Navigation Links
Genetic manipulation might model cystic fibrosis

Cystic fibrosis (CF) is caused by mutations in the gene responsible for making the protein CFTR. Progress toward understanding the disease-causing mechanisms and developing new therapies has been hampered by the lack of a good animal model; e.g., CF mice fail to develop many of the symptoms seen in patients with CF. However, two independent reports in the April issue of the Journal of Clinical Investigation have described the first steps toward developing large animal (pig and ferret) models of the disease.

A team of researchers from the University of Iowa, Iowa City, and the University of Missouri Columbia, used recombinant adeno-associated virus (rAAV) vectors to alter the CFTR gene in pig fibroblasts such that was disrupted or contained the most common CF-associated mutation (delta-F508). The nucleus of these cells was used to fertilize the eggs of female pigs, and male piglets carrying one or other the mutated CFTR genes were generated. A similar approach rAAV targeting of the CFTR gene in ferret fibroblasts, followed by the transfer of the nucleus of the cells to the eggs of female ferrets was taken by John Engelhardt and colleagues, at the University of Iowa, Iowa City, to generate male ferrets carrying a mutated CFTR gene. As noted by the authors of both papers, these studies have not only provided animals that might lead to the development of a good animal model of CF, but also have described approaches that might be useful for the development of large animals models of other human genetic diseases.


Contact: Karen Honey
Journal of Clinical Investigation

Page: 1

Related biology technology :

1. NIOXIN(R) Delivers the Future to Scalp and Hair Care, Introduces the First Genetic Test to Determine the Likelihood of Hair Loss
2. AssureRx Closes Round of Funding to Commercialize Pharmacogenetic Test
3. deCODE genetics Announces Webcast of Conference Call to Discuss Full-year 2007 Financial Results
4. Genetic Engineering & Biotechnology News reports on advances in miRNA
5. Interleukin Genetics Enters into New Clinical Research Collaboration with Alticor
6. Honey bee invaders exploit the genetic resources of their predecessors
7. Genetic pathway critical to disease, aging found
8. CellCyte Genetics Corp. Continues to Move Its Technology Forward in Light of Plaintiff Law Firm Press Releases
9. deCODE genetics to Webcast Presentation at BIO CEO and Investor Conference
10. Smart Genetics Announces Plans to Launch a New Alzheimers Risk Assessment Service
11. Finkelstein Thompson LLP Announces Filing of Securities Fraud Class Action Against CellCyte Genetics Corporation
Post Your Comments:
(Date:10/10/2017)... ... October 10, 2017 , ... ... targeted antibody-drug conjugate (ADC) therapeutics, today confirmed licensing rights that give it ... Nanoparticle), a technology developed in collaboration with Children’s Hospital Los Angeles (CHLA). ...
(Date:10/10/2017)... ... October 10, 2017 , ... ... process optimization firm for the life sciences and healthcare industries, announces a presentation ... San Francisco. , The presentation, “Automating GxP Validation for Agile Cloud Platforms,” will ...
(Date:10/9/2017)... ... October 09, 2017 , ... The Giving Tree Wellness Center ... the needs of consumers who are incorporating medical marijuana into their wellness and ... , As operators of two successful Valley dispensaries, The Giving Tree’s two founders, ...
(Date:10/6/2017)... ... October 06, 2017 , ... The HealthTech Venture ... sector at their fourth annual Conference where founders, investors, innovative practitioners and collaborators ... ELEVATE pitch competition showcasing early stage digital health and med tech companies. , ...
Breaking Biology Technology:
(Date:8/23/2017)...  The general public,s help is being enlisted in what,s thought to ... and on the human body –and are believed to affect health.  ... The Microbiome Immunity Project is the largest ... the gut. The project's goal is to help advance scientific knowledge of ... ...
(Date:6/23/2017)... N.Y. , June 23, 2017  IBM (NYSE: ... dairy research, today announced a new collaboration using next-generation ... chances that the global milk supply is impacted by ... Cornell University has become the newest academic institution to ... a food safety initiative that includes IBM Research, Mars, ...
(Date:5/16/2017)... , May 16, 2017   Bridge Patient ... organizations, and MD EMR Systems , an ... partner for GE, have established a partnership to ... product and the GE Centricity™ products, including Centricity ... These new integrations will allow ...
Breaking Biology News(10 mins):