Navigation Links
Genomic Health Announces Results from Biomarker Discovery Program Utilizing Next-Generation Sequencing to Compare Normal and Tumor Breast Tissue
Date:2/3/2011

essed between tumor and normal specimens.  The association of each of these with the risk of breast cancer recurrence was sought by consulting published gene expression results from approximately 3,000 patients with breast cancer tumors for which there was a record of clinical outcome.  This analysis showed that sets of transcripts over-expressed in tumors compared with normal tissues produced only a modest enrichment for prognostic significance, but further evaluation of these transcripts by gene set analysis produced a set that is highly enriched for prognostic genes.

In addition, an algorithm was developed to detect and quantify transcripts from non-coding regions of the genome and through this process more than 1,000 differentially expressed non-coding sequences were identified.  Reverse transcriptase-polymerase chain reaction (RT-PCR) assays were designed for a number of the non-coding transcripts and were used to screen a 136 patient cohort of breast cancer specimens.  Several of these non-coding RNAs proved to be associated with breast cancer recurrence risk.  

About Genomic Health

Genomic Health, Inc. (NASDAQ: GHDX) is a molecular diagnostics company focused on the global development and commercialization of genomic-based clinical laboratory services that analyze the underlying biology of cancer allowing physicians and patients to make individualized treatment decisions. Its lead product, the Oncotype DX® Breast Cancer test, has been shown to predict the likelihood of chemotherapy benefit as well as recurrence in early-stage ER+ breast cancer. In addition to this widely adopted test, Genomic Health provides the Oncotype DX Colon Cancer test, the first multigene expression test developed for the assessment of risk of recurrence in patients with stage II disease. As of September 30, 2010, more than 10,000 ph
'/>"/>

SOURCE Genomic Health, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related biology technology :

1. Rosetta Genomics Announces Conference Call and Webcast of Second Quarter Financial Results
2. DOE JGI Director Eddy Rubin highlights the genomics of plant-based biofuels in the journal Nature
3. Rosetta Genomics Reports Second Quarter 2008 Financial Results
4. Rosetta Genomics and the National Institute of Health (NIH) to Identify Potential MicroRNA Drug Targets for HIV
5. eGenomics Awarded First U.S. Patent Covering Rapid DNA Sequencing Technology Platform to Control Hospital-Acquired Infections
6. Brewing better beer: Scientists determine the genomic origins of lager yeasts
7. Transgenomic Announces Partnership With Key Genomics for Ovarian Cancer Assay to Guide Therapeutic Options
8. As personalized, genomic medicine takes off, four developing countries show the way for others
9. U.S. Genomics Inc. Receives $4.5 Million Investment from BD
10. Helix BioPharma to Present L-DOS47 Research Findings at the National Research Council of Canadas Eighth Annual General Meeting of the Genomics and Health Initiative in Saskatoon, Canada
11. TIBCO Spotfire and INTEGROMICS Announce Genomics Data Analysis Solution to Radically Speed Drug Research and Development
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/26/2014)... SoundConnect , an award winning ... announce that Darren Suders has joined the team as ... drive the partner program through innovative offerings, ... , Darren brings more than 10-years of channel telecommunication ... channel operations, from policy development, to partner education and ...
(Date:11/26/2014)... /PRNewswrie/ -- Theravalues Corporation annuncia con orgoglio il lancio ... di Hi Europe 2014 (dal 2 al 4 dicembre, ... della curcumina con la maggiore biodisponibilità di sempre, con ... approvati dalle norme europee. La curcumina è ... ( Curcuma longa ) che è stata associata con ...
(Date:11/24/2014)... , Belgium , Nov. 24, 2014 ... sciences company focused on developing diagnostic tests for cancer and ... cancer study will be presented at the Science for Business ... Belgium . The data come from VolitionRx,s ... at the Pneumology department of the Centre Hospitalier Universitaire (CHU) ...
(Date:11/24/2014)... (PRWEB) November 24, 2014 2014 ... Dihydrazide Industry is a professional and in-depth research ... Adipic Dihydrazide information, like its definition, classification, application, ... overview. This report covers the international market analysis, ... (such as the US, Europe, Asia, China, Japan ...
Breaking Biology Technology:SoundConnect Appoints Director of Channel Development & Sales 2La curcumina con la maggiore biodisponibilità di sempre farà il suo debutto in Europa 2La curcumina con la maggiore biodisponibilità di sempre farà il suo debutto in Europa 3VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 2VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 3VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 4VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 5VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 6Adipic Dihydrazide Industry 2019 Research Forecasts on Worldwide, China Regions Now Available at ReportsnReports.com 2Adipic Dihydrazide Industry 2019 Research Forecasts on Worldwide, China Regions Now Available at ReportsnReports.com 3
... AV300 Hand-Held Vein Illumination Device to Membership , , ... LLC today announced a three year agreement with Amerinet Inc. ... vein illumination device to its members. The AccuVein AV300 ... vein position to help the healthcare professional locate veins for ...
... Pharmaceuticals, Inc. (NASDAQ: ANPI , TSX: ANP) ... (FDA) has granted 510(k) clearance for the Option(TM) Inferior ... use in both permanent and retrievable indications. Angiotech holds ... IVC Filter, which it obtained in a license agreement ...
... STOCKHOLM, June 8 Diamyd Medical reported today,that the ... (FDA) to include children with type 1 diabetes from 10 ... diabetes vaccine Diamyd(R). , (Logo: ... is conducting two parallel phase III studies, one in,Europe and ...
Cached Biology Technology:AccuVein Inks National Three-Year Group Purchasing Deal With Amerinet 2Angiotech Pharmaceuticals announces FDA 510(k) clearance of the Option(TM) Inferior Vena Cava Filter 2Angiotech Pharmaceuticals announces FDA 510(k) clearance of the Option(TM) Inferior Vena Cava Filter 3Angiotech Pharmaceuticals announces FDA 510(k) clearance of the Option(TM) Inferior Vena Cava Filter 4Angiotech Pharmaceuticals announces FDA 510(k) clearance of the Option(TM) Inferior Vena Cava Filter 5Angiotech Pharmaceuticals announces FDA 510(k) clearance of the Option(TM) Inferior Vena Cava Filter 6Diamyd(R) Phase III Study Approved for Younger Patients in the US 2
(Date:11/11/2014)... 2014  Forensicon, Inc., a Chicago ... announce the promotion of Yaniv Schiff from ... In Schiff,s new role as Director, he will lead ... forensics examiners and provide leadership within the company,s digital ... http://photos.prnewswire.com/prnh/20141110/157719 Schiff joined Forensicon in ...
(Date:11/7/2014)... conjunction with the Glendale and ... the Verdugos has announced the " GLENDALE - ... to keep the Verdugo Regional Crime Lab operational after its ... existence, the Lab has processed more than 400 DNA samples, ... "Because our number one priority is the wellbeing of ...
(Date:11/6/2014)... metastasis, yet progress in preventing and treating migratory ... particularly challenging to design drugs that work against ... biology at Harvard Medical School. , "Unfortunately, ... metastasized." , Gujral and colleagues have now identified ... understand how metastasis begins. Their findings may also ...
Breaking Biology News(10 mins):Yaniv Schiff Promoted to Director of Digital Forensics at Forensicon, Inc. 2Community Foundation Of The Verdugos Unveils Campaign To Fund Glendale-Burbank DNA Justice Project 2Migration negation 2Migration negation 3
... is associated with significantly elevated rates of functional somatic ... chemical sensitivities among women, according to new findings by ... in this month,s issue of the Journal of ... they had been physically abused as children have twice ...
... in serious decline and these include honeybees, wild bees ... in Europe is worth about 22 billion each year ... and other insects. If we don,t take action to ... negative economic consequences with worrying implications for food security. ...
... ornithologists for a long time, mainly because of their predatory ... prey. In the book, the most important information on shrikes ... in the ornithological literature and obtained by the author himself. ... integral system of adaptation, are evolutionary trends affecting changes in ...
Cached Biology News:
... kit allows for quick and reproducible immunoprecipitation (IP) ... system is more reproducible than regular IPs, which ... A/G agarose without disrupting the agarose bed. The ... Release is reversible, and elution of the immune ...
... locking design in ice/water bath This ... number, created to easily match Cornings ... yet, please order under the old ... service for assistance. ID clarifier: rack ...
Kit containing MACS equipment and reagents for immunopurification of proteins....
... software offers an intuitive, easy-to-use ... control, diverse data handling, and ... Comprehensive functions include data acquisition, ... management in both standalone and ...
Biology Products: