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GenOdyssee Receives Broad Product Applications Protection in EU for Founding Natural Evolution Technology
Date:10/24/2008

ed with HCV type 3 (genotype 3a) virus, in which GEA007.1 reduced

HCV RNA to levels 3-4 fold lower than IFN alpha 2 drugs.

- Stronger anti-HCV activity in vitro in the HCV genotype 1b

subgenomic replicon assay (BM4-5 cells) as compared to IFN alpha 2.

GEA007.1 exhibits a 7 fold superior inhibitory activity on HCV genotype

1b RNA synthesis compared to IFN alpha 2.

- Viral clearance of HCV genotype 1b replicon subgenome was

obtained in BM4-5 cells after long-term administration (20 days) of

GEA007.1, as evidenced by elimination of HCV genotype 1b RNA (both

strands) replicon genome. In contrast, HCV genotype 1b RNA (both strands)

was still apparent in cells treated with IFN alpha 2 in same conditions.

- No rebound of HCV genotype 1 replication after cessation of

GEA007.1 treatment. HCV subgenomic RNA remained undetectable after 5

passages post-treatment in GEA007.1 treated cells, whereas a low amount

of positive strand HCV subgenomic RNA was maintained in IFN alpha 2

treated cells.

- Similar safety pharmacology in rhesus monkeys (Macaca

mulatta) to IFN alpha 2.

- Importantly, GEA007.1 is a natural human protein, which

means it is already functional and tolerated in man.

CONTACT: Dr. Jean-Louis Escary, CEO

Tel: +33(0)616-416-857

Email: escary@genodyssee.com


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SOURCE GenOdyssee SA
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All rights reserved

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