Navigation Links
Genetic Engineering & Biotechnology News reports on novel hit-to-lead drug discovery
Date:7/8/2008

New Rochelle, NY, July 8, 2008Biotech and pharmaceutical firms are developing a host of new technologies designed to streamline the complicated drug discovery process, reports Genetic Engineering and Biotechnology News (GEN). Most successful approaches rely on a combination of high-throughput screening methods, miniaturization techniques, and advanced data-analysis tools, according to an article in the July issue (http://www.genengnews.com/articles/chitem.aspx?aid=2527) of GEN.

"The key goal for companies trying to develop new drugs is to find the best series of compounds that will optimize their chances of turning promising hits into even more promising leads," notes John Sterling, Editor in Chief of GEN.

Merck, for example, tries to make certain that its scientists work on physiologically relevant targets and assays during early-stage drug discovery research. For target identification the company uses RNAi technology in human cell lines. Multiparametric assays then generate biological activity profiles that can often provide valuable insight into complex disease models.

Pharmacopeia's screening platform is based on its ECLiPS (encoded combinatorial libraries on polymeric support) technology. Three steps are involved in the firm's screening process. A primary high-throughput approach screens eluate from multiple beads. A follow-up protocol screens single bead eluates from those sublibraries, which demonstrate activity in the assay. Finally, company scientists submit beads for a decoding process, which is how they identify the structure of compounds in the active wells in step two.

Also discussed in the GEN article is drug discovery activities taking place at GlaxoSmithKline, Fujifilm, Archemix, and the Southern Research Institute.


'/>"/>

Contact: John Sterling
jsterling@liebertpub.com
914-740-2196
Mary Ann Liebert, Inc./Genetic Engineering News
Source:Eurekalert

Page: 1

Related biology technology :

1. New technique produces genetically identical stem cells
2. deCODE genetics to Webcast Presentations at Annual R&D Event
3. deCODE genetics to Webcast Presentation at Piper Jaffray Europe Conference
4. Interleukin Genetics to Present at 2008 BIO International Convention
5. LabCorp(R) and Vanda Pharmaceuticals Collaborate to Offer Genetic Tests
6. CellCyte Genetics to Present at 2008 San Francisco RedChip Small-Cap Investor Conference
7. LI-COR(R) Biosciences and Tiger Woods Learning Center Collaborate to Develop High School Curriculum in Genetics
8. Interleukin Genetics to Present at the 13th International Conference on Periodontal Research
9. Gen-Probe Launches Cash Tender Offer to Acquire Belgian Molecular Diagnostics Company Innogenetics
10. Clarification on Press Release Issued Earlier Today: Targeted Genetics Confirms Positive, Interim Phase 1/2 Study Findings
11. CellCyte Genetics Corporation Announces Launch of Comprehensive Web site Powered by PRNewswire Investor Room Backend Technology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2016)... , May 26, 2016  Agriculture nutrients are in ... Moines, Iowa is running their nitrate removal ... Lake Erie and coastal regions nationwide are ... preventing this widespread issue. NECi Superior Enzymes, ... Upper Peninsula, developed a new, easy to use device ...
(Date:5/26/2016)... Jersey and READING, England ... Indegene ( http://www.indegene.com ), a leading global ... life science, pharmaceutical and healthcare organisations and TranScrip ... innovative scientific support throughout the product lifecycle, today ... the launch of IntraScience.      (Logo: ...
(Date:5/26/2016)... YORK , May 26, 2016 ... today that it will be a featured presenter at the ... in New York City at the ... Denis Corin , Q BioMed Inc. CEO, is scheduled to ... will cover the company,s business strategy, recent developments and outline ...
(Date:5/26/2016)... -- Despite the volatility that continues to envelop ... pre-market research on ActiveWallSt.com directs the investor community,s focus on ... RDUS ), Cerus Corp. (NASDAQ: CERS ), Arrowhead ... Therapeutics Inc. (NASDAQ: FPRX ). Register with us ... http://www.activewallst.com/ On Wednesday, shares in ...
Breaking Biology Technology:
(Date:5/24/2016)... IRVINE, Calif. , May 24, 2016 Ampronix facilitates superior patient care ... LMD3251MT  3D medical LCD display is the latest premium product recently added to ... ... ... Sony 3d Imaging- LCD Medical Display- Ampronix News ...
(Date:5/20/2016)... -- VoiceIt is excited to announce its new marketing ... working together, VoiceIt and VoicePass will offer an ... slightly different approaches to voice biometrics, collaboration between ... Both companies ... "This marketing and technology partnership allows VoiceIt ...
(Date:5/16/2016)... May 16, 2016   EyeLock LLC , a ... the opening of an IoT Center of Excellence in ... expand the development of embedded iris biometric applications. ... of convenience and security with unmatched biometric accuracy, making ... aside from DNA. EyeLock,s platform uses video technology to ...
Breaking Biology News(10 mins):