Navigation Links
Gene Signal Enters Phase III Clinical Tests for the Prevention of Corneal Graft Rejection

- Gene Signal International, a Biotech Company Registered in

Switzerland, Will Move its Headquarter to the EPFL, in Lausanne,

- Gene Signal is Addressing Various Issues Related to Neovascularisation,

- Gene Signal is Working on a Portfolio of Ophthalmologic Indications,

With One Now in Phase III Trials

- Gene Signal Will Present its Interim Results at the Annual Meeting of

the American Academy of Ophtalmologist in Atlanta, USA, the

Largest Scientific Convention in this Field

Gene Signal, a biotech company registered in Switzerland, is currently starting the Phase III study of GS-101, its most advanced therapeutic ophthalmic solution, for the prevention of corneal graft rejection.

Every year, over 40'000 corneal grafts are performed worldwide to cure or prevent blindness, thus making this procedure the most frequently performed transplant surgery. However, the 5 year failure rate for corneal grafts is currently around 35%. As many other graft procedures, donor grafts are always in limited supply. A failure is even more "wasteful" in this context of long waiting lines (6 months - 2 years).

One of the main reasons for graft failure is the immune response of the body. Normally, the cornea is avascular (i.e. deprived of blood vessels), protecting the donor cornea from being rejected. However, under certain circumstances, new blood vessel creation (neovascularization) occurs, inducing an immune response to the donor graft that can lead to immunological corneal graft rejection.

Currently, there is no therapy available. Gene Signal is working on new ways to prevent this syndrome. With its antisense oligonucleotide approach, it aims to block the pathways leading to the formation of blood vessels in the cornea. This approach uses short DNA fragments that specifically target and block the production of a protein that is required for the formation and growth of new blood vessels.

SOURCE Gene Signal International SA
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3

Related biology technology :

1. Revealing the regulating mechanism behind signal transduction in the brain
2. Signalife Announces Reverse Stock Split, Preferred Stock Dividend and $5 Million Investment
3. Signalife Announces Anticipated Date of Transition to OTCBB
4. Signalife to Issue Breaking News Regarding Vianale & Vianale Tomorrow
5. Signalife Announces Intent to Withdraw From AMEX and Trade on the OTCBB
6. AFL To Return to Oklahoma Due to Overwhelming Demand for Signalife Heart Screening
7. Signalife Board Approves Merger
8. Signalife Announces AFL Joins NIH Education Program
9. Signalife Appoints Lee Ehrlichman President and Chief Operating Officer
10. Signalife Appoints Lee Ehrlichman as Company Director and Operations Director; Additional Notice Received From Amex Regarding Sharholders Equity Deficiency
11. Signalife Awarded New U.S. Patent, System For, And Method Of, Monitoring Heartbeats Of A Patient
Post Your Comments:
(Date:3/3/2015)... , March 3, 2015 /CNW/- SQI Diagnostics Inc. (TSX:V: ... proprietary technologies and products for advanced microarray diagnostics, ... CA, CFE  to its Management team. In his ... in its transition from a development stage to ... to advance the Company,s capital market strategy and ...
(Date:3/3/2015)... , March 3, 2015  Regenicin, Inc. (OTC ... specializing in the development of and commercialization of regenerative ... and organs, announced today that it has received the ... Amarantus Bioscience Holdings, Inc. (OTC Bulletin Board: ... Agreement, Amarantus made the final payments due to Regenicin ...
(Date:3/3/2015)... March 3, 2015  RegeneRx Biopharmaceuticals, Inc. (OTCQB: RGRX) ... scientific journal, Expert Opinion on Biological Therapy , ... Zhenggang Zhang , at the Henry Ford Hospital ... Thymosin beta 4 (TB4) has the capacity to promote ... or more post-injury, leading to neurological recovery in each ...
(Date:3/3/2015)... FRANCISCO , March 3, 2015 Kindred Biosciences, ... on saving and improving the lives of pets, announced today ... financial results on March 12, 2015 after the market close. ... Eastern Time that day. Interested parties may ... US, or (484) 756-4262 internationally, and using conference ID 98449349.  ...
Breaking Biology Technology:SQI Diagnostics Appoints Chief Financial Officer 2SQI Diagnostics Appoints Chief Financial Officer 3Regenicin (RGIN) Receives $2.3 Million in Final Payment from Amarantus 2Regenicin (RGIN) Receives $2.3 Million in Final Payment from Amarantus 3Researchers at Henry Ford Hospital Propose Thymosin Beta 4 as Novel Way to Treat Neural Injury and Neurodegenerative Diseases 2Researchers at Henry Ford Hospital Propose Thymosin Beta 4 as Novel Way to Treat Neural Injury and Neurodegenerative Diseases 3
... 27 Neogen Corporation,(Nasdaq: NEOG ) ... agreement to become,the distributor of Chr. Hansen,s innovative ... poultry markets. , The ... offers for the swine and poultry markets, which ...
... of Life Science Research and Enables Experiment Modeling ... SIAL ) and Ingenuity Systems today launched ... biological search portal for exploring dynamic gene-based content ... library of research findings, Your Favorite Gene powered ...
... GeneGo, Inc., the leading systems biology tools company, announced ... of Glasgow will join the MetaMiner Stem Cell ... develop a series of blueprint pathway maps for Adult, ... Totipotent stem cells."We feel that it is important to ...
Cached Biology Technology:Neogen Named Supplier of Chr. Hansen Probiotics for Swine and Poultry 2Sigma-Aldrich Launches Your Favorite Gene Powered by Ingenuity 2Sigma-Aldrich Launches Your Favorite Gene Powered by Ingenuity 3Sigma-Aldrich Launches Your Favorite Gene Powered by Ingenuity 4University of Glasgow Becomes a Member of GeneGo's MetaMiner Stem Cell Partnership Program 2
(Date:2/25/2015)... , Feb. 25, 2015  ABC Financial ... billing in the Health and Fitness Industry, today ... as to MYiCLUBonline.  The latest upgrade includes advances ... inclusion of cardless check-in via Identity One fingerprint ... first time through interactive displays at the International ...
(Date:2/24/2015)... Feb. 24, 2015 This report analyzes the worldwide markets ... Segments: Face Biometrics, and Voice Biometrics. The report provides separate comprehensive ... Japan , Europe , Asia-Pacific ... Africa , and Latin America . Annual ... Also, a seven-year historic analysis is provided for these markets. Market ...
(Date:2/23/2015)... NXT-ID, Inc. (NASDAQ: NXTD ... company focused on the growing mobile commerce market, announced ... DISTRIBUTED VOICE DIRECTED PAYMENT METHOD AND SYSTEM. ... groundbreaking payment method. Payment accounts may be selected via ... accessed if both the speech (the word associated with ...
Breaking Biology News(10 mins):ABC Financial Unveils New Software Enhancements 2ABC Financial Unveils New Software Enhancements 3World Face and Voice Biometrics Industry 2World Face and Voice Biometrics Industry 3World Face and Voice Biometrics Industry 4World Face and Voice Biometrics Industry 5World Face and Voice Biometrics Industry 6World Face and Voice Biometrics Industry 7World Face and Voice Biometrics Industry 8World Face and Voice Biometrics Industry 9World Face and Voice Biometrics Industry 10World Face and Voice Biometrics Industry 11World Face and Voice Biometrics Industry 12World Face and Voice Biometrics Industry 13World Face and Voice Biometrics Industry 14World Face and Voice Biometrics Industry 15World Face and Voice Biometrics Industry 16NXT-ID Patents Voice Directed Payments 2NXT-ID Patents Voice Directed Payments 3
... led by University of Southern California (USC) professor Mary Ann ... friends drink alcohol are more likely to drink alcohol in ... appears in the September-October 2011 issue of the journal ... for alcohol use that may benefit from special prevention programs. ...
... Mothers, sisters and daughters from breast cancer families with ... risk of developing the disease, according to a new international ... the breast cancer genetic mutations BRCA1 or BRCA2 are at ... the average woman. The new study found that ...
... Poor sleep quality in both early and late pregnancy ... A study published in the Nov. 1 issue of ... preterm birth in women reporting sleep disruptions during their first ... factors and income levels were taken into account. "This ...
Cached Biology News:Underage drinking among close friends high indicator of future alcohol use by black teens 2Not all women in breast cancer families share high risk 2Poor sleep quality in first, third trimesters linked to preterm births 2
Rat Antibody to Mouse TCR VB8.1,8.2:FITC Recognises the V beta 8.1 and V beta 8.2 determinants of the murine T cell receptor. Specificity: mouse TCR VB8.1 and 8.2...
Vesicle Associated Membrane Protein (VAMP 1/2)...
Anti-Mouse Valpha 2 TCR, Purified (Clone B20.1) (rat IgG2a)...
Biology Products: