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Genomic Health Announces Results from Biomarker Discovery Program Utilizing Next-Generation Sequencing to Compare Normal and Tumor Breast Tissue
Date:2/3/2011

essed between tumor and normal specimens.  The association of each of these with the risk of breast cancer recurrence was sought by consulting published gene expression results from approximately 3,000 patients with breast cancer tumors for which there was a record of clinical outcome.  This analysis showed that sets of transcripts over-expressed in tumors compared with normal tissues produced only a modest enrichment for prognostic significance, but further evaluation of these transcripts by gene set analysis produced a set that is highly enriched for prognostic genes.

In addition, an algorithm was developed to detect and quantify transcripts from non-coding regions of the genome and through this process more than 1,000 differentially expressed non-coding sequences were identified.  Reverse transcriptase-polymerase chain reaction (RT-PCR) assays were designed for a number of the non-coding transcripts and were used to screen a 136 patient cohort of breast cancer specimens.  Several of these non-coding RNAs proved to be associated with breast cancer recurrence risk.  

About Genomic Health

Genomic Health, Inc. (NASDAQ: GHDX) is a molecular diagnostics company focused on the global development and commercialization of genomic-based clinical laboratory services that analyze the underlying biology of cancer allowing physicians and patients to make individualized treatment decisions. Its lead product, the Oncotype DX® Breast Cancer test, has been shown to predict the likelihood of chemotherapy benefit as well as recurrence in early-stage ER+ breast cancer. In addition to this widely adopted test, Genomic Health provides the Oncotype DX Colon Cancer test, the first multigene expression test developed for the assessment of risk of recurrence in patients with stage II disease. As of September 30, 2010, more than 10,000 ph
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SOURCE Genomic Health, Inc.
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