Navigation Links
Genetic Engineering and Biotechnology News (GEN) Reports on Early ADMET Use
Date:5/5/2008

NEW ROCHELLE, N.Y., May 5 /PRNewswire/ -- Biotech and pharma companies are increasingly utilizing novel technologies to assess the druggability of test compounds early in the development cycle to avoid costly late clinical-stage attrition, according to Genetic Engineering and Biotechnology News (GEN) (http://www.genengnews.com/). By identifying absorption, distribution, metabolism, excretion, and toxicity (ADMET) issues early, pharma also has the opportunity to increase the probability of success of its new drug development activities and reduce the time to market, reports the May 1 issue of GEN (http://www.genengnews.com/articles/chitem.aspx?aid=2460).

"With new drug development costs estimated at over $1 billion, it's imperative that biotech and pharma firms use ADMET tools intelligently and as early as possible in the drug discovery and development process to get a better handle on costs," notes John Sterling, Editor-in-Chief, GEN. "The intelligent application of ADMET studies could also go a long way to improving clinical trial results."

UCB Pharma, for example, uses a suite of validated assays and protocols to monitor the toxic characteristics of all small molecule compounds in its drug discovery pipeline. The company's in vitro toxicology team relies on cell-based assays to assess the cytotoxic potential of drug candidates using cell lines derived from human and rat hepatocytes.

CeeTox, a contract research organization, also takes a cell-based approach when looking at toxicity potential using a number of different cell models to assess not only hepatocellular-based toxic potential but also cardiotoxicity. The company introduced the use of neonate rat cardiomyocytes cultured in 96-well plates to monitor the potential for cardiotoxicity of a drug candidate.

Other companies covered in the GEN article include Affymetrix, Iconix, Sovicell, Apredica, MatTek, ChanTest, and EggCentris.

For a copy of the May 1, 2008 issue of GEN, please call (914) 740-2122, or e-mail: ebicovny@liebertpub.com

Genetic Engineering and Biotechnology News (http://www.genengnews.com), which is published 21 times a year by Mary Ann Liebert, Inc., is the most widely read biotechnology news magazine worldwide. It includes articles on Drug Discovery, Bioprocessing, OMICS, Biobusiness, and Clinical Research and Diagnostics.

Contact: John Sterling, Editor-in-Chief, GEN, Phone: 914-740-2196, Cell: 646-234-5118, E-mail: jsterling@genengnews.com


'/>"/>
SOURCE Genetic Engineering and Biotechnology News
Copyright©2008 PR Newswire.
All rights reserved

Related biology technology :

1. deCODE genetics Announces First Quarter 2008 Financial Results
2. Interleukin Genetics Appoints Eliot M. Lurier Chief Financial Officer
3. deCODE Discovers Fourth Major Set of Common Genetic Variants Linked to Risk of Estrogen Receptor-Positive Breast Cancer
4. deCODE Lauds Federal Legislation to Ban Discrimination on the Basis of Genetic Information
5. deCODE genetics Announces Webcast of Conference Call to Discuss First Quarter 2008 Financial Results
6. Genetic Testing for All: QTrait Offers Industrys Least Expensive, Most Secure DNA Tests With TRUSTe Certification
7. Genetic Engineering & Biotechnology News reports on growing use of cell-based assays
8. Sigma(R) Launches Innovative ChIP Kit Technology For Epigenetic Research
9. Genetic Engineering & Biotechnology News Reports on Growing Use of Cell-Based Assays
10. Genetic Engineering and Biotechnology News (GEN) Blog: International Students in the United States - A Diminishing Pool of Talent for Biotech?
11. Leading Geneticist Francis Collins Named First Recipient of the Inamori Ethics Prize at Case Western Reserve University
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/10/2016)... Feb. 10, 2016 NX Prenatal Inc., a ... NeXosome® technology for early warning of adverse pregnancy ... recent study by Dr. Thomas McElrath ... Maternal Fetal Medicine,s (SMFM) annual meeting held in ... , 2016.  The presentation reported initial positive top-line ...
(Date:2/10/2016)... -- Allergan plc (NYSE: AGN ) a leading global ... Allergan,s CEO and President, will be featured as the ... RBC Capital Markets Healthcare Conference on Tuesday, February 23, ... Palace Hotel in New York, NY ... be accessed on Allergan,s Investor Relations web site at ...
(Date:2/10/2016)... ... February 10, 2016 , ... LATHAM, NEW YORK... Marktech Optoelectronics ... West conference in San Francisco’s Moscone Center from February 16-18, 2016, and at ... , These latest InGaAs PIN diode standard packages feature a TO-46 metal can with ...
(Date:2/10/2016)... FL (PRWEB) , ... February 10, 2016 , ... ... in regenerative medicine, has announced a new agreement with Singapore-based Global Stem Cells ... physicians from the Philippines, Thailand and Singapore in the latest adipose and bone ...
Breaking Biology Technology:
(Date:1/21/2016)... 21, 2016 --> ... market research report "Emotion Detection and Recognition Market by Technology ... (Facial Expression, Voice Recognition and Others), Services, Application ... to 2020", published by MarketsandMarkets, the global Emotion ... USD 22.65 Billion by 2020, at a CAGR ...
(Date:1/15/2016)... 2016 Recent publicized breaches in cyber security ... ways to ensure data security and user authentication in ... Android that ties a user,s mobile number ... a hardware authorization token. Customer service agents who employ ... their KodeKey enabled device to verify their identity.  Companies ...
(Date:1/8/2016)... LOS ANGELES and MANCHESTER, United Kingdom ... ("BBI"), a developer of innovative sensor-based diagnostic products, today ... was financed by new and existing investors.  Proceeds from the ... SEM Scanner , a hand-held device for detecting early-stage ... and Ireland after receiving CE Mark ...
Breaking Biology News(10 mins):