Navigation Links
Genetic manipulation might model cystic fibrosis
Date:3/6/2008

Cystic fibrosis (CF) is caused by mutations in the gene responsible for making the protein CFTR. Progress toward understanding the disease-causing mechanisms and developing new therapies has been hampered by the lack of a good animal model; e.g., CF mice fail to develop many of the symptoms seen in patients with CF. However, two independent reports in the April issue of the Journal of Clinical Investigation have described the first steps toward developing large animal (pig and ferret) models of the disease.

A team of researchers from the University of Iowa, Iowa City, and the University of Missouri Columbia, used recombinant adeno-associated virus (rAAV) vectors to alter the CFTR gene in pig fibroblasts such that was disrupted or contained the most common CF-associated mutation (delta-F508). The nucleus of these cells was used to fertilize the eggs of female pigs, and male piglets carrying one or other the mutated CFTR genes were generated. A similar approach rAAV targeting of the CFTR gene in ferret fibroblasts, followed by the transfer of the nucleus of the cells to the eggs of female ferrets was taken by John Engelhardt and colleagues, at the University of Iowa, Iowa City, to generate male ferrets carrying a mutated CFTR gene. As noted by the authors of both papers, these studies have not only provided animals that might lead to the development of a good animal model of CF, but also have described approaches that might be useful for the development of large animals models of other human genetic diseases.


'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

Page: 1

Related biology technology :

1. NIOXIN(R) Delivers the Future to Scalp and Hair Care, Introduces the First Genetic Test to Determine the Likelihood of Hair Loss
2. AssureRx Closes Round of Funding to Commercialize Pharmacogenetic Test
3. deCODE genetics Announces Webcast of Conference Call to Discuss Full-year 2007 Financial Results
4. Genetic Engineering & Biotechnology News reports on advances in miRNA
5. Interleukin Genetics Enters into New Clinical Research Collaboration with Alticor
6. Honey bee invaders exploit the genetic resources of their predecessors
7. Genetic pathway critical to disease, aging found
8. CellCyte Genetics Corp. Continues to Move Its Technology Forward in Light of Plaintiff Law Firm Press Releases
9. deCODE genetics to Webcast Presentation at BIO CEO and Investor Conference
10. Smart Genetics Announces Plans to Launch a New Alzheimers Risk Assessment Service
11. Finkelstein Thompson LLP Announces Filing of Securities Fraud Class Action Against CellCyte Genetics Corporation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/12/2017)... The report "Direct-Fed Microbials Market by Type (Lactic Acid Bacteria and Bacillus), Livestock (Pork/Swine, Poultry, ... to 2022", published by MarketsandMarkets, the global market is estimated to be valued ... by 2022, at a CAGR of 6.96% from 2016. ... ... ...
(Date:1/11/2017)... ... January 11, 2017 , ... Photonics industry and ... , are commending the U.S. Congress and President Obama for their recognition of ... of the American Innovation and Competitiveness Act (AICA). , The language of the ...
(Date:1/11/2017)... Conn. (PRWEB) , ... January 11, 2017 , ... ... sciences company developing an innovative cellular response analysis platform to measure the proteomic ... competitive Phase I Small Business Innovation Research (SBIR) grant from the National Institute ...
(Date:1/11/2017)... and BENGALURU, India , Jan. ... Biocon Ltd. (BSE code: 532523, NSE: BIOCON) today announced ... accepted Mylan,s biologics license application (BLA) for MYL-1401O, a ... This product is a proposed biosimilar to branded trastuzumab, ... The anticipated FDA goal date set under the Biosimilar ...
Breaking Biology Technology:
(Date:1/6/2017)... Colo. , Jan. 5, 2017  SomaLogic ... the "Digital Life Alliance" established by iCarbonX, the ... 2015 to build a "Global Digital Health Ecosystem ... on a combination of individual,s biological, behavioral and ... the agreement between the companies, SomaLogic will provide ...
(Date:12/22/2016)... VIEW, Calif. , Dec. 20, 2016  As part ... levels, 23andMe, the leading personal genetics company, recently released its ... Me . The book focuses on the topics of ... Next Generation Science Standards (NGSS) taught in elementary school classrooms ... second in a series by illustrator Ariana Killoran , ...
(Date:12/16/2016)... , Dec. 16, 2016   IdentyTechSolutions ... Identity management products and solutions and a cutting-edge ... today that it is offering seamless, integrated solutions ... security entrance products. The solutions provide IdentyTech,s customers ... secure their facilities from crime and theft. ...
Breaking Biology News(10 mins):