Navigation Links
GeneTex Introduces New Mouse Monoclonal Antibody Against the Ten-Eleven Translocation 1 (TET1) Protein for DNA Methylation/Epigenetics Research
Date:5/8/2013

IRVINE, Calif., May 8, 2013 /PRNewswire/ -- GeneTex, Inc., a leading manufacturer of antibodies and antibody-related reagents, is introducing a new mouse monoclonal antibody to the human Ten-Eleven Translocation 1 (TET1) protein. The discovery in 2009 (Tahiliani et al, 2009) that this enzyme can convert the DNA methylation mark 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) helped to usher in a new field of research in epigenetics.  Since then, it has become clear that TET1 and its family members TET2 and TET3, through the oxidation of 5mC to 5hmC, 5-formylcytosine (5fC), or 5-carboxylcytosine (5caC), are pivotal factors in epigenetic signaling.

(Logo: http://photos.prnewswire.com/prnh/20111129/LA13485LOGO-b)

The excitement generated by the mammalian TET proteins in the last few years is due to their impact on the regulation of DNA methylation, a fundamental epigenetic mechanism that generally causes genes to be turned off through direct methylation of particular cytosines (5mC) in the DNA sequence. The enzymes responsible for this DNA methylation, termed DNA methyltransferases (DNMTs), have been identified and characterized. However, how DNA could be actively demethylated remained a puzzle. It is now thought that the TET enzymes are intimately involved in this process through the conversion of 5mC to 5hmC, 5fC, and 5caC, essentially forming a stepwise pathway to demethylation. Thus, the actions of these enzymes facilitate dynamic regulation of DNA methylation, with the readily apparent implications for development and carcinogenesis.  Even more intriguing to epigenetics researchers, however, is the growing appreciation that these 5mC derivatives, in particular 5hmC, are epigenetic signals in their own right.

TET1 is known to be a challenging protein to develop quality antibodies against and GeneTex is pleased to announce a first to market mouse monoclonal TET1 antibody [GT1462] (GTX627420) that is the most extensively characterized commercially available TET1 antibody.  Qualitative validation has demonstrated that this antibody can detect the human TET1 protein in ICC/IF, IHC-P, and western blot applications.  Importantly, its specificity was verified by both overexpression and siRNA studies. GeneTex also produces polyclonal antibodies against TET1 as well as additional antibodies to TET2, TET3, and 5mC. For more information on GeneTex, Inc. and its products, please call toll-free 877-GENETEX (436-3839) or visit www.genetex.com.

About GeneTex, Inc.

GeneTex, Inc. is an antibody manufacturing company founded in 1997 by a group of internationally renowned academic scientists. They strive to produce the highest quality antibodies and reagents. Their primary and secondary antibodies are created through a process involving extensive research, development, and validation. GeneTex's catalog has grown to over 55,000 primary antibodies and supportive reagents, which are all backed with a 100% Satisfaction Guarantee.

Corporate Mission

We strive to serve and accelerate life science research by creating essential life science tools where quality can be found in every vial.


'/>"/>
SOURCE GeneTex, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Related biology technology :

1. GeneTex Antibody Company to Launch New Line of Primary Antibodies for the Study of Spindle Assembly
2. GeneTex, Inc. to Attend the 2012 Annual Meeting of the American Society for Cell Biology
3. GeneTex Launches New Antibody Against Phosphorylated Histone H3 for Epigenetics Research
4. New England Biolabs Introduces Polbase, an Information Repository of Scientific Data for Polymerase Researchers
5. PAREXEL Introduces Executive Briefing Series on Proven Practices to Assist Emerging and Mid-size Biopharma in Achieving Better Outcomes
6. Leading Pharmaceutical Marketing Research and Consulting Company Introduces Intelligent Efficiency Program
7. NextGen introduces its first generation of animal biomarker products for development of brain disorder diagnostics
8. WHEATON® Introduces a New Web Community for Scientists, Researchers, and Biopharmaceutical Packagers
9. Profit Lifter for Pro Mold Removers: Molderizer Introduces Remediation Product Like No Other
10. JPSA Introduces Picosecond Laser Micromachining System
11. Vision Research Introduces the Newest Member Of the Phantom®- 1Mpx- v-Series Camera Family
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... Epic Sciences unveiled a liquid biopsy ... PARP inhibitors by targeting homologous recombination deficiency (HRD) ... test has already been incorporated into numerous clinical ... Over 230 clinical trials are investigating ... PARP, ATM, ATR, DNA-PK and WEE-1. Drugs targeting ...
(Date:6/23/2016)... ... June 23, 2016 , ... UAS LifeSciences, one of the ... brand, UP4™ Probiotics, into Target stores nationwide. The company, which has been manufacturing ... to its list of well-respected retailers. This list includes such fine stores as ...
(Date:6/23/2016)... June 23, 2016 Houston Methodist Willowbrook ... Cy-Fair Sports Association to serve as their official ... Houston Methodist Willowbrook will provide sponsorship support, athletic ... with association coaches, volunteers, athletes and families. ... Cy-Fair Sports Association and to bring Houston Methodist ...
(Date:6/23/2016)... , June 23, 2016   EpiBiome , a ... $1 million in debt financing from Silicon Valley Bank ... automation and to advance its drug development efforts, as ... facility. "SVB has been an incredible strategic ... services a traditional bank would provide," said Dr. ...
Breaking Biology Technology:
(Date:4/15/2016)... , April 15, 2016  A new partnership ... more accurate underwriting decisions in a fraction of ... competitively priced and high-value life insurance policies to ... With Force Diagnostics, rapid testing (A1C, ... data readings (blood pressure, weight, pulse, BMI, and ...
(Date:4/14/2016)... TEL AVIV, Israel , April 14, 2016 /PRNewswire/ ... in Behavioral Authentication and Malware Detection, today announced the ... has already assumed the new role. Goldwerger,s ... for BioCatch, on the heels of the deployment of ... In addition, BioCatch,s behavioral biometric technology, which discerns unique ...
(Date:3/31/2016)... BOCA RATON, Florida , March 31, 2016 /PRNewswire/ ... LEGX ) ("LegacyXChange" or the "Company") ... presentation for potential users of its soon to be ... The video ( https://www.youtube.com/channel/UCyTLBzmZogV1y2D6bDkBX5g ) will also ... by the use of DNA technology to an industry ...
Breaking Biology News(10 mins):