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Generex Announces Publication of Comparative Peptide Vaccine Studies in Peer Review Journal Demonstrating Superiority of AE37 and Presentation at the American Association for Cancer Research
Date:4/4/2011

WORCESTER, Mass. and TORONTO, April 4, 2011 /PRNewswire/ -- Generex Biotechnology Corporation (www.generex.com) (OTCBB: GNBT) announced today the publication of a report comparing the clinical characteristics of three different immunotherapeutic peptide vaccines designed for immunotherapy of breast cancer.  One of those, AE37, is being developed by the Company's wholly-owned subsidiary, Antigen Express, Inc. (www.antigenexpress.com).

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The AE37 peptide, which is modified by proprietary technology to increase specific immunity against the HER2 protein expressed on cancer cells, is currently the subject of a randomized and controlled Phase II trial in patients with breast cancer as well as a Phase I trial in patients with prostate cancer that was recently completed.  

The report, entitled "Comparison of different HER2/neu vaccines in adjuvant breast cancer trials: implications for dosing of peptide vaccines", appeared in the February issue of Expert Review of Vaccines.  The three peptides compared were AE37, E75 (also known as NeuVax™) and GP2.  Both E75 and GP2 represent unmodified peptides derived from the HER2 protein selected to stimulate cytotoxic CD8+ T cells.  

In contrast, AE37 is a modified HER2-derived peptide designed to stimulate CD4+ T helper cells (in addition to CD8+ T cells).  All peptides were shown to be safe and well tolerated by breast cancer patients.  The order of potency of specific HER2 immunity induced by the peptides was: AE37 followed by GP2 followed by E75.  Though not yet confirmed, there is evidence suggesting that a better immunological response against HER2 is associated with decreased disease recurrence and mortality.

A further study is being presented at the 102nd Annual Meeting of the American Assoc
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SOURCE Generex Biotechnology Corporation
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