Navigation Links
Genetic Engineering and Biotechnology News (GEN) Reports on Mass Spec in Drug Discovery
Date:5/19/2008

NEW ROCHELLE, N.Y., May 19 /PRNewswire/ -- Mass spectrometry, driven by a broad range of improvements in hardware and software technologies, has given rise to an increasing number of applications in the clinic, according to an article in the May 15 issue of Genetic Engineering and Biotechnology News (GEN) (http://www.genengnews.com). Mass spec is also playing a greater role in drug discovery due to a growing focus on screening patients through the identification of biomarkers and developing more effective drugs based on structural properties of targets, reports the May 15 issue of GEN (http://www.genengnews.com/articles/chitem.aspx?aid=2469).

"Biomarker discovery has become a major trend for new drug discovery and development," notes John Sterling, Editor-in-Chief, GEN. "With advances continuing to take place in MS instrumentation regarding higher sensitivity, resolution, and throughput, it should come as no surprise that drug discovery scientists around the world are adopting this technique with more frequency."

Researchers at the Fred Hutchinson Cancer Research Center, for example, are working to discover cancer biomarkers using patient plasma samples. The proteins that really reflect disease development are low-abundance proteins, which are below the nanogram/mL level. To detect these rare proteins, Dr. Wang's group uses chromatogram-based protein fractionation first, followed by MS analysis.

Perhaps even more difficult to analyze than plasma, cerebral spinal fluid (CSF) poses different challenges. Fundamental studies, like others have done with plasma, need to be carried out to understand the nature of interfering compounds. At Lundbeck Research USA, triple quadrupole MS-MS is used to analyze CSF samples because it is the best way to do quantitative analysis in complex matrices.

Also covered in the GEN article is MS research in drug discovery taking place at Merck, Expression Pathology, Caprion Proteomics, and Wyeth.

For a copy of the May 15 issue of GEN, please call (914) 740-2122 or e-mail ebicovny@liebertpub.com

Genetic Engineering and Biotechnology News (http://www.genengnews.com), which is published 21 times a year by Mary Ann Liebert, Inc., is the most widely read biotechnology news magazine worldwide. It includes articles on Drug Discovery, Bioprocessing, OMICS, Biobusiness, and Clinical Research and Diagnostics.

Contact: John Sterling, Editor-in-Chief, GEN, Ph. 914-740-2196,

cell: 646-234-5118

E-mail: jsterling@genengnews.com


'/>"/>
SOURCE Genetic Engineering and Biotechnology News
Copyright©2008 PR Newswire.
All rights reserved

Related biology technology :

1. Digital Unions RT1(TM) Software Creates Telegenetics Network for Region 3 Genetics Collaborative
2. Response Genetics Reports Second Quarter 2007 Financial Results
3. ZymoGenetics Will Hold Conference Call Today at 5:00 p.m. Eastern Time to Provide Update on rThrombin
4. Clinical Data Acquires Epidauros Biotechnologie AG, Significantly Enhancing Proprietary Genetic Biomarker Portfolio
5. MedImmune Licenses Reverse Genetics Technology to Novartis for Use in Influenza Vaccine Development and Production
6. deCODE genetics to Webcast Presentation at Thomas Weisel Partners Annual Healthcare Conference
7. ZymoGenetics to Webcast Presentation at Two Upcoming Conferences
8. Interleukin Genetics Announces Management and Board Appointments
9. Response Genetics Announces Presentations/Webcasts at Upcoming Investor Conferences
10. Interleukin Genetics President and Chief Scientific Officer to Present at Immunotoxicology V Conference
11. CellCyte Genetics Corp. Forms Device Division to Develop and Manufacture Stem Cell Cultivation and Replication Products
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2017)... ... ... to announce it has become the premiere team-building cooking event company in San Diego. ... as Illumina, HP and Qualcomm, and is ranked #1 in its category on Trip Advisor. ... new team building format, a way for teams to not only interact with one another ...
(Date:3/23/2017)... MILFORD, Mass. , March 23, 2017 ... leading partner to global in vitro diagnostics ... launch of the industry,s first multiplexed ... inherited disease testing by next-generation sequencing ... materials were developed with input from industry ...
(Date:3/23/2017)... ... March 23, 2017 , ... Ellen Matloff, president and ... Council (CTC) as a 2017 Women of Innovation® finalist. Matloff will be among ... Dinner. , The dinner recognizes women accomplished in science, technology, engineering and math ...
(Date:3/23/2017)... York , March 23, 2017 According ... plasma products and derivatives market is fragmented due to the presence of ... such as Proliant, Thermo Fisher , and Sigma-Aldrich, compete with ... these three companies, collectively, held more than 76% of this market ... As ...
Breaking Biology Technology:
(Date:3/22/2017)... 2017   Neurotechnology , a provider of ... announced the release of the SentiVeillance 6.0 ... facial recognition using up to 10 surveillance, security ... The new version uses deep neural-network-based facial detection ... utilizes a Graphing Processing Unit (GPU) for enhanced ...
(Date:3/20/2017)... At this year,s CeBIT Chancellor Dr. Angela Merkel visited ... to the DERMALOG stand together with the Japanese Prime Minster Shinzo Abe. ... the largest German biometrics company the two government leaders could see the ... well as DERMALOG´s multi-biometrics system.   Continue Reading ... ...
(Date:3/13/2017)... , March 13, 2017 Future of security: Biometric Face ... ... DERMALOGs Face Matching enables to match face pictures against ... basis to identify individuals. (PRNewsFoto/Dermalog Identification Systems) ... DERMALOG,s "Face Matching" is the fastest software for biometric Face Matching ...
Breaking Biology News(10 mins):