Navigation Links
Genetic Engineering and Biotechnology News (GEN) Reports on Mass Spec in Drug Discovery
Date:5/19/2008

NEW ROCHELLE, N.Y., May 19 /PRNewswire/ -- Mass spectrometry, driven by a broad range of improvements in hardware and software technologies, has given rise to an increasing number of applications in the clinic, according to an article in the May 15 issue of Genetic Engineering and Biotechnology News (GEN) (http://www.genengnews.com). Mass spec is also playing a greater role in drug discovery due to a growing focus on screening patients through the identification of biomarkers and developing more effective drugs based on structural properties of targets, reports the May 15 issue of GEN (http://www.genengnews.com/articles/chitem.aspx?aid=2469).

"Biomarker discovery has become a major trend for new drug discovery and development," notes John Sterling, Editor-in-Chief, GEN. "With advances continuing to take place in MS instrumentation regarding higher sensitivity, resolution, and throughput, it should come as no surprise that drug discovery scientists around the world are adopting this technique with more frequency."

Researchers at the Fred Hutchinson Cancer Research Center, for example, are working to discover cancer biomarkers using patient plasma samples. The proteins that really reflect disease development are low-abundance proteins, which are below the nanogram/mL level. To detect these rare proteins, Dr. Wang's group uses chromatogram-based protein fractionation first, followed by MS analysis.

Perhaps even more difficult to analyze than plasma, cerebral spinal fluid (CSF) poses different challenges. Fundamental studies, like others have done with plasma, need to be carried out to understand the nature of interfering compounds. At Lundbeck Research USA, triple quadrupole MS-MS is used to analyze CSF samples because it is the best way to do quantitative analysis in complex matrices.

Also covered in the GEN article is MS research in drug discovery taking place at Merck, Expression Pathology, Caprion Proteomics, and Wyeth.

For a copy of the May 15 issue of GEN, please call (914) 740-2122 or e-mail ebicovny@liebertpub.com

Genetic Engineering and Biotechnology News (http://www.genengnews.com), which is published 21 times a year by Mary Ann Liebert, Inc., is the most widely read biotechnology news magazine worldwide. It includes articles on Drug Discovery, Bioprocessing, OMICS, Biobusiness, and Clinical Research and Diagnostics.

Contact: John Sterling, Editor-in-Chief, GEN, Ph. 914-740-2196,

cell: 646-234-5118

E-mail: jsterling@genengnews.com


'/>"/>
SOURCE Genetic Engineering and Biotechnology News
Copyright©2008 PR Newswire.
All rights reserved

Related biology technology :

1. Digital Unions RT1(TM) Software Creates Telegenetics Network for Region 3 Genetics Collaborative
2. Response Genetics Reports Second Quarter 2007 Financial Results
3. ZymoGenetics Will Hold Conference Call Today at 5:00 p.m. Eastern Time to Provide Update on rThrombin
4. Clinical Data Acquires Epidauros Biotechnologie AG, Significantly Enhancing Proprietary Genetic Biomarker Portfolio
5. MedImmune Licenses Reverse Genetics Technology to Novartis for Use in Influenza Vaccine Development and Production
6. deCODE genetics to Webcast Presentation at Thomas Weisel Partners Annual Healthcare Conference
7. ZymoGenetics to Webcast Presentation at Two Upcoming Conferences
8. Interleukin Genetics Announces Management and Board Appointments
9. Response Genetics Announces Presentations/Webcasts at Upcoming Investor Conferences
10. Interleukin Genetics President and Chief Scientific Officer to Present at Immunotoxicology V Conference
11. CellCyte Genetics Corp. Forms Device Division to Develop and Manufacture Stem Cell Cultivation and Replication Products
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... -- Sequenom, Inc. (NASDAQ: SQNM ), a life ... development of innovative products and services, announced today that ... denied its petition to review decisions by ... Patent No. 6,258,540 (",540 Patent") are not patent eligible ... Court,s Mayo Collaborative Services v. Prometheus Laboratories decision.  In ...
(Date:6/27/2016)... Diego, CA (PRWEB) , ... June 27, 2016 , ... ... solutions for clinical trials, announced today the Clinical Reach Virtual Patient Encounter ... their care circle with the physician and clinical trial team. , Using the CONSULT ...
(Date:6/27/2016)... ... June 27, 2016 , ... Rolf K. ... the faculty of the University of North Carolina Kenan-Flagler Business School ... entrepreneurship at UNC Kenan-Flagler, with a focus on the school’s international efforts, leading ...
(Date:6/27/2016)... Ginkgo Bioworks , a leading organism design company ... as one of the World Economic Forum,s Technology ... companies. Ginkgo Bioworks is engineering biology to manufacture ... the nutrition, health and consumer goods sectors. The ... Fortune 500 companies to design microbes for their ...
Breaking Biology Technology:
(Date:3/23/2016)... March 23, 2016 ... Sicherheit Gesichts- und Stimmerkennung mit Passwörtern ... (NASDAQ: MESG ), ein führender Anbieter ... Unternehmen mit SpeechPro zusammenarbeitet, um erstmals dessen ... wird die Möglichkeit angeboten, im Rahmen mobiler ...
(Date:3/22/2016)... PROVO and SANDY, ... Screening Ontario (NSO), which operates the highest sample volume ... testing, and Tute Genomics and UNIConnect, leaders in clinical ... today announced the launch of a project to establish ... testing panel. NSO has been contracted ...
(Date:3/18/2016)... LONDON , March 18, 2016 ... Established Suppliers of Biometrics, ICT, Manned & Unmanned Vehicles, Physical ... & security companies in the border security market and ... and Europe has led ... your companies improved success. --> defence & ...
Breaking Biology News(10 mins):