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GeneNews reports positive results from validation study of colorectal cancer biomarkers in late-breaking abstract at AACR
Date:4/14/2008

fication could encourage more individuals to undergo screening. This could lead to earlier detection of colorectal cancer, thereby reducing suffering and death." Dr. Levin is the Chair of the Company's Colorectal Cancer Clinical Advisory Board.

Colorectal cancer is the second leading cause of cancer deaths in both men and women and the most common cause of cancer deaths in non-smokers. It is recommended that all individuals over the age of 50 undergo screening for colorectal cancer and pre-cancerous polyps on a regular basis. In the US, there are approximately 80 million people who are over the age of fifty.

The abstract, entitled "Stratification of colorectal cancer probability using six genes from whole blood" is being presented at the American Association for Cancer Research (AACR) Annual Meeting, in the Clinical Research 2 session, Poster Section 19, on Tuesday, April 15, 2008 at 8:00 AM. The abstract describes how RNA expression profiling of blood samples from a training set of 243 colorectal cancer and normal control patients was used to identify a combination of six biomarkers informative for stratifying the probability of having colorectal cancer in an average risk population. The performance of these six biomarkers was validated in a blind test set population of 337 colorectal cancer and control patients. The combined training/blind set had an average AUC (Area under the Curve) = 0.78% (95%CI: 0.73 to 0.84) and an average accuracy of 70.8% (95%CI: 65.3% to 76.2%).

About GeneNews

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GeneNews is focused on the application of functional genomics to enable early diagnosis and personalized therapeutic intervention based on disease-specific biomarkers. The Company has developed a novel approach, the Sentinel Principle(TM), to detect and stage virtually any disease or medical condition from a simple blood sample. GeneNews is currently applying the Sentinel Principle(TM) in major areas with unmet clinical needs such as
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