Date:3/6/2008

rding the approval of Renvela(R) for use in non-dialysis chronic kidney disease patients and the timing of such discussions; the availability and extent of third-party reimbursement for Renvela(R); and the risks and uncertainties described in reports filed by Genzyme with the Securities and Exchange Commission under the Securities Exchange Act of 1934, as amended, including without limitation the information under the heading "Risk Factors" in the Management's Discussion and Analysis of Financial Condition and Results of Operations section in Genzyme's Annual Report on Form 10-K for the year ended December 31, 2007. Genzyme cautions investors not to place substantial reliance on the forward-looking statements contained in this press release. These statements speak only as of the date of this press release, and Genzyme undertakes no obligation to update or revise these statements.

Genzyme's press releases and other company information are available at http://www.genzyme.com and by calling Genzyme's investor information line at 1-800-905-4369 within the United States or 1-678-999-4572 outside the United States.

Genzyme(R), Renagel(R) and Renvela(R) are registered trademarks of Genzyme Corporation. All rights reserved.

Media Contact: Investor Contact:

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