"Identification of children with low-hypodiploid ALL and inherited TP53 mutations could help expand the use of life-saving cancer screening," said Linda Holmfeldt, Ph.D., a St. Jude postdoctoral fellow. She and Lei Wei, Ph.D., of the St. Jude Department of Computational Biology and formerly of Pathology, are the study's co-first authors. "Screening helps save lives by finding cancers much earlier when the odds of a cure are greatest," Holmfeldt said.
Investigators also reported deletions involving Ikaros gene family members that are rare in other ALL patients. The genes play a role in normal immune system development. The IKZF3 gene, also known as AIOLOS, was deleted in 13 percent of near haploid ALL patients. IKZF3 was deleted in nearly 53 percent of patients with low hypodiploid ALL.
Despite such differences, when researchers tested a variety of compounds against cells from both subtypes growing in the laboratory, they found compounds that targeted the PI3K pathway inhibited proliferation. Researchers are testing the effectiveness of these drugs in mouse models.
The authors are Ernesto Diaz-Flores and Mignon Loh , both of University of California School of Medicine, San Francisco; Michael Walsh , Jinghui Zhang , Debbie Payne-Turner , Michelle Churchman , Shann-Ching Chen , Kelly McCastlain , Jared Becksfort '/>"/>
SOURCE St. Jude Children's Research Hospital
Copyright©2012 PR Newswire.
All rights reserved
Related biology technology :
1. Game changing diagnostic & prognostic prostate cancer genetic tests revealed by Jefferson
2. The Leading Edge Of Medical Innovation: New Prenatal Genetic Tests Use Moms Blood To Learn About Her Baby
3. GeneTex Launches New Antibody Against Phosphorylated Histone H3 for Epigenetics Research
4. Can a genetic variation in the vitamin D receptor protect against osteoporosis?
5. The American College of Obstetricians and Gynecologists Committee on Genetics and the Society for Maternal-Fetal Medicine Publications Committee Recommend Noninvasive Prenatal Testing for Fetal Aneuploidy
6. Arctic Reaffirms the Value of Genetic Testing for Age-Related Macular Degeneration
7. NIH Awards New England Biolabs a Phase II SBIR Grant for the Research and Development of Novel Enzymes for Epigenetic Studies
8. Response Genetics, Inc. to Offer ROS1 Testing for Lung Cancer
9. Preimplantation Genetic Diagnosis (PGD) Market is Expected to Reach USD 47.4 Million Globally in 2018: Transparency Market Research
10. Human brains share a consistent genetic blueprint and possess enormous biochemical complexity
11. Epigenetics Holds Key to Healthier Future