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Gene Therapy - Technologies, Markets and Companies
Date:11/30/2011

>Ophthalmic disorders 154

Introduction to gene therapy of ophthalmic disorders 154

Degenerative retinal disorders 155

Age-related macular degeneration 155

Inherited retinal degenerations 156

Inherited disorders affecting vision 157

Gene therapy for color blindness 157

Leber congenital amaurosis 157

Retinitis pigmentosa 158

Stargardt disease 159

Usher syndrome 159

X-linked juvenile retinoschisis 160

Proliferative retinopathies 160

Methods of gene transfer to retinal cells 160

DNA nanoparticles for nonviral gene transfer to the eye 161

Prevention of complications associated with eye surgery 162

Prevention of proliferative retinopathy by gene therapy 162

DNA nanoparticles for gene therapy of retinal degenerative disorders 162

Posterior capsule opacification after cataract surgery 162

Autoimmune uveitis 162

Retinal ischemic injury 163

Corneal disorders 163

Glaucoma 164

Disorders of hearing 164

Gene therapy for hearing loss 164

Organ transplantation 165

Introduction 165

DNA vaccines for transplantation 165

Gene therapy for prolonging allograft survival 165

Gene therapy in lung transplantation 166

Role of gene therapy in liver transplantation 166

Gene therapy in kidney transplantation 166

Veto cells and transplant tolerance 167

Pulmonary disorders 167

Techniques of gene delivery to the lungs 168

Adenoviral vectors 168

Non-viral vectors 169

Aerosolization as an aid to gene transfer to lungs. 169

Cystic fibrosis 170

Genetics and clinical features 170

Gene therapy for CF 170

CFTR gene transfer in CF 170

Concluding remarks about gene therapy of CF 172

Miscellaneous pulmonary disorders 172

Gene therapy for pulmonary arterial hypertension 172

Gene therapy for bleomycin
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