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Genomatica Produces Pure BDO From Natural Sugars
Date:6/2/2009

With downstream processing techniques proven cost-effective, Genomatica looks to develop demonstration plant

SAN DIEGO, June 2 /PRNewswire/ -- Genomatica, a sustainable chemicals company, announced today that the company's engineering team has achieved an important milestone toward the production of commercial grade 1,4-butanediol (BDO) from renewable feedstocks using Genomatica's novel bioprocess. The company has demonstrated that it can process BDO produced from sugar to greater than 99 percent purity using a proprietary and cost-effective recovery process. The achievement clears the way for development of a demonstration facility to begin operating next year.

The new process begins with producing BDO in fermentation broths generated by microbes engineered to directly produce BDO from sugars, and uses process designs and equipment compatible with large-scale chemical production. The purification achievement proves the feasibility of critical downstream process engineering elements of Genomatica's manufacturing method for renewable BDO. Fully integrated, the process will offer Genomatica's partners a competitive advantage relative to producers that today generate BDO entirely from fossil fuels.

"The first 100-percent renewably sourced and purified BDO - it's a powerful sight that symbolizes the transformation that is possible for our industry," said Christophe Schilling, chief executive officer of Genomatica. "With a cost advantage over traditional manufacturing processes, our bio-manufacturing method for BDO will release chemical producers from the fluctuations of the hydrocarbon markets and lower their overall carbon footprint, while meeting the growing demand for sustainably manufactured products."

When Genomatica began development of this breakthrough bio-manufacturing process, the company set three key laboratory-scale development milestones to commercialize the process: first, to
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