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Genomic Health Presents Multiple International Studies Demonstrating Worldwide Value of Oncotype DX® Breast Cancer Test
Date:3/17/2011

reduction in the use of chemotherapy after Oncotype DX testing.  The study, "German Multicentre Decision Impact Study of Oncotype DX Recurrence Score on Adjuvant Treatment in Estrogen Receptor Positive Node Negative and Node Positive Early Breast Cancer," will be presented on Thursday, March 17.
  • Spain: Results from a prospective multicenter study of 107 early-stage Spanish breast cancer patients demonstrated that the use of the Oncotype DX test changed the adjuvant treatment recommendation in approximately 32 percent of patients and that physician confidence in the treatment recommendations increased in 60 percent of cases.  The results also provided evidence on how Oncotype DX and traditional pathological factors are complementary in supporting change in treatment recommendations.  The study, "Prospective trans-GEICAM Study of the Impact of the 21-Gene Recurrence Score Assay and Traditional Clinico-Pathological Factors on Clinical Decision Making in Women with Estrogen Receptor-positive, HER2-negative, Node-negative Breast Cancer," will be presented on Thursday, March 17.
  • United Kingdom: Results based on an analysis of Oncotype DX in 107 early-stage breast cancer patients in the UK demonstrate a reduction in the use of adjuvant chemotherapy in 14 percent of patients and a change in treatment recommendations in 33 percent of cases.  Additionally, researchers found that the RS can provide UK physicians and patients with additional prognostic information beyond that currently provided by the Nottingham Prognostic Index (NPI), the current decision aid frequently used to make adjuvant breast cancer treatment decisions in the region. The researchers concluded that the results suggest that it is applicable and feasible to perform in the UK setting with a reduction in the use of adjuvant chemotherapy consistent with the findings of other reported studies. The study, "Results from a
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