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Net cash provided by operating activities 67,520 32,928
Investing activities:
Proceeds from sales and maturities of short-term
investments 97,290 14,819
Purchases of short-term investments (181,546) (65,863)
Purchases of property, plant and equipment (20,033) (5,894)
Capitalization of intangible assets, including
license and manufacturing access fees (194) (1,817)
Sale of stock holdings of Molecular Profiling
Institute, Inc. 4,100 -
Other items, net 75 (352)
Net cash used in investing activities (100,308) (59,107)
Financing activities:
Repurchase and retirement of restricted stock for
payment of taxes (41) -
Excess tax benefit from employee stock options 145 1,284
Proceeds from issuance of common stock 3,027 4,402
Net cash provided by financing activities 3,131 5,686
Effect of exchange rate changes on cash and cash
equivalents (7) 16
Net decrease in cash and cash equivalents (29,664) (20,477)
Cash and cash equivalents at the beginning of
period 75,963 87,905
Cash and cash equivalents at the end of period $46,299 $67,428
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