Navigation Links
Genetic discovery could lead to advances in dental treatment
Date:2/23/2009

CORVALLIS, Ore. Researchers have identified the gene that ultimately controls the production of tooth enamel, a significant advance that could some day lead to the repair of damaged enamel, a new concept in cavity prevention, and restoration or even the production of replacement teeth.

The gene, called Ctip2, is a "transcription factor" that was already known to have several functions - in immune response, and the development of skin and the nervous system. Scientists can now add tooth development to that list.

The findings were just published in the Proceedings of the National Academy of Sciences.

"It's not unusual for a gene to have multiple functions, but before this we didn't know what regulated the production of tooth enamel," said Chrissa Kioussi, an assistant professor in the College of Pharmacy at Oregon State University. "This is the first transcription factor ever found to control the formation and maturation of ameloblasts, which are the cells that secrete enamel."

The researchers used a laboratory mouse model in this study in which this gene has been "knocked out" and its protein is missing. Such mice lack basic biological systems and cannot live after birth, but allow scientists to study what is there, and what's missing.

In this case, the mice had rudimentary teeth ready to erupt, but they lacked a proper enamel coating, and never would have been functional.

"Enamel is one of the hardest coatings found in nature, it evolved to give carnivores the tough and long-lasting teeth they needed to survive," Kioussi said.

With an understanding of its genetic underpinning, Kioussi said, it may be possible to use tooth stem cells to stimulate the growth of new enamel. Some groups are already having success growing the inner portions of teeth in laboratory animal experiments, but those teeth have no hard coatings the scientists lacked the genetic material that makes enamel.

"A lot of work would still be needed to bring this to human applications, but it should work," Kioussi said. "It could be really cool, a whole new approach to dental health."

Many people have problems with eroded tooth enamel, including people who smoke, drink and especially some who use illegal drugs such as methamphetamine. And most cavities start as a hole in tooth enamel that allows decay to begin.


'/>"/>

Contact: Chrissa Kioussi
kioussic@onid.oregonstate.edu
541-737-2179
Oregon State University
Source:Eurekalert

Related biology technology :

1. Genetic information personalizes warfarin prescribing
2. Famed IT Investor and Director of 23andme Esther Dyson Identifies on IdeasProject.com Genetic Information as an Extremely Disruptive Force
3. Mouse study reveals genetic component of empathy
4. deCODE Discovers First Genetic Variant Conferring Increased Risk of Essential Tremor
5. Scientists publish complete genetic blueprint of key biofuels crop
6. Lafayette General Medical Center is the First Hospital in Louisiana to Use Genetic-Based Technology to Test for Respiratory Disease
7. Interleukin Genetics Receives Notification of Failure to Meet Continued Listing Standard Section 1003(a)(iii)
8. Epeius Biotech Awarded Patents in Europe for Targeted Genetic Anti-Cancer Medicine: Company Expands Impressive Intellectual Property Estate
9. deCODE Discovers Common Genetic Variations Contributing to Low Bone Mineral Density and Risk of Osteoporosis
10. Matching Genetics, Technology and Management Practices Critical to Meeting Strong Demand for Agricultural Crops
11. Axial Biotech Launches Genetic Test for Adolescent Idiopathic Scoliosis (AIS)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/19/2016)... - I dati saranno presentati nel ... ° Congresso della Società Americana di ... Le conclusioni dello studio indicano un tasso di risposta del ... 90% presenta una d urata della risposta (Duration Of ... cento dei pazienti ha riscontrato un beneficio clinico.   ...
(Date:5/18/2016)... 2016 The Biotech industry continues to ... that there are no opportunities ahead. Today, ActiveWallSt.com has on ... THLD ), Seattle Genetics Inc. (NASDAQ: SGEN ... Corp. (NASDAQ: OPHT ). Sign up now to ... http://www.activewallst.com/ Threshold Pharmaceuticals Inc.,s shares gained ...
(Date:5/18/2016)... ... 2016 , ... The Academy of Model Aeronautics has been helping graduating seniors ... total of $1 million in awarded scholarships. , The AMA is happy to announce ... the nation has helped bring the total of AMA scholarships that have been given ...
(Date:5/17/2016)... ... May 17, 2016 , ... ... waste reduction applications, announced today it will be showcasing ManureMagicâ„¢ at booth V1061 ... was featured in the Wall Street Journal last year and more recently made ...
Breaking Biology Technology:
(Date:4/28/2016)... and BANGALORE, India , April 28, ... Systems, a product subsidiary of Infosys (NYSE: INFY ... announced a global partnership that will provide end ... use mobile banking and payment services.      (Logo: ... key innovation area for financial services, but it also plays ...
(Date:4/15/2016)... , April 15, 2016  A new ... make more accurate underwriting decisions in a fraction ... timely, competitively priced and high-value life insurance policies ... screenings. With Force Diagnostics, rapid testing ... lifestyle data readings (blood pressure, weight, pulse, BMI, ...
(Date:3/31/2016)... March 31, 2016  Genomics firm Nabsys has completed ... Barrett Bready , M.D., who returned to the ... original technical leadership team, including Chief Technology Officer, ... Development, Steve Nurnberg and Vice President of Software and ... company. Dr. Bready served as CEO of ...
Breaking Biology News(10 mins):