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Genomic Health Presents Multiple International Studies Demonstrating Worldwide Value of Oncotype DX® Breast Cancer Test
Date:3/17/2011

Prospective Clinical Study on the Impact of Oncotype DX on Adjuvant Treatment Decision and Risk Classification by Nottingham Prognostic Index (NPI) and Recurrence Score (RS)" will be presented on Thursday, March 17.

"Results from our study involving leading physicians in the United Kingdom, combined with the other research presented at the St. Gallen Conference, support the clinical utility of the Oncotype DX breast cancer test in early-stage breast cancer patients throughout multiple regions in the world," said Simon Holt, MA, MB, BChir, FRCS, Lead Breast Surgeon, Hywel Dda NHS Trust Board, Wales, UK.  "By providing further insight into the underlying tumor biology of breast cancer, the Recurrence Score gives me greater confidence in selecting the most appropriate treatment option based on that patient's individual disease."

Oncotype DX Impacts Physician Assessments in Greece and Japan

  • Greece: In a study of 42 patients, the RS result reclassified the assessment of risk and likelihood of chemotherapy benefit in more than half of patients compared to the traditional criteria.  The study reinforces that clinicopathologic or guideline criteria for categorizing patients does not predict the RS from the 21-gene Oncotype DX assay.  The study, "Impact of the 21-gene Recurrence Score Assay on Treatment Decision in Early Breast Cancer (EBC) Patients with Favorable Prognostic Factors," will be presented on Thursday, March 17.
  • Japan: Results from a study of 142 patients demonstrated that conventional pathological factors are not equivalent to the use of the RS in the treatment decision making process for early-stage breast cancer patients in Japan.  The correlation of the RS with a variety of individual markers was poor to moderate.  The researchers suggest that tumor genomic expression provides unique information for prognostic
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SOURCE Genomic Health, Inc.
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