Navigation Links
Genetic basis of high-risk childhood cancer points to possible new drug treatment strategy
Date:1/20/2013

linking low hypodiploid ALL to Li-Fraumeni syndrome came when researchers found the same TP53 mutation in two generations of the same family. The father was 31 years old when he was found to have a brain tumor associated with Li-Fraumeni syndrome. His son later developed low hypodiploid ALL.

"Identification of children with low-hypodiploid ALL and inherited TP53 mutations could help expand the use of life-saving cancer screening," said Linda Holmfeldt, Ph.D., a St. Jude postdoctoral fellow. She and Lei Wei, Ph.D., of the St. Jude Department of Computational Biology and formerly of Pathology, are the study's co-first authors. "Screening helps save lives by finding cancers much earlier when the odds of a cure are greatest," Holmfeldt said.

Investigators also reported deletions involving Ikaros gene family members that are rare in other ALL patients. The genes play a role in normal immune system development. The IKZF3 gene, also known as AIOLOS, was deleted in 13 percent of near haploid ALL patients. IKZF3 was deleted in nearly 53 percent of patients with low hypodiploid ALL.

Despite such differences, when researchers tested a variety of compounds against cells from both subtypes growing in the laboratory, they found compounds that targeted the PI3K pathway inhibited proliferation. Researchers are testing the effectiveness of these drugs in mouse models.

The authors are Ernesto Diaz-Flores and Mignon Loh , both of University of California School of Medicine, San Francisco; Michael Walsh , Jinghui Zhang , Debbie Payne-Turner , Michelle Churchman , Shann-Ching Chen , Kelly McCastlain , Jared Becksfort '/>"/>

SOURCE St. Jude Children's Research Hospital
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related biology technology :

1. Game changing diagnostic & prognostic prostate cancer genetic tests revealed by Jefferson
2. The Leading Edge Of Medical Innovation: New Prenatal Genetic Tests Use Moms Blood To Learn About Her Baby
3. GeneTex Launches New Antibody Against Phosphorylated Histone H3 for Epigenetics Research
4. Can a genetic variation in the vitamin D receptor protect against osteoporosis?
5. The American College of Obstetricians and Gynecologists Committee on Genetics and the Society for Maternal-Fetal Medicine Publications Committee Recommend Noninvasive Prenatal Testing for Fetal Aneuploidy
6. Arctic Reaffirms the Value of Genetic Testing for Age-Related Macular Degeneration
7. NIH Awards New England Biolabs a Phase II SBIR Grant for the Research and Development of Novel Enzymes for Epigenetic Studies
8. Response Genetics, Inc. to Offer ROS1 Testing for Lung Cancer
9. Preimplantation Genetic Diagnosis (PGD) Market is Expected to Reach USD 47.4 Million Globally in 2018: Transparency Market Research
10. Human brains share a consistent genetic blueprint and possess enormous biochemical complexity
11. Epigenetics Holds Key to Healthier Future
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... , Jan. 22, 2015  Derma Sciences, Inc. (Nasdaq: ... focused on advanced wound care, announces that AMNIOEXCEL® ... have been added to the Premier, Inc. Regenerative ... opportunity for the AMNIOEXCEL® and AMNIOMATRIX® product lines, ...
(Date:12/24/2014)... and NEW YORK , Dec. 24, 2014 ... advancing patient care in critical areas, announced the closing of ... and warrants to purchase up to an aggregate 3,500,000 shares ... share and $.01 per warrant.  The warrants have a per ...
(Date:12/24/2014)... 23, 2014 “Preparative & Process ... Flash), Consumables (Columns, Solvents, Buffers, Valves, Guages, Seals), ... Agriculture) - Forecasts to 2019” provides a detailed ... current market trends, and strategies impacting the preparative ...
(Date:12/24/2014)... SoundConnect’s 2015 next ... edge communication technology, provide continued education and inform ... series demonstrates online communication features and benefits; empowering ... most innovative and powerful tools. , According to ...
Breaking Biology Technology:Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 2Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 3Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 5PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 2Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 4SoundConnect Launches Leading Edge Business Communications Webinar Series 2SoundConnect Launches Leading Edge Business Communications Webinar Series 3
... (DNA Diagnostics Center), the largest provider of private DNA paternity ... international attendees for a tour and behind the scenes look ... p.m. at DDC, One DDC Way, Fairfield, Ohio. ... International Exploration of Wrongful Conviction held in Cincinnati, Ohio, April ...
... diesel Capillary action and graphite foam are being ... a logistical nightmare for the military and U.S. troops deployed ... water a day, just getting that water to them increases ... proprietary system, however, this problem could be greatly reduced. The ...
... ALCLS), the genome engineering specialist, has announced today that its ... Depots (a French financial institution) for a planned capital investment ... to Cellectis and Caisse des Depots. This agreement ... subject to the achievement of certain technical conditions. ...
Cached Biology Technology:DDC to Name DNA Analyzer "Hello Truth" During Innocence Project International Delegate Tour 2Story tips from the Department of Energy's Oak Ridge National Laboratory: April 2011 2Story tips from the Department of Energy's Oak Ridge National Laboratory: April 2011 3Story tips from the Department of Energy's Oak Ridge National Laboratory: April 2011 4Cellectis and Caisse des Depots Sign Agreement on a Project for the Industrial Development of iPS Cells 2Cellectis and Caisse des Depots Sign Agreement on a Project for the Industrial Development of iPS Cells 3
(Date:1/22/2015)... DETROIT , Jan. 13, 2015 Technology Showcase, Hall ... iris-based identity authentication solutions, today announced it will showcase its ... and developed by the Department of Energy,s Oak Ridge ... International Auto Show . EyeLock,s iris identity authentication technology is ...
(Date:1/22/2015)... (NASDAQ: NXTD and NXTDW) a biometric authentication company focused ... the Wocket™ smart wallet at CES 2015 in Las Vegas ... of the "11 Hot Products at CES" in a review published in ... by Newseveryday.com and "The top 10 gadgets from CES 2015" by ...
(Date:1/22/2015)... MUNICH , January 22, 2015 ... its tenth year  The European Patent Office to present ... Two British nominations to be featured: Christofer Toumazou ... week featuring former finalists and winners of the Award   ...
Breaking Biology News(10 mins):EyeLock Debuts First Iris Authentication Technology Embedded in 3D Printed Automobile 2EyeLock Debuts First Iris Authentication Technology Embedded in 3D Printed Automobile 3CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 3Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 2Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 3
... -- In research published in the Jan. 17 issue of ... by Susana Gonzalo, Ph.D., assistant professor of biochemistry and molecular ... that contributes to triple-negative breast cancer, an often deadly and ... women. In addition, Gonzalo and her team identified vitamin D ...
... hands with antibacterial soap, most don,t think about where ... of Minnesota engineering researchers do. A new University ... called triclosan, used in soaps and many other products ... lakes. The findings are directly linked to increased triclosan ...
... Biologist Erica Larschan, Ph.D., was ... Month," for her innovative findings on chromosomal activity in fruit flies. ... at Brown University in identifying a protein that allows a male ... That advantage, if proven similar in human males, could point the ...
Cached Biology News:Vitamin D holds promise in battling a deadly breast cancer, Saint Louis University researchers say 2Vitamin D holds promise in battling a deadly breast cancer, Saint Louis University researchers say 3Vitamin D holds promise in battling a deadly breast cancer, Saint Louis University researchers say 4Antibacterial agent used in common soaps found in increasing amounts in freshwater lakes 2Antibacterial agent used in common soaps found in increasing amounts in freshwater lakes 3
Mouse polyclonal antibody to NR2F2 - nuclear receptor subfamily 2, group F, member 2...
Mouse polyclonal antibody raised against a partial recombinant MHC2TA. NCBI Entrez Gene ID = 4261...
... Smart Minis 300V power supply (Cat. No. ... voltage, sufficient for SDS-PAGE, and native PAGE ... pairs of terminator pairs can be used ... for individuals to have his/her own power ...
... NightOWL is a dedicated imaging system for ... Equipped with a very sensitive camera to ... plants in tumor research, infectious disease research, ... blots. NightOWL is the only imager with ...
Biology Products: