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Gained rights to HuMax-CD4 and HuMax-TAC from Merck Serono and HuMax-IL8
through asset exchange with Medarex
Commenced seven new studies:
HuMax-EGFr - Phase III front line head and neck cancer study by DAHANCA
and Phase II non small cell lung cancer study
HuMax-CD20 - Phase II front line CHOP combination study in follicular
non-Hodgkin's lymphoma, 2 RA Phase III studies, Phase II relapsed
diffuse large B-cell lymphoma study
HuMax-CD38 Phase I/II multiple myeloma study
Achieved positive clinical trial results:
HuMax-CD20 Phase II RA data
Final HuMax-CD4 Phase II cutaneous T-cell lymphoma (CTCL) data
R1507 Phase I sarcoma data
Presented pre-clinical data:
Positive data for HuMax-HepC, HuMax-EGFr and HuMax-CD20
Unique mechanisms of action of HuMax-CD4 and HuMax-EGFr
Financial Highlights:
Cash position increased for fourth consecutive year
Achieved membership in OMXC20 index on the OMX Nordic Exchange
Copenhagen
2008 Guidance
We expect to significantly expand development in 2008 in our clinical and pre-clinical programs, including plans to initiate 17 new clinical studies, filing our first biologics license application and selecting two new clinical candidates. We will pay development costs for the new and ongoing pivotal studies in HuMax-CD4 and HuMax-EGFr. Under our collaboration with GSK, we will fund half the development costs for the trials with HuMax-CD20. We expect to continue our increasing level of discovery and pre-clinical work in 2008, developing antibody products for a variety of new and existing disease targets. Finally, the 2008 projections include operating costs from the newly acquired antibody manufacturing facility.
Due to these expanded activities, Genmab's operating costs are expected
to be higher in 2008 than in 2007. In combination with increasing re
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