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Generex Announces Publication of AE37 Prostate Cancer Vaccine Study
Date:8/6/2014

WORCESTER, Mass. and TORONTO, Aug. 6, 2014 /PRNewswire/ -- Generex Biotechnology Corporation (www.generex.com) (OTCBB:GNBT) today announced publication of a follow-up study from a Phase I clinical trial of the immunotherapeutic agent AE37 in patients with prostate cancer.  The study demonstrates an association between a specific immune response generated by AE37 and improved overall survival.  The compound is being developed by Antigen Express, Inc. (www.antigenexpress.com), a wholly-owned subsidiary of Generex, for multiple cancer indications.

The publication, entitled, "AE37 peptide vaccination in prostate cancer: identification of biomarkers in the context of prognosis and prediction," appears in the peer-reviewed journal Cancer Immunology, Immunotherapy, a forum for new concepts and advances in basic, translational, and clinical cancer immunology and immunotherapy (online publication July 23, 2014).  While a prior study showed that AE37-immunized patients had better overall and disease-free survival as a group than would be expected from their disease status, the current study shows that patients with the strongest immunological response did the best.  In particular, both the presence of AE37-induced T cells in peripheral blood as well as a robust delayed type hypersensitivity (DTH) response elicited by AE37 correlated significantly with overall survival.  The authors point out the importance of CD4+ T cells in developing a good DTH response.  AE37 was developed using the Antigen Express Ii-Key technology platform that ensures robust, specific CD4+ T cell activation.

The current report expands upon prior studies on the results of a Phase I trial of AE37 in patients with prostate cancer.  AE37 is also the subject of a controlled, randomized Phase II trial t
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SOURCE Generex Biotechnology Corporation
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3. Generex/Antigen Express Announce Database Lock of AE37 Breast Cancer Vaccine Trial
4. Generex Confirms Conference Call with Members of the Antigen Express Scientific Advisory Board
5. Generex Announces Particulars of Conference Call with Members of the Antigen Express Scientific Advisory Board
6. Generex Announces Scheduling of USFDA End-of-Phase II Meeting for the AE37 Breast Cancer Vaccine
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9. Generex Subsidiary Antigen Express Announces Press Conference at American Association for Cancer Research Related to the Immunological Response of its AE37 Vaccine to Prevent Recurrence of Breast Cancer
10. Generex Announces Patent Award for its Core Vaccine Technologies in Japan
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