Navigation Links
GeneNews reports positive results from validation study of colorectal cancer biomarkers in late-breaking abstract at AACR

- Biomarkers form basis of blood-based ColonSentry(TM) test -

TORONTO, April 14 /PRNewswire-FirstCall/ - GeneNews Limited (TSX: GEN), a company focused on developing blood-based biomarker tests for the early detection of diseases and personalized health management, today reported positive performance results from a large validation study of a six-gene biomarker panel for the assessment of a patient's current risk for colorectal cancer. This panel forms the basis of the Company's lead product, ColonSentry(TM), which is planned for launch in Canada in the third quarter of 2008 as a laboratory-developed test.

The validation study confirmed (p less than 0.05) that the panel was able to stratify a population with average risk for colorectal cancer into three groups:
- Increased Probability: 18% of the population were defined as having a

3-fold increased probability of currently having colorectal cancer.

- Average Probability: 20% were defined as having an average probability

of currently having colorectal cancer.

- Decreased Probability: 62% were defined as having a 4-fold decreased

probability of currently having colorectal cancer.

"There is a need for a patient friendly test that can assess an individual's current risk for colorectal cancer, thereby enabling average risk patients to be stratified into more defined groups. This stratification would facilitate shared decision-making by physicians and their patients around screening options," commented Dr. Bernard Levin, an internationally recognized expert in colorectal cancer screening. "Although colorectal cancer can often be cured if detected early by screening, the majority of individuals do not comply willingly with screening recommendations because they find the screening methods such as stool tests or invasive endoscopic or radiologic procedures to be unpleasant or inconvenient. A blood test is more familiar and based on risk stratification could encourage more individuals to undergo screening. This could lead to earlier detection of colorectal cancer, thereby reducing suffering and death." Dr. Levin is the Chair of the Company's Colorectal Cancer Clinical Advisory Board.

Colorectal cancer is the second leading cause of cancer deaths in both men and women and the most common cause of cancer deaths in non-smokers. It is recommended that all individuals over the age of 50 undergo screening for colorectal cancer and pre-cancerous polyps on a regular basis. In the US, there are approximately 80 million people who are over the age of fifty.

The abstract, entitled "Stratification of colorectal cancer probability using six genes from whole blood" is being presented at the American Association for Cancer Research (AACR) Annual Meeting, in the Clinical Research 2 session, Poster Section 19, on Tuesday, April 15, 2008 at 8:00 AM. The abstract describes how RNA expression profiling of blood samples from a training set of 243 colorectal cancer and normal control patients was used to identify a combination of six biomarkers informative for stratifying the probability of having colorectal cancer in an average risk population. The performance of these six biomarkers was validated in a blind test set population of 337 colorectal cancer and control patients. The combined training/blind set had an average AUC (Area under the Curve) = 0.78% (95%CI: 0.73 to 0.84) and an average accuracy of 70.8% (95%CI: 65.3% to 76.2%).

About GeneNews


GeneNews is focused on the application of functional genomics to enable early diagnosis and personalized therapeutic intervention based on disease-specific biomarkers. The Company has developed a novel approach, the Sentinel Principle(TM), to detect and stage virtually any disease or medical condition from a simple blood sample. GeneNews is currently applying the Sentinel Principle(TM) in major areas with unmet clinical needs such as cancer, arthritis, cardiovascular disease and neurological disorders. GeneNews' first product in development, ColonSentry(TM), is a convenient and patient-friendly blood-based test that can assess an individual's current risk for colorectal cancer. For more information on GeneNews, visit

This press release contains forward-looking statements, which reflect the Company's current expectations regarding future events. The forward-looking statements involve risks and uncertainties. Actual events could differ materially from those projected herein. Investors should consult the Company's ongoing quarterly filings and annual reports for additional information on risks and uncertainties relating to these forward-looking statements. The reader is cautioned not to rely on these forward-looking statements. The Company disclaims any obligation to update these forward-looking statements.

SOURCE GeneNews Limited
Copyright©2008 PR Newswire.
All rights reserved

Related biology technology :

1. GeneNews announces 2007 year end results
2. GeneNews selected to present late-breaking abstract at AACR Annual Meeting
3. GeneNews receives ISO 13485 accreditation
4. GeneNews initiates patient sample accrual for validation studies of colon cancer blood test
5. GeneNews Chief Scientist Dr. C.C. Liew co-editor of new genomics reference book
6. GeneNews CSO Dr. CC Liew awarded state honour by the Government of Malaysia
7. Cryo-Cell International, Inc. Reports First Quarter 2008 Results
8. Oncolytics Biotech Inc. Reports Positive Interim Results of U.K. Combination REOLYSIN(R) and Carboplatin/Paclitaxel Trial
9. Sangui BioTech International, Inc., Reports Sales Increase, Continued Losses
10. Chem Rx Corporation Reports Full Year 2007 Financial Results
11. Spherix Reports 2007 Financial Results
Post Your Comments:
(Date:10/12/2015)... October 12, 2015 LabStyle Innovations ... Management Solution, today announced its Medical Director, Dr. ... at MobiHealth,s 5th EAI International Conference on Wireless ... through innovations in mobile and wireless technologies," the conference ... from October 14 - 16, 2015. The conference ...
(Date:10/12/2015)... ... , ... NeuMedics Inc., is a specialty biopharmaceutical company focused on identifying and ... be administered as an eye drop, announced today it has been selected to present ... place October 25th to October 28th at The Cleveland Clinic, Cleveland, Ohio. The ...
(Date:10/10/2015)... Oktober, 2015 Am 8. Oktober hat ... Partei für Kalifornien) ihre Würdigung der International Plasma ... die Aufzeichnungen des Kongresses eintragen lassen. Die IPAW ... (PPTA) und ihren Mitgliedsunternehmen unterstützt. Ihre Ziele ... Bewusstseins über Plasmaspenden weltweit , Würdigung des ...
(Date:10/9/2015)... 9, 2015  DePuy Synthes Trauma* announced today the ... ®  Technology**, the only pre-hydrated demineralized cancellous bone ... (foot and ankle, hand and wrist), including fusion, and ... at the 2015 Orthopaedic Trauma Association (OTA) Annual Meeting. ... for new bone growth) and osteoinductive 2,3 (stimulates ...
Breaking Biology Technology:
(Date:9/28/2015)... 28, 2015  The monitoring of vital signs, ... temperature, is an essential component of patient assessment. ... deterioration in a patient,s condition. However, in general ... typically taken during routine observation rounds only once ... deteriorates between these observation rounds, the warning signs ...
(Date:9/26/2015)... 2015  Results of a TactioRPM pilot project ... at the Stanford Medicine X Conference. In a ... Connected Health Devices and Pharmacogenomics", Roger Simard ... explain how senior patients equipped with connected health ... via the TactioRPM remote patient monitoring platform were ...
(Date:9/10/2015)... 2015 Report Details Emerging ... Opportunities and Revenue Prospects to Help You Stay ... especially new drug classes? Get the latest technological ... exclusive market data and industry knowledge, benefitting your ... opportunities and sales predictions. Visiongain,s new study ...
Breaking Biology News(10 mins):