrics and Gynaecology (BJOG) . , China has one ... Of 16 million babies born in 2010, approximately half ... known, the current Chinese language literature on caesarean rates ... to 58%. However, before the 1980s, the caesarean rate ...
(Date:8/19/2014)... HOUSTON, Aug. 19, 2014 To improve students, ... poor grades, the University of Houston (UH) implemented ... for students at risk for failure. , ... Coordinating Board (THECB), the Department of Biology and ... first-year students taking "General Biology" for non-majors and ...
(Date:8/19/2014)... systems be used in supermarkets to encourage healthier spending ... to answer that very question by tracking the purchasing ... Stars System to rate the nutritional value of foods ... Brand Lab,s David Just, PhD, and Brian Wansink PhD, ... records of over 150 Hannaford Supermarkets in the Northeastern ...
Breaking Biology News(10 mins):Is China's 50 percent cesarean section delivery rate too high? 2Is China's 50 percent cesarean section delivery rate too high? 3University of Houson program earns kudos for improving grades, retaining students 2University of Houson program earns kudos for improving grades, retaining students 3
... Shakespeare. In humans, nature may be less than half of ... researchers has found. In the first study of its ... explain why human birds of a feather flock together, but ... upon the social environment in which individuals interact with one ...
... Stanford University scientists have built the first solar cell made ... used in photovoltaic devices today. The results are ... ACS Nano . "Carbon has the potential to ... author Zhenan Bao, a professor of chemical engineering at Stanford. ...
... stem cells such as regenerating damaged tissues or organs ... past decade. While these types of applications are exciting, it ... immediate impact of stem cells on human health will most ... drugs. , The ability to generate stem cells by reprogramming ...
Cached Biology News:Social factors trump genetic forces in forging friendships, CU-led study finds 2Stanford scientists build the first all-carbon solar cell 2Stanford scientists build the first all-carbon solar cell 3The role of stem cells in developing new drugs 2
... (Dual-Stage Quadrupole) Thermo Scientific (Part of ... analytical instrumentation, introduces the latest product innovation ... Based on the proven reliability and performance ... systems, the DSQ II incorporates the new ...
... variant: With the macro- and ... and Skoog (1962) and the ... et al. (1968). Preparation Quantity ... grams of powder per liter ...
... Contents include: Microarray hybridization chamber ... chamber top, clamp, thumbscrew) Microarray chamber user ... and are intended to be cleaned and ... with Agilents Catalog Oligo Microarray kits and ...
Reported to support murine B lymphocytes, hematopoietic tissue from bone marrow, B cells stimulated with lipopolysaccharide, T lymphocytes, and a variety of hybrid cells....
Biology Products: