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Genomic Health Presents Six New Studies Including Four Oral Presentations in Breast, Colon and Renal Cancers at American Society of Clinical Oncology (ASCO) Annual Meeting
Date:6/5/2010

cancer has been well-documented in community practice as well as clinical trials; however causes of the differences in incidence, mortality, and age of disease onset between women of African ancestry and women of other racial and ethnic backgrounds are not yet fully understood.  Using the Oncotype DX breast cancer Recurrence Score in an analysis of the SWOG 8814 adjuvant breast cancer clinical trial previously conducted by the Southwest Oncology Group (SWOG), researchers identified higher levels of proliferation genes in 27 African American ER-positive breast cancer patients compared to 340 other patients as a potential biologic cause of racial survival disparity observed in this study.

"This analysis suggests worse survival among African-American breast cancer patients was due in large part to tumors with higher proliferation and not to differences in degree of endocrine responsiveness," said Kathy S. Albain M.D., Professor of Medicine, Division of Hematology/Oncology, Department of Medicine, Loyola University Chicago Stritch School of Medicine, Cardinal Bernardin Cancer Center, Loyola University Health System, Maywood, Il, and first author of the study.  "These intriguing findings provide a starting point for additional research, which may impact adjuvant treatment selection for this patient population."

The study, "Potential biologic causes of the racial survival disparity in adjuvant trials of ER-positive breast cancer" (Abstract #511), examined estrogen receptor-positive patients with node positive disease and found that even after adjusting for treatment and other prognostic factors, African-American patients still had a 44 percent higher risk of death than the rest of the patient population.  Gene expression analysis with Oncotype DX found significa
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SOURCE Genomic Health, Inc.
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