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GeneTex Introduces New Mouse Monoclonal Antibody Against the Ten-Eleven Translocation 1 (TET1) Protein for DNA Methylation/Epigenetics Research
Date:5/8/2013

IRVINE, Calif., May 8, 2013 /PRNewswire/ -- GeneTex, Inc., a leading manufacturer of antibodies and antibody-related reagents, is introducing a new mouse monoclonal antibody to the human Ten-Eleven Translocation 1 (TET1) protein. The discovery in 2009 (Tahiliani et al, 2009) that this enzyme can convert the DNA methylation mark 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) helped to usher in a new field of research in epigenetics.  Since then, it has become clear that TET1 and its family members TET2 and TET3, through the oxidation of 5mC to 5hmC, 5-formylcytosine (5fC), or 5-carboxylcytosine (5caC), are pivotal factors in epigenetic signaling.

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The excitement generated by the mammalian TET proteins in the last few years is due to their impact on the regulation of DNA methylation, a fundamental epigenetic mechanism that generally causes genes to be turned off through direct methylation of particular cytosines (5mC) in the DNA sequence. The enzymes responsible for this DNA methylation, termed DNA methyltransferases (DNMTs), have been identified and characterized. However, how DNA could be actively demethylated remained a puzzle. It is now thought that the TET enzymes are intimately involved in this process through the conversion of 5mC to 5hmC, 5fC, and 5caC, essentially forming a stepwise pathway to demethylation. Thus, the actions of these enzymes facilitate dynamic regulation of DNA methylation, with the readily apparent implications for development and carcinogenesis.  Even more intriguing to epigenetics researchers, however, is the growing appreciation that these 5mC derivatives, in particular 5hmC, are epigenetic signals in their own right.

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