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Gene Therapy - Technologies, Markets and Companies

rders 335

8. Gene therapy of viral infections 338

Introduction 338

Acquired Immunodeficiency Syndrome (AIDS) 338

Current management of AIDS 338

Gene therapy strategies in HIV/AIDS 339

HIV/AIDS vaccines 339

Insertion of protective genes into target cells. 340

Cell/gene therapies for HIV/AIDS 341

Transplantation of genetically modified T-cells 341

Transplantation of genetically modified hematopoietic cells 341

Anti-HIV ribozyme delivered in hematopoietic progenitor cells 342

Inhibition of HIV-1 replication by lentiviral vectors 342

VRX496 342

Intracellular immunization 343

Engineered cellular proteins such as soluble CD4s 343

Intracellular antibodies 343

Anti-rev single chain antibody fragment 343

Use of genes to chemosensitize HIV-1 infected cells 344

Autocrine interferon (INF)-? production by somatic cell gene therapy 344

Antisense approaches to AIDS 344

RNA decoys 344

Antisense oligodeoxynucleotides 344

RNA decoys 345

Ribozymes 345

RNAi applications in HIV/AIDS 346

siRNA-directed inhibition of HIV-1 infection 346

Role of the nef gene during HIV-1 infection and RNAi 346

Bispecific siRNA constructs 347

Targeting CXCR4 with siRNAs 347

Targeting CCR5 with siRNAs 347

Companies involved in developing gene therapy for HIV/AIDS 348

Conclusions regarding gene therapy of HIV/AIDS 349

Genetic vaccines for other viral infections 349

Cytomegalic virus infections 349

Viral hepatitis 350

Vaccine for hepatitis B virus 350

Vaccine for hepatitis C virus 351

Vaccine for herpes simplex virus 351

DNA vaccine against rabies 351

DNA vaccine for Ebola 352

Vaccines for avian influenza 352

Future prospects of DNA vaccines for avian influenza 353

Human trial of a DNA vaccine for avian influenza 3

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