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GenVec Announces Research on Improved Vaccine Vectors
Date:4/6/2012

GAITHERSBURG, Md., April 6, 2012 /PRNewswire/ -- GenVec, Inc. (NASDAQ:   GNVC) announced publication of research on GenVec's new vaccine vectors. These vectors circumvent neutralizing antibodies in order to generate the desired immunologic response. The paper has been published online in PloS ONE, and can be accessed at http://dx.plos.org/10.1371/journal.pone.0033920. The article titled "Modification of Ad5 Hexon Hypervariable Regions Circumvents Pre-existing Ad5 Neutralizing Antibodies and Induces Protective Immune Responses" is an example of GenVec's proprietary vaccine technology.

"This paper describes one of several new tools we are using to generate better vaccines," noted Douglas E. Brough, Ph.D., GenVec's Vice President of Research.  "This approach alters key elements of the vector so that a good vaccine response is generated even if an individual was previously exposed to an adenovirus.  This technology expands our genetic vaccine toolbox used to create superior vaccines."

About GenVec

GenVec is a biopharmaceutical company using differentiated, proprietary technologies to create superior therapeutics and vaccines. A key component of our strategy is to develop and commercialize our product candidates through collaborations. GenVec is working with leading companies and organizations such as Novartis, Merial, and the U.S. Government to support a portfolio of product programs that address the prevention and treatment of a number of significant human and animal health concerns. GenVec's development programs address therapeutic areas such as hearing loss and balance disorders; as well as vaccines against infectious diseases including respiratory syncytial virus (RSV), herpes simplex virus (HSV), dengue fever, malaria, and human immunodeficiency virus (HIV). In the area of animal health we are developing vaccines against foot-and-mouth disease (F
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