Genzyme Reports Strong First-Quar...( (Anti-thymocyte Globulin [Rabbit])...)

(Anti-thymocyte Globulin [Rabbit]) and Lymphoglobuline(R) (Anti-

thymocyte Globulin [Equine]) rose 11 percent to $43.7 million from

$39.4 million. Worldwide demand for Thymoglobulin remains strong. The

product's growth over the past several quarters has been hindered by

supply constraints caused by a manufacturing issue during 2007 that

affected product appearance in some lots. Genzyme instituted a

procedure at its French manufacturing plant at the end of last year

that resolved this manufacturing issue. The company continues to

monitor Thymoglobulin lots produced last year and, if necessary, will

recall any lots that are expected to go out of specification prior to

the originally established expiry period. Genzyme expects

Thymoglobulin sales to accelerate in the second-half of this year as

supply levels increase to meet full demand for the product.

-- Within the Biosurgery business, sales of Synvisc(R) (hylan G-F 20) and

Synvisc-ONE(TM) (hylan G-F 20) rose to $56.1 million from $53.6

million, an increase of 5 percent. Synvisc-One received CE Mark

approval in the European Union in December, and Genzyme is preparing to

introduce the product into the marketplace, where it will be the only

treatment of its kind to provide six months of pain relief with a

single injection. The company has already launched the product in the

United Kingdom, Germany and Italy. Genzyme will pursue marketing

approvals for Synvisc-One in Canada, Asia and Latin America based on

the European CE mark approval, and FDA action on a marketing

application in the United States is expected later this year. By

simplifying osteoarthritis pain management and thereby reaching a

broader set of patients, Synvisc-ONE is expected to drive the

significant growth
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