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Genzyme Files Applications for Approval of Mozobil in the United States and Europe
Date:6/17/2008

CAMBRIDGE, Mass., June 17 /PRNewswire-FirstCall/ -- Genzyme Corporation (Nasdaq: GENZ) announced today that it has submitted marketing applications in both the United States and the European Union for Mozobil(TM) (plerixafor), a product candidate intended to enhance mobilization of hematopoietic stem cells for collection and subsequent autologous transplantation in patients with lymphoma and multiple myeloma. The company has requested priority review of its U.S. application and, if granted, Mozobil could be approved by the end of this year. European approval is expected in 2009. Additional global applications in up to 60 countries are expected to follow.

Important Clinical Role

Mozobil is designed to mobilize stem cells from the bone marrow into the bloodstream where they can be collected, making it more likely for a patient with certain types of cancers to receive a successful transplant. Specifically, patients with non-Hodgkin's and Hodgkin's lymphomas and multiple myeloma often receive high-dose chemotherapy, a process that destroys bone marrow. A stem cell transplant is required to replenish blood-forming bone marrow cells destroyed by high-dose chemotherapy. Stem cells differentiate into the mature red blood cells, white blood cells, and platelets that a healthy person needs.

Currently, before a transplant can take place, patients may receive a prescribed dose of chemotherapy and/or other drugs, called growth factors, to help mobilize their hematopoietic stem cells into the bloodstream. Once the cells are released into the bloodstream, they are easier to collect in preparation for a transplant.

In order for the transplant to take place, a minimum number of approximately 2 million cells per kilogram of body
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SOURCE Genzyme Corporation
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