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GenOdyssee Receives Broad Product Applications Protection in EU for Founding Natural Evolution Technology
Date:10/24/2008

confirms the uniqueness of our proprietary technology as well as the global leadership of our company's platform in the protein therapeutics optimization arena. There is potential to apply our technology to additional important classes of therapeutic cytokines such as Interleukins and CSFs," added Dr. Escary, chief executive officer.

The company's first lead product is a novel, natural human IFN alpha variant protein called GEA007.1, a protein which is found in all major human populations It is a naturally occurring variant of human IFN alpha 17, which incorporates an innovative amino acid substitution G45R that provides a novel positive charge together with a change in 3-D structure of the protein receptor binding site. The biochemical and structural modifications induced in the protein binding site provide for superior anti-HCV efficacy using the industry gold standard replicon assay without significantly increased toxicity as demonstrated in Rhesus Monkeys compared to standards of care IFN alpha 2 molecules. GEA007.1 product patent applications have been granted in the EU and in the USA and are pending in an additional 17 countries including Japan and emerging countries like China where HCV is also a major health problem.

Examination procedures by the international patent offices have not revealed any relevant prior art to such product or to the natural evolution technology invented by the company.

About GenOdyssee S.A.

GenOdyssee applies its proprietary population-genetics-based drug discovery approach using a proprietary DNA databank representative of more than 90% of the different ethnicities that constitute the current human population, which is screened for natural genetic variants of therapeutic proteins with superior pharmacological properties. The company pioneered the vision that natural evolution has led to the generation in the current population of unpredictable mutations that confer superior or novel therapeutic status to
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