Navigation Links
Generex Announces Publication of Comparative Peptide Vaccine Studies in Peer Review Journal Demonstrating Superiority of AE37 and Presentation at the American Association for Cancer Research
Date:4/4/2011

WORCESTER, Mass. and TORONTO, April 4, 2011 /PRNewswire/ -- Generex Biotechnology Corporation (www.generex.com) (OTCBB: GNBT) announced today the publication of a report comparing the clinical characteristics of three different immunotherapeutic peptide vaccines designed for immunotherapy of breast cancer.  One of those, AE37, is being developed by the Company's wholly-owned subsidiary, Antigen Express, Inc. (www.antigenexpress.com).

(Logo: https://photos.prnewswire.com/prnh/20110106/NY25057LOGO-b)

The AE37 peptide, which is modified by proprietary technology to increase specific immunity against the HER2 protein expressed on cancer cells, is currently the subject of a randomized and controlled Phase II trial in patients with breast cancer as well as a Phase I trial in patients with prostate cancer that was recently completed.  

The report, entitled "Comparison of different HER2/neu vaccines in adjuvant breast cancer trials: implications for dosing of peptide vaccines", appeared in the February issue of Expert Review of Vaccines.  The three peptides compared were AE37, E75 (also known as NeuVax™) and GP2.  Both E75 and GP2 represent unmodified peptides derived from the HER2 protein selected to stimulate cytotoxic CD8+ T cells.  

In contrast, AE37 is a modified HER2-derived peptide designed to stimulate CD4+ T helper cells (in addition to CD8+ T cells).  All peptides were shown to be safe and well tolerated by breast cancer patients.  The order of potency of specific HER2 immunity induced by the peptides was: AE37 followed by GP2 followed by E75.  Though not yet confirmed, there is evidence suggesting that a better immunological response against HER2 is associated with decreased disease recurrence and mortality.

A further study is being presented at the 102nd Annual Meeting of the American Assoc
'/>"/>

SOURCE Generex Biotechnology Corporation
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related biology technology :

1. Generex Announces $3.0 Million Capital Investment
2. Generex Provides Additional Details for October 21st Live Video Webcast
3. Generex Common Stock to be Quoted on the OTCQB Under the Symbol GNBT Beginning Thursday, October 21, 2010
4. Generex Provides Additional Reverse Stock Split Information for the Consideration of Stockholders
5. Generex Scientific Advisor Weighs in on Reverse Stock Split Proposal
6. Generex Plans Rights Offering to Stockholders Following Reverse Stock Split
7. Generex Biotechnology Appoints Mark Fletcher as Interim President and CEO, and John P. Barratt as Chairman of the Board
8. Generex Announces That Adjournment will be Sole Matter Considered at Special Meeting of Stockholders on September 17, 2010
9. Crystal Research Associates, LLC Issues Executive Informational Overview(R) (EIO(R)) on Generex Biotechnology Corporation
10. Techne Corporation Announces Acquisition
11. Life Technologies Announces Launch of 2010 Online Annual Review
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/1/2015)... , April 1, 2015  ValGenesis Inc., the ... announced today that it has completed its Service Organization ... Attest Engagements (AICPA, Professional Standards) for the period of ... 2014.  ... The SOC 2 ...
(Date:4/1/2015)... 2015 Research and Markets ( ... "Blood Screening Market by Technology (Nucleic Acid ... Generation Sequencing, Western Blotting), Product (Instrument, Reagent) & ... 2019 " report to their offering. ... reach $2.55 billion by 2019 from $1.5 billion ...
(Date:4/1/2015)... DALLAS and NEW YORK ... Biopharmaceuticals, Inc. (NASDAQ:  PTBI), a biopharmaceutical company advancing ... today provided an overview of the Company,s 2014 ... highlighted achievements below demonstrate the progress the Company ... with multiple corporate partnerships for its MuGard programs, ...
(Date:4/1/2015)... The concept of “spot reducing” areas is a ... of Fasciology, Ashley Black, says that even the idea of ... having to wait for the whole fat system to reduce ... fat cooling procedures, the only well known way to ... is a highly invasive procedure.” It is common knowledge that ...
Breaking Biology Technology:ValGenesis Inc. Successfully Completes Service Organization Controls 2 (SOC 2) Report under AT Section 101 2ValGenesis Inc. Successfully Completes Service Organization Controls 2 (SOC 2) Report under AT Section 101 3Global Blood Screening (Nucleic Acid Amplification Test, ELISA, Rapid Test, Chemiluminescence Immunoassay, Next Generation Sequencing, Western Blotting) Market 2015-2019 2Global Blood Screening (Nucleic Acid Amplification Test, ELISA, Rapid Test, Chemiluminescence Immunoassay, Next Generation Sequencing, Western Blotting) Market 2015-2019 3PlasmaTech Biopharmaceuticals Provides Strategic Update for 2015 and Review of 2014 Acheivements 2PlasmaTech Biopharmaceuticals Provides Strategic Update for 2015 and Review of 2014 Acheivements 3PlasmaTech Biopharmaceuticals Provides Strategic Update for 2015 and Review of 2014 Acheivements 4PlasmaTech Biopharmaceuticals Provides Strategic Update for 2015 and Review of 2014 Acheivements 5PlasmaTech Biopharmaceuticals Provides Strategic Update for 2015 and Review of 2014 Acheivements 6Hybrid Health Guru, Ashley Black, announces that her invention The FasciaBlaster™ rivals the “fat cooling” procedures that reduce exercise and diet resistant fat pockets. 2Hybrid Health Guru, Ashley Black, announces that her invention The FasciaBlaster™ rivals the “fat cooling” procedures that reduce exercise and diet resistant fat pockets. 3
... ISU study, EPA analysis indicate vast potential for POET,s cellulosic process ... ... -- Corn cobs are both economical and environmentally friendly as a ... strategy for commercializing its new technology., , , , ,Removing corn ...
... Universal Definition of Myocardial Infarction provided jointly by ... Investigators from the Phase III TRITON-TIMI 38 ... Universal Definition of Myocardial Infarction to the results ... acute coronary syndromes (ACS) undergoing percutaneous coronary intervention ...
... Sky One Medical,Inc. ("China Sky One Medical" or ... leading,fully integrated pharmaceutical company in the People,s Republic ... agreement with Taiwan Golden,Biotechnology Corporation to begin cooperating ... Antroquinonol. , Golden Biotechnology ...
Cached Biology Technology:Research Reinforces Economic, Environmental Benefits of Corn Cobs as Source for Cellulosic Ethanol 2Research Reinforces Economic, Environmental Benefits of Corn Cobs as Source for Cellulosic Ethanol 3Multiple Types of Heart Attacks Reduced by Prasugrel in TRITON-TIMI 38 Trial 2Multiple Types of Heart Attacks Reduced by Prasugrel in TRITON-TIMI 38 Trial 3Multiple Types of Heart Attacks Reduced by Prasugrel in TRITON-TIMI 38 Trial 4Multiple Types of Heart Attacks Reduced by Prasugrel in TRITON-TIMI 38 Trial 5Multiple Types of Heart Attacks Reduced by Prasugrel in TRITON-TIMI 38 Trial 6China Sky One Medical, Inc. Signs Agreement with Taiwan Golden Biotechnology Corp. on Development of New Anti-Cancer Drug 2China Sky One Medical, Inc. Signs Agreement with Taiwan Golden Biotechnology Corp. on Development of New Anti-Cancer Drug 3
(Date:3/16/2015)... , March 16, 2015 ... GmbH will present groundbreaking innovations in biometric identification ... Germany .      (Photo: ... biometric innovation is well at the forefront: the ... e-gate made in Germany . ...
(Date:3/12/2015)... BERLIN , March 12, 2015 ... IAM, a standardized identity and access management (IAM) ... reliable implementation schedule. With Beta System,s new IAM ... and best practices gleaned from multiple IAM implementations ... includes the software as well as any necessary ...
(Date:3/11/2015)... March 11, 2015   The Sync Project™ ... to scientifically measure and harness music to improve ... biometrics and objective measurements of physiology, enabling the ... scale in large populations. It is designed for ... clinicians perform rigorous studies and accelerate the discovery ...
Breaking Biology News(10 mins):DERMALOG Presents its Latest Biometric Innovations at the Hannover CeBIT Exhibition, 16 - 20 March 2015 2DERMALOG Presents its Latest Biometric Innovations at the Hannover CeBIT Exhibition, 16 - 20 March 2015 3Beta Systems Fast Forward IAM Available Now: a Standardized IAM Package at a Fixed Price 2Introducing The Sync Project, a Global Collaboration Harnessing the Scientific Potential of Music for Health 2Introducing The Sync Project, a Global Collaboration Harnessing the Scientific Potential of Music for Health 3
... and farmers tending their fields can have in common chronic ... doses these agents, called organophosphates, are proven, rapid killers of ... as problems with learning and memory, headaches and pain, ... College of Georgia at Georgia Health Sciences University. ...
... to produce more energy from forest biomass may be ... scientists say in a new analysis that such large-scale ... increase greenhouse gas emissions. Early suggestions that such ... even reduce greenhouse emissions "are based on erroneous assumptions," ...
... Jellyfish are increasing in the majority of the world,s ... jellyfish abundance by University of British Columbia researchers. ... the journal Hydrobiologia , UBC scientists examined data ... world,s 66 Large Marine Ecosystems. They found increasing jellyfish ...
Cached Biology News:Effect of chronic exposure to chemicals used as weapons, pesticides under study 2Effect of chronic exposure to chemicals used as weapons, pesticides under study 3Analysis raises atmospheric, ecologic and economic doubts about forest bioenergy 2Analysis raises atmospheric, ecologic and economic doubts about forest bioenergy 3Jellyfish on the rise: UBC study 2
... for Vector NTI allows you to store ... biology data in a secure central relational ... way creates an invaluable resource for clone ... data easily for immediate analysis. LabShare software ...
... Time-resolved microscopy is the ultimate tool for ... structures. Its applications previously have been limited ... microscope optics do not transmit in the ... in fluorescence spectroscopy, introduces a filter-based confocal ...
... CLS number is a new ... match Cornings product number. If ... order under the old Sigma-Aldrich ... service for assistance. ID clarifier: ...
... involves using many of the automation concepts ... handling requirements are similar to those for ... have 24 or 48 wells with well ... throughput, the number of wells has increased ...
Biology Products: