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Genomic Health Presents Results From First Clinical Decision Making Study of Oncotype DX® Colon Cancer at the 2012 Gastrointestinal Cancers Symposium
Date:1/20/2012

efore having Oncotype DX testing, physicians changed treatment recommendations based on the Recurrence Score results in 27 patients (29 percent).  Two-thirds (67 percent) of changes in treatment recommendations were decreases in treatment intensity (changes from chemotherapy to observation or from oxaliplatin-containing chemotherapy to treatment with fluoropyrimidine monotherapy), while one-third (33 percent) of changes were increased treatment intensity.

"In the past, selection of stage II patients for chemotherapy treatment following surgery has been based on a limited set of clinical and pathologic markers that are uninformative for most patients," said Thomas H. Cartwright, M.D., Ocala Oncology, Ocala, Florida, and the principal investigator of this study. "The Oncotype DX colon cancer test has been clinically validated as a predictor of individual recurrence risk for stage II colon cancer patients, providing quantitative information about recurrence risk which has not been available with conventional measures.   The test is now being used in treatment planning by physicians and patients worldwide, and represents an important advancement in bringing personalized medicine into today's clinical setting to benefit patients."

The new clinical decision-making data adds to the growing list of recent colon cancer milestones achieved by Genomic Health including:

  • Publication of the positive results from the landmark QUASAR clinical validation study in the Journal of Clinical Oncology, which established that the Oncotype DX colon cancer test predicts recurrence risk in stage II colon cancer patients following surgery and provides additional clinical value beyond conventional measures such as T-stage, mismatch repair (MMR) status, nodes examined, grade and lymphovascular invasion;
  • Obtained Medicare coverage policy for the Oncotype DX colon cancer test, which ensu
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SOURCE Genomic Health, Inc.
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