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Genedata Phylosopher Selected for ERA-NET sncRNA Project
Date:6/1/2010

get validation,” explained Dr. Torsten Hain of the University of Giessen (Germany) and sncRNAomics Project Coordinator. “In health care, and especially in a clinical environment, microbial resistance increases exponentially. Antibiotics have become a blunt sword and we need new approaches in diagnostics and therapy,” continued Dr. Hain. “Small non-coding RNAs in bacteria are an emerging class of new gene expression regulators, but their role in colonization and pathogenicity is largely unknown. Within this interdisciplinary project we are applying for the first time a systems biology approach on major human pathogens to elucidate the role of sncRNAs, and to identify and validate new sncRNA-based diagnostic biomarkers and drug targets.”

Genedata Phylosopher will integrate all experimental data from the pathogens and the host organisms. Using a genome-wide scale and regulatory network approach, the consortium will adapt high-throughput technologies such as transcriptomics by tiling arrays as well as next-generation sequencing technologies to identify novel sncRNAs and to investigate their role in regulation. Genedata Phylosopher supports the reconstruction of disease pathways, in particular the refinement of functional assignment of genes, transcripts, proteins, regulatory motifs, RNAs and their molecular interactions, to regulatory networks during host-pathogen interactions.

"We are delighted to have this international and interdisciplinary consortium choose Genedata as their central data management and analysis infrastructure,” said Dr. Othmar Pfannes, CEO of Genedata. “This partnership further demonstrates Genedata’s leadership in delivering scalable and flexible

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