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Genomic Health Presents Six New Studies Including Four Oral Presentations in Breast, Colon and Renal Cancers at American Society of Clinical Oncology (ASCO) Annual Meeting
Date:6/5/2010

the 12-gene colon cancer Recurrence Score" (Abstract #3503), will be presented in an oral discussion on Sunday, June 6.

"Some tumor characteristics, such as grade, and a small number of individual genes were identified that may distinguish stage II and III colon cancers.  However, there is a striking similarity between the two stages for the vast majority of the 375 genes studied and for the 12-gene Oncotype DX colon cancer Recurrence Score," said Michael J. O'Connell, M.D., associate chairman of the National Surgical Adjuvant Breast and Bowel Project (NSABP).  "Earlier this year physicians began incorporating Oncotype DX into clinical practice for stage II colon cancer patients.  We are now conducting additional research to evaluate this test for treatment planning in stage III disease, based on the similarities observed in this study."

Pathologic markers and expression of 375 genes were compared between 634 stage II and 844 stage III patients across four studies that were conducted to develop the Oncotype DX colon cancer test.  Results demonstrated that the vast majority of the 375 genes and the Recurrence Score appeared to be stage-independent, both in terms of the levels of gene expression and the relationships to patient outcome. However, there were differences identified between stage II and stage III colon cancer for some tumor characteristics and a small number of the individual genes which warrant further study.  The investigators concluded that the clinical relevance of these differences between stage II and III colon cancer should be further examined in prospectively designed studies.

Leveraging Access to Large Studies to Refine Understanding of Breast Cancer Biology, Recurrence

The racial disparity in breast
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SOURCE Genomic Health, Inc.
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