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Gene Therapy - Technologies, Markets and Companies

c disorders predisposing to atherosclerosis 317

Familial hypercholesterolemia (FH) 317

Apolipoprotein E (apoE) deficiency 319

Hypertension 319

Genetic factors for myocardial infarction 320

Acquired cardiovascular diseases 320

Coronary artery disease with angina pectoris 320

Ad5FGF-4 320

Ischemic heart disease with myocardial infarction 321

Myocardial repair with IGF-1 therapy 322

Metalloproteinase-2 inhibitor gene therapy 323

miRNA gene therapy for ischemic heart disease 323

Congestive heart failure 323

Rationale of gene therapy in CHF 323

?-ARKct gene therapy 324

Intracoronary adenovirus-mediated gene therapy for CHF 324

AAV-mediated gene transfer for CHF 325

AngioCell gene therapy for CHF 325

nNOS gene transfer in CHF 326

Cardiomyopathies 326

Cardiac conduction disturbances 326

Gene transfer approaches for biological pacemakers 326

Genetically engineered biological pacemakers 327

Gene therapy and heart transplantation 327

Peripheral arterial disease 328

Incidence and clinical features 328

Current management 328

Gene therapy for peripheral arterial disease 329

Angiogenesis by gene therapy 329

HIF-1? gene therapy for peripheral arterial disease 329

HGF gene therapy for peripheral arterial disease 330

Ischemic neuropathy secondary to peripheral arterial disease 330

Prevention of restenosis after angioplasty 330

Antisense approaches 331

Gene therapy to prevent restenosis after angioplasty 331

Techniques of gene therapy for restenosis 332

NOS gene therapy for restenosis 333

hTIMP-1 gene therapy to prevent intimal hyperplasia 334

Maintaining vascular patency after surgery 334

Companies involved in gene therapy of cardiovascular diseases 334

Future prospects of gene therapy of cardiovascular diso

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