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Genomic Health Announces Publication of a Study Demonstrating the Oncotype DX(R) Breast Cancer Assay Influences Chemotherapy Treatment Recommendation in 44 Percent of Patients Evaluated
Date:11/10/2008

on the 2007 NCCN guidelines received a recommendation for hormone therapy alone based on their Oncotype DX Recurrence Score of less than 18. Conversely, and notably, four patients who would have received a recommendation against chemotherapy based on the 2007 NCCN guidelines were placed in the high-risk group based on their Recurrence Score of greater than 31 and received a recommendation for chemotherapy.

"As more physicians incorporate Oncotype DX into clinical practice, we gain important insight into its impact on the treatment decision process for physicians and patients," said Steven Shak, M.D., chief medical officer of Genomic Health. "There are now seven studies, conducted by independent physicians who use the test in clinical practice, demonstrating that Oncotype DX optimizes the use of chemotherapy to ensure those women who need chemotherapy get it, while sparing those who are not likely to benefit from its side effects and high costs."

About Oncotype DX(R)

Oncotype DX is the first and only multi-gene expression test commercially available that has clinical evidence validating its ability to predict the likelihood of chemotherapy benefit as well as recurrence in early-stage breast cancer. Additionally, the test report provides quantitative scores for certain individual genes. Oncotype DX has been extensively evaluated in eleven clinical studies involving nearly 4,000 breast cancer patients, including a large validation study published in The New England Journal of Medicine and a chemotherapy benefit study published in the Journal of Clinical Oncology. To date, 7,500 physicians have ordered more than 75,000 tests, and both Medicare and private health plans covering approximately 90 percent of U.S. insured lives provide reimbursement for Oncotype DX through contracts, agreements and policy decisions. Both the American Society of Clinical Oncology (ASCO) and the National Comprehensive Cancer Network recommend the use of Oncotype DX for pa
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SOURCE Genomic Health, Inc.
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