Navigation Links
Genetic basis of high-risk childhood cancer points to possible new drug treatment strategy
Date:1/20/2013

linking low hypodiploid ALL to Li-Fraumeni syndrome came when researchers found the same TP53 mutation in two generations of the same family. The father was 31 years old when he was found to have a brain tumor associated with Li-Fraumeni syndrome. His son later developed low hypodiploid ALL.

"Identification of children with low-hypodiploid ALL and inherited TP53 mutations could help expand the use of life-saving cancer screening," said Linda Holmfeldt, Ph.D., a St. Jude postdoctoral fellow. She and Lei Wei, Ph.D., of the St. Jude Department of Computational Biology and formerly of Pathology, are the study's co-first authors. "Screening helps save lives by finding cancers much earlier when the odds of a cure are greatest," Holmfeldt said.

Investigators also reported deletions involving Ikaros gene family members that are rare in other ALL patients. The genes play a role in normal immune system development. The IKZF3 gene, also known as AIOLOS, was deleted in 13 percent of near haploid ALL patients. IKZF3 was deleted in nearly 53 percent of patients with low hypodiploid ALL.

Despite such differences, when researchers tested a variety of compounds against cells from both subtypes growing in the laboratory, they found compounds that targeted the PI3K pathway inhibited proliferation. Researchers are testing the effectiveness of these drugs in mouse models.

The authors are Ernesto Diaz-Flores and Mignon Loh , both of University of California School of Medicine, San Francisco; Michael Walsh , Jinghui Zhang , Debbie Payne-Turner , Michelle Churchman , Shann-Ching Chen , Kelly McCastlain , Jared Becksfort '/>"/>

SOURCE St. Jude Children's Research Hospital
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related biology technology :

1. Game changing diagnostic & prognostic prostate cancer genetic tests revealed by Jefferson
2. The Leading Edge Of Medical Innovation: New Prenatal Genetic Tests Use Moms Blood To Learn About Her Baby
3. GeneTex Launches New Antibody Against Phosphorylated Histone H3 for Epigenetics Research
4. Can a genetic variation in the vitamin D receptor protect against osteoporosis?
5. The American College of Obstetricians and Gynecologists Committee on Genetics and the Society for Maternal-Fetal Medicine Publications Committee Recommend Noninvasive Prenatal Testing for Fetal Aneuploidy
6. Arctic Reaffirms the Value of Genetic Testing for Age-Related Macular Degeneration
7. NIH Awards New England Biolabs a Phase II SBIR Grant for the Research and Development of Novel Enzymes for Epigenetic Studies
8. Response Genetics, Inc. to Offer ROS1 Testing for Lung Cancer
9. Preimplantation Genetic Diagnosis (PGD) Market is Expected to Reach USD 47.4 Million Globally in 2018: Transparency Market Research
10. Human brains share a consistent genetic blueprint and possess enormous biochemical complexity
11. Epigenetics Holds Key to Healthier Future
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... August 21, 2014 SoundConnect ... been recognized as one of the nation’s Fastest ... magazine for the 2nd consecutive year. Inc. magazine ... annual Inc. 500|5000, an exclusive ranking of the ... most comprehensive look at the most important segment ...
(Date:8/20/2014)... school history lessons often have it that American Indians ... cough, chicken pox, influenza and tuberculosis brought to the ... estimates vary, about 20 million people lived in the ... of them were killed by European diseases., But new ... State University and Johannes Krause of the University of ...
(Date:8/20/2014)... -- Decision Resources Group finds that the vascular access device market in ... India and China (BRIC) ... the size of the United States market ... faster growth as a result of strong economic expansion, improving access ... from Decision Resources Group,s coverage of the BRIC vascular access device ...
(Date:8/20/2014)... 2014 /PRNewswire-iReach/ -- A case study from Intel ... school,s bioengineering department and the Intel® Internet of ... Academic Program, UCSD,s research focuses on exploring the ... Photo - http://photos.prnewswire.com/prnh/20140819/137540 ... of Dr. Todd P. Coleman , Associate ...
Breaking Biology Technology:SoundConnect Returns on Inc. 5000 List of Fastest Growing Companies 2SoundConnect Returns on Inc. 5000 List of Fastest Growing Companies 3Unusual discovery leads to fascinating tuberculosis theory 2Unusual discovery leads to fascinating tuberculosis theory 3BRIC Vascular Access Device Market Valued at $1.6 Billion in 2013, Similar to the U.S. Market 2BRIC Vascular Access Device Market Valued at $1.6 Billion in 2013, Similar to the U.S. Market 3Intel and University of San Diego Bioengineering Department Release Case Study on Health Sciences Research 2
... is its new technology. Much of the technology for the ... enable it to see farther back in time. As with ... used to benefit humankind in many other industries. The ... to the Hubble Space Telescope. The most powerful space telescope ...
... MILFORD, Mass., April 18, 2012 SeraCare Life Sciences, ... sciences company providing vital products and services to facilitate ... therapeutics, announced that, at a special meeting of shareholders ... agreement with Project Plasma Holdings Corporation and Project Plasma ...
... Intellect Neurosciences, Inc. (OTCBB:ILNS), a biopharmaceutical company ... therapeutic agents for the treatment of Alzheimer,s and ... into a collaboration agreement with the University California, ... acting peptide vaccine candidate to induce an immune ...
Cached Biology Technology:Webb Telescope spinoff technologies already seen in some industries 2Webb Telescope spinoff technologies already seen in some industries 3Webb Telescope spinoff technologies already seen in some industries 4SeraCare Shareholders Approve Acquisition by Linden Capital Partners 2SeraCare Shareholders Approve Acquisition by Linden Capital Partners 3Intellect Neurosciences Enters Collaboration Agreement with Leading Alzheimer's Research Group at University of California Irvine to Test First in Class Dual Target Vaccine 2Intellect Neurosciences Enters Collaboration Agreement with Leading Alzheimer's Research Group at University of California Irvine to Test First in Class Dual Target Vaccine 3Intellect Neurosciences Enters Collaboration Agreement with Leading Alzheimer's Research Group at University of California Irvine to Test First in Class Dual Target Vaccine 4
(Date:8/21/2014)... a significant reduction in smog-producing toxins in past ... A new study shows that while the Greater ... the toxins that contribute to smog, the city ... air pollution., Smog, which can cause or aggravate ... bronchitis, is produced by a set of complex ...
(Date:8/21/2014)... but they are the ultimate source of all organic ... dependent on algae, too, to suck up climate-warming carbon ... bottom of the ocean. Now, by using a combination ... showing that viruses infecting those algae are driving the ... else stays essentially the same, and this has important ...
(Date:8/21/2014)... researchers from Beth Israel Deaconess Medical Center (BIDMC ) ... Most Influential Scientific Minds 2014," a comprehensive list ... web resource for science metrics and research performance analysis. ... most influential "are performing and publishing work that their ... science," according to a Thomson Reuters statement. Researchers were ...
Breaking Biology News(10 mins):Despite a significant reduction in smog-producing toxins, the Greater Toronto Area still violates Canada's standards for ozone air pollution 2Viruses take down massive algal blooms, with big implications for climate 2BIDMC researchers named among 'the most influential scientific minds' 2BIDMC researchers named among 'the most influential scientific minds' 3
... vaccine for visceral leishmaniasis, a parasitic disease that kills ... issue of ACS Chemical Biology . Spread by ... infects about 500,000 people annually, with the majority of ... , Despite a major research thrust by the World ...
... for speech through in-utero eavesdropping, or is their penchant ... but one that's central to understanding the origins and ... McGill University psychologist believes she's separated out the complicating ... says Dr. Athena Vouloumanos, point to a genetic predilection ...
... there's no picture in this kind of article , ... key role in activating the Epstein Barr Virus in human ... Molecular Biology Laboratory (EMBL) and the Institut de Virologie Moléculaire ... the CNRS, in Grenoble. , Like Sleeping Beauty, the Epstein ...
Cached Biology News:Potential vaccine developed for deadly leishmaniasis disease 2Potential vaccine developed for deadly leishmaniasis disease 3Born with a love of speech 2Born with a love of speech 3Waking a sleeping virus 2
... Custom monoclonal antibody development to targets including ... molecules, DNA, and cancer-specific surface antigens. ... and is completed in approximately 40 days ... nature of antigens). Phase I: Immunization, ...
... Clone/PAD: ZMD.460. Immunogen: Synthetic peptide ... human C35 protein (chromosome 17 open reading ... Specific for the C35 protein. On ... at ~15 kDa band. Reactivity: Human ...
... Peptide sequences: Two separate ... corresponding to the same sequence used ... antiserum (Catalog No. 160890) ... with Cayman's guanylate cyclase polyclonal antiserum ...
Immunogen: Secretory component isolated from human colostrum. Storage: 4 C...
Biology Products: