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Genstruct Added to The Biomarker Consortium's Rapidly Growing Roster of Industry Experts
Date:11/4/2008

CAMBRIDGE, Mass., Nov. 4 /PRNewswire/ -- Genstruct Inc., a systems biology company focused on identifying molecular mechanisms, networks and biomarkers to better develop novel therapeutics and molecular diagnostics, today announced that it has become a member of The Biomarker Consortium, a public/private research partnership managed by the Foundation for the National Institutes on Health (FNIH), and founded by the National Institutes of Health (NIH), the Food and Drug Administration (FDA) and the Pharmaceutical Research and Manufacturers of America (PhRMA).

"Being an active contributor in The Biomarker Consortium's initiatives to discover, develop and qualify biological markers to support new drug development, preventative medicine and medical diagnostics is an excellent opportunity for Genstruct to share our knowledge as well as collaborate with other industry experts to help accelerate drug discovery and development," said Dr. Keith O. Elliston, president and CEO at Genstruct. "Our technology allows one to identify mechanism-based biomarkers which can then be qualified and validated in clinical studies rather than working backwards from clinical correlations, enabling us to provide a unique viewpoint to this group based on our experience."

Biomarkers (biological markers) are molecular, biological or physical characteristics that indicate a specific, underlying physiologic state to identify risk for disease, to make a diagnosis and to guide treatment, according to The Biomarker Consortium. The group aims to rapidly identify and qualify biomarkers to support basic and translational research, guide clinical practice and, ultimately, support the development of safe and effective medicines and treatments.

Genstruct's proprietary Causal Network(TM) Modeling platform for systems biology enables scientists to break down cognitive barriers that impede critical path research. Genstruct's computable models of biology lead directly to the discovery of compound mechanisms of action (MOA) and biomarkers of safety and efficacy. Its scientists leverage the system and methodologies for internal research programs as well as research partnerships with pharmaceutical companies in order to streamline drug discovery and development and improve clinical trial design and implementation.

Dr. Elliston added, "We have initially focused on three core disease areas at Genstruct: oncology, metabolic disorders and inflammation. These are all key areas of research for The Biomarker Consortium as well. We believe that the identification of molecular mechanisms and mechanistic biomarkers in these disease areas through systems biology approaches will ultimately lead to better decisions, lower product failure rates, optimal clinical trial design and execution and faster FDA product approval."

About Genstruct

Founded in 2002, Genstruct is a systems biology company focused on elucidating the complexity of biology for the development of safe and effective therapeutics and molecular diagnostics. By developing Causal Network(TM) models for complex biological systems, Genstruct develops a deep molecular understanding of diseases and drug action, and designs mechanistic biomarkers and molecular diagnostics to facilitate drug development and personalized medicine. Genstruct's Consulting Services division engages in short-, mid- and long-term partnerships with top tier pharmaceutical and life sciences companies, to develop new therapeutics and mechanistic biomarkers in the areas of oncology, metabolic disorders, cardiovascular diseases and inflammation. Genstruct was awarded the Bio-IT World 2008 Best Practices Award in the Drug Discovery & Development category for its joint collaboration with Sirtris Pharmaceuticals (a GSK company). Genstruct is a privately held company based in Cambridge, Mass. For more information, please visit http://www.genstruct.com.

Genstruct and the Genstruct logo are registered trademarks and Causal Network Model and Knowledge Assembly are trademarks of Genstruct, Inc. All other trademarks or registered trademarks are properties of their respective owners.

Contact:

Karen Higgins

A & E Communications for Genstruct

(610) 831-5723

khiggins@aandecomm.com


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