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Genstruct to Present Results of Collaboration with Top Pharmaceutical Company at American Association for Cancer Research's Annual Meeting
Date:4/14/2009

DENVER and CAMBRIDGE, Mass., April 14 /PRNewswire/ -- (AACR 100th Annual Meeting 2009) - Genstruct Inc., a systems biology company focused on identifying molecular mechanisms, networks and biomarkers to better develop novel therapeutics, molecular diagnostics and patient-specific therapies, today announced that the results of a joint collaboration with one of its top pharmaceutical partners will be presented at the American Association for Cancer Research's (AACR) 100th Annual Meeting 2009 being held in Denver, Colo. April 18-22, 2009.

Michael Macoritto, Ph.D., project lead/scientist II at Genstruct will be presenting a poster titled, "Causal Reasoning Identifies Mechanisms of Sensitivity for a Novel AKT Kinase Inhibitor: GSK690693" on April 21 from 1:00 - 5:00 p.m. The poster will focus on how Genstruct and its partner evaluated the mechanisms for sensitivity for GSK690693 in six cell cultures and three xenografts from human breast, prostate and ovarian cancer cell lines using Genstruct's Causal Network(TM) modeling platform on RNA expression and phosphoproteomics data.

"This research project is an excellent example of the capabilities of our Causal Network Modeling platform," said Dr. Macoritto. "By using causal modeling, our team of expert scientists was able to demonstrate one of the main tenets of systems biology -- that the networks that regulate cellular processes are conserved across tumor and tissue types, even when the transcriptional responses of these tissues are markedly different."

About Genstruct

Founded in 2002, Genstruct is a systems biology company focused on elucidating the complexity of biology for the development of safe and effective therapeutics and molecular diagnostics. By developing Causal Network(TM) models for complex biological systems, Genstruct develops a deep molecular understanding of diseases and drug action, and designs mechanistic biomarkers and molecular diagnostics to facilitate drug development and personalized medicine. Genstruct's Consulting Services division engages in short-, mid- and long-term partnerships with top tier pharmaceutical and life sciences companies, to develop new therapeutics and mechanistic biomarkers in the areas of oncology, metabolic disorders, cardiovascular diseases and inflammation. Genstruct was awarded the Bio-IT World 2008 Best Practices Award in the Drug Discovery & Development category for its joint collaboration with Sirtris Pharmaceuticals (a GSK company). Genstruct is a privately held company based in Cambridge, Mass. For more information, please visit www.genstruct.com.

Genstruct and the Genstruct logo are registered trademarks and Causal Network Model and Knowledge Assembly are trademarks of Genstruct, Inc. All other trademarks or registered trademarks are properties of their respective owners.

    Contact:
    Karen Higgins
    A & E Communications for Genstruct
    (610) 831-5723
    khiggins@aandecomm.com


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