period, a decrease of
75%. This decrease resulted primarily from the final installment of license
revenue under the Company's collaboration with bioMerieux, which was
recognized in the prior year period. For the full year 2007, royalty and
license revenues were $15.5 million, compared to $13.5 million in the prior
year, an increase of 15% that resulted primarily from $10.3 million of
royalty revenue that was recorded in the first quarter of 2007 associated
with the successful settlement of Gen-Probe's patent infringement claims
against Bayer HealthCare (now Siemens Healthcare Diagnostics).
Gross margin on product sales in the fourth quarter of 2007 was 69.2%,
compared to 67.6% in the prior year period. This increase resulted
primarily from reduced sales of lower-margin instrumentation compared to
the prior year period. For the full year 2007, gross margin on product
sales was 67.7%, compared to 68.1% in the prior year.
Research and development (R&D) expenses in the fourth quarter of 2007
were $24.3 million, compared to $20.7 million in the prior year period, an
increase of 17%. This increase resulted primarily from increased labor
costs and the timing of major R&D projects. These projects include assays
for human papillomavirus (HPV) and healthcare-associated infections, a
fully automated instrument system for low- and mid-volume laboratory
customers, and the post-marketing studies for the PROCLEIX ULTRIO(R) assay
in the United States. For the full year 2007, R&D expenses were $97.1
million, compared to $84.5 million in the prior year, an increase of 15%
that was due primarily to the factors described above.
Marketing and sales expenses in the fourth quarter of 2007 were $11.3
million, compared to $9.6 million in the prior year period, an increase of
18%. This increase resulted primarily from European market development
efforts related to the Company's investigational APTIMA HPV assay. For the
full year 2007, marketing and sales expenses were $
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