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GNS Healthcare Joins Orion Bionetworks to Develop Predictive Models for Multiple Sclerosis and Other Diseases
Date:3/4/2013

xactly what this multidisciplinary group will provide for us," said Iya Khalil , Executive Vice President and Co-Founder of GNS Healthcare. "Working from rich databases of over 7,000 people with MS, GNS will be able to integrate clinical, biomarker, and imaging data to develop a causal, computational model of MS that has the promise to yield new insights into the underlying biology, and guide the development of more personalized courses of treatment for patients."

Orion Bionetworks will employ GNS Healthcare's REFS™ (Reverse Engineering and Forward Simulation) platform to reverse engineer computational models from MS data provided by Brigham and Women's Hospital, Accelerated Cure Project and PatientsLikeMe. Supercomputers and their powerful data-crunching capabilities have the capacity to analyze and understand the huge amounts of patient outcomes data that exist within the healthcare system. GNS's platform will utilize the untapped potential of that data to advance our understanding of the disease by expanding access to valuable biological and clinical data and providing new ways to interact with and apply the data.  Results from millions of in silico simulations will provide new insights into the fundamental mechanisms of MS, by finding the underlying causal relationships in the data. This, in turn, will help optimize treatment plans for patients.

"MS is a complicated condition for physicians to treat because it has various disease stages and a wide number of treatments. Currently we cannot predict an individual patient's optimal treatment course, and there is no personalization in the selection of treatments," said Philip De Jager , MD, PhD, a physician researcher at the Institute for Neurosciences at Brigham and Women's Hospital. "By connecting all of the available, but underutilized data with the supercomputing powe
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