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Genaera Elects New Board Member and Announces Executive Appointments
Date:9/28/2007

n 2005, Dr. Wolfe has served in a number of capacities, most recently as Senior Vice President, Business Development and R&D. In this role, Dr. Wolfe will be continue to be responsible for business development, intellectual property and pharmacotoxicology research and development and will assume responsibility for manufacturing/CMC.

Dr. Gast joined Genaera in 2006, as Senior Vice President, Clinical Research and Development of Genaera. He will continue to utilize his clinical experience to effectively manage and drive all aspects of the Company's ongoing and future clinical programs, with particular focus on the trodusquemine (MSI-1436) clinical development program in obesity and type 2 diabetes.

About Genaera

Genaera Corporation is focused on advancing the science and treatment of metabolic diseases. The Company has significant market opportunities with a first-in-class molecule, trodusquemine (MSI-1436), that has the potential to redefine the treatment paradigm for obesity and type 2 diabetes and is presently in a Phase 1 trial in obesity. In addition, Genaera has a value-driven, fully out-licensed partnership with MedImmune, Inc. for a second core program that is presently undergoing Phase 2 clinical testing in asthma. Genaera is committed to directing resources to its core program and the aggressive clinical development of its key assets to build stockholder value. http://www.genaera.com.

This announcement contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 that are subject to risks and uncertainties, known and unknown. Forward-looking statements reflect management's current views and are based on certain expectations and assumptions. Such statements include, among others, statements regarding these preliminary results, clinical development plans and prospects for Genaera's programs including trodusquemine (MSI-1436), the IL-9 ant
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