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Genomic Health Presents Multiple International Studies Demonstrating Worldwide Value of Oncotype DX® Breast Cancer Test
Date:3/17/2011

y adopted for guiding treatment decisions in early-stage breast cancer and incorporated in published guidelines of leading cancer organizations.  Oncotype DX is available for use worldwide and, as of December 31, 2010, more than 10,000 physicians in more than 60 countries had ordered more than 190,000 Oncotype DX tests.

"Oncotype DX provides a fundamental change in our therapy policy, representing a step towards more personalized medicine in Europe," said Wolfgang Eiermann, Professor of Gynecology and Medical Director, Red Cross Women's Hospital Munich.  "Based on these data, there is a clear need for Oncotype DX to be included in daily clinical practice."

Oncotype DX Changes Physician Treatment Recommendations in Germany, Spain and the UK

  • Multiple Countries: In a meta-analysis of nine published decision impact studies with a total of 1,154 early-stage breast cancer patients, the RS result led to an approximately 35 percent change in treatment decisions.  The overall reduction of chemotherapy recommendations or use was approximately 24 percent.  The study, "Meta-analysis of the Decision Impact of the 21-Gene Breast Cancer Recurrence Score in Clinical Practice," will be presented on Thursday, March 17.
  • Germany: Results from 149 early-stage breast cancer patients with node negative disease and 48 patients with node positive disease in Germany showed that the use of the RS result can have an impact on adjuvant treatment decision making.  Specifically, based on the RS result, the adjuvant treatment recommendation changed in 38 percent of node negative cases and in 48 percent of node positive cases.  Knowledge of the RS result led to a change from chemotherapy plus hormonal therapy to hormonal therapy alone more commonly than from hormonal therapy alone to the addition of chemotherapy.  Overall, there was a 17 percent
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SOURCE Genomic Health, Inc.
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