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Generex Announces Publication on Application of Antigen Express Technology for Early Detection of Type 1 Diabetes
Date:5/3/2011

WORCESTER, Mass. and TORONTO, May 3, 2011 /PRNewswire/ -- Generex Biotechnology Corporation (www.generex.com) (OTCBB: GNBT) today announced publication of results of studies applicable to the early diagnosis, and possibly treatment of, Type 1 diabetes.  The study, entitled: "Recognition of Ii-Key/MHC Class II Epitope Hybrids Derived from Proinsulin and GAD Peptides by T Cells in Type 1 Diabetes" appears in the April issue of the international peer-reviewed journal Hormone and Metabolism Research.  The article reports on the results of a collaborative study between scientists in the laboratory of Professor Paolo Pozzilli at the University Campus Bio-Medico in Rome, Italy and scientists at Generex's wholly-owned subsidiary, Antigen Express, Inc. (www.antigenexpress.com).

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The methodology reported in the publication for identification of autoimmune cells in diabetic patients relies upon the Ii-Key technology developed at Antigen Express.  Specifically, attaching the Ii-Key segment to an antigenic peptide designed to activate CD4+ T helper cells increases the potency of the peptide while not altering its specificity.  To date, this technology has been used successfully to increase the potency of a variety of antigenic peptides.  The most advanced Ii-Key modified peptide clinically is a HER2 peptide that is currently in a Phase II clinical trial as an immunotherapeutic vaccine for patients with breast cancer.

In the case of Type 1 diabetes, autoimmunity is directed at insulin producing cells in the pancreas; in particular, towards the proinsulin and glutamic acid decarboxylase (GAD65) proteins.  The study reports that Ii-Key modified peptides from each of these proteins were ca
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