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Genetic Engineering & Biotechnology News Reports on Growing Use of Cell-Based Assays
Date:4/16/2008

NEW ROCHELLE, N.Y., April 16 /PRNewswire/ -- Biotech and pharma companies are increasingly relying on cell-based assays in early drug discovery work, reports Genetic Engineering & Biotechnology News (GEN). The technique can provide a quick and lower cost means of testing drug candidates for toxic effects, according to an article in the April 15 issue of GEN (http://www.genengnews.com/articles/chitem.aspx?aid=2437).

"Better screening technologies, noninvasive monitoring, and more automation are driving the trend toward adoption of this technology," notes John Sterling, Editor-in-Chief of GEN. "Some estimates project that the market for cell-based assays will more than double over the next six or seven years to over $230 million. This is definitely a methodology that should draw the interest of new drug developers."

More than 50% of currently marketed drugs target GPCRs, which impact a wide range of cellular processes. Multispan is looking to exploit this area and is collaborating with Promega and Molecular Devices to develop an array of applications for its GPCR cell-based assays.

Another field of much R&D interest involves protein-protein interactions. DiscoveRx created a new family of cell-based assays for the detection of protein-protein interactions using an enzyme fragment complementation assay. This system uses an enzyme acceptor, an inactive alpha-galactosidase enzyme that binds to its enzyme donor forming an active enzyme that will hydrolyze a substrate and provide a signal.

Other companies covered in the GEN article include Merck Research Laboratories, Sophion, Nanion, Novo Nordisk, ACEA Biosciences, and AstraZeneca.

For a copy of the April 15 issue of GEN, please call (914) 740-2122, or email: ebicovny@liebertpub.com

Genetic Engineering and Biotechnology News

SOURCE Genetic Engineering and Biotechnology News
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