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Further Analysis on Improved Genome Assembly Indicates the Outbreak E. coli has Complex Genetics With Resistance to at Least Eight Antibiotics
Date:6/4/2011

SHENZHEN, China, June 4, 2011 /PRNewswire/ -- To aid the fight of the deadly outbreak of E. coli O104 strain in Europe, BGI-Shenzhen and their collaborators at the University Medical Centre Hamburg-Eppendorf have released an updated draft genome assembly result built upon the sequencing data previously released and submitted to NCBI in the previous two days. As one of the first genomes assembled using the latest ion semiconductor sequencing technology, there were some initial difficulties assembling the genome, but a de novo assembly approach was applied first, and gene structures were refined with the assistance of genomic sequences from related strains.

This newly assembled draft genome is a large improvement on the previous version and is now freely accessible from the NCBI database (http://www.ncbi.nlm.nih.gov/bioproject/67657) and BGI website (ftp://ftp.genomics.org.cn/pub/Ecoli_TY-2482). The rapid release and dissemination of this data to the scientific community by the BGI, aided for the first time by new media forms such as Twitter (follow: @BGI_Events), has in less than 24-hours allowed researchers around the world to produce alternative genome assemblies, and now allows comparisons with additional, and potentially different isolates and strains (see: http://pathogenomics.bham.ac.uk/blog/2011/06/ehec-genome-assembly/).   This data should also aid in the development of diagnostic tests, as well as help to resolve issues regarding the outbreak's origin.

While preliminary, considerable additional information has been derived from this latest dataset in addition to that announced previously (see: http://www.genomics.cn/en/news_show.php?type=show&id=644). Based on th
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