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GeoVax Labs Presents New Findings on Potential HIV Vaccine at 2012 Conference on Retroviruses and Opportunistic Infections (CROI)
Date:3/7/2012

e exposed to a primate version of the HIV virus SIVE660 to see if the vaccine was protective. An 87% per exposure vaccine efficacy was achieved against a 1st series of 12 weekly exposures to SIVE660 with 5 out of 7 vaccinated animals being protected and none of the 9 animals in the unvaccinated group being protected. The 5 uninfected animals were rested for a year, boosted once with the MVA vaccine, rested for a half year and again exposed to 12 challenges with SIVE660. For this 2nd series of exposures, an 82% per exposure vaccine efficacy was achieved with 4 out of 5 animals being protected whereas unvaccinated animals had become infected. At this point the 4 uninfected animals were rested for 6 more months and then serially exposed to the highly potent SIV251 simian version of the HIV virus. For this last challenge, an 84% per exposure vaccine efficacy was achieved with 3 out of 4 animals not acquiring infection until the 11th or 12th challenge. Protected animals did occasionally show low indications of virus, but these were transient, seen at only one bleed, and appear to have represented locally controlled infections or false positives. No other HIV vaccine candidate currently in human clinical testing has achieved this level of preclinical success in non-human primates.

"Repeated virus challenges in animals are used to mimic sexual transmission," explained Dr. Robinson. "The hope is that the results in the non-human primate models will translate into vaccine-induced prevention of infection in humans."

"Excellent results like these give the industry hope that an effective HIV vaccine with long-lasting protection is not far from reality, and bolster our confidence that we are on the right track," says GeoVax's CEO, Dr. Robert McNally.

CROI is a scientifically focused meeting of the world's leading researchers working to understand, prevent, and treat HIV/AIDS and its complications. The goal of CROI is to provide a forum for translating labora
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