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Genomic Health Announces Multiple Colon Cancer Studies at the American Society of Clinical Oncology Gastrointestinal Cancers Symposium
Date:1/21/2011

currences and may respond less well to fluorouracil-based chemotherapy.  It is recommended that immunohistochemical (IHC) determination of MMR status be considered to identify patients for whom adjuvant chemotherapy is not indicated, but little was known regarding the variability of such assay results.  Results from this comparative study demonstrate that determination of MMR status by IHC in two different laboratories is associated with excellent inter-assay agreement.  The study, "Assay result variability during determination of mismatch repair deficiency status using immunohistochemistry: A transatlantic comparative study" (G. Hutchins et al, Abstract #403), will be presented in a poster on Saturday, January 22.

High Tumor Grade Not Found to Be a Marker of High Recurrence Risk in Stage II Colon Cancer

High tumor grade is often considered a marker of higher recurrence risk in stage II colon cancer.  However, multiple large recently reported studies have found that high tumor grade, at least in stage II colon cancer, was not associated with higher recurrence risk.  In addition, multiple different systems for tumor grading are used in clinical practice.  Results from this study confirmed that high tumor grade, as assessed by two pathologists with expertise in colon cancer, does not predict higher recurrence risk in stage II colon cancer patients and that inter-pathologist agreement on colon tumor grade is modest to moderate, even with central expert review.  The investigators concluded that the standardized colon cancer Recurrence Score assay, MMR, and T-stage should be used in the assessment of stage II patients.  The study, "Reproducibility of colon tumor grade and relationship to recurrence in the context of clinical, pathologic, and genomic tumor features in 504 patients with stage II colon cancer treated with surgery alone at the Cleveland Clinic" (I. C. Lavery et al, Abstract #526), will be presented
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