Navigation Links
Full wired: Planar cell polarity genes guide gut neurons
Date:3/8/2013

The enteric nervous system (ENS), the "little brain" that resides within the gut wall, governs motility, secretion, and blood flow in the human gastrointestinal tract. Failure of the ENS to develop normally leads to congenital megacolon (Hirschsprung Disease) while loss of normal gut innervation is thought to contribute to debilitating motility disorders, such as irritable bowel syndrome. In order to prevent and treat these conditions, it is necessary to understand the molecular mechanisms that control the formation and function of the ENS. In this issue of the Journal of Clinial Investigation, Vassilis Pachnis and colleagues at the MRC National Institute for Medical Research in London found that the planar cell polarity (PCP) genes, Celsr3 and Fzd3 are required for the formation of the complex neural networks within the guts of mice. Inactivation of these genes resulted in disorganization of neuronal projections, slower gut transit time and abnormal colonic motility, indicating for the first time that improper ENS wiring contributes to gastrointestinal motility disorders. Future studies will be required to determine if mutations or dysfunction of these genes contributes to human gut motility disorders.


'/>"/>

Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

Page: 1

Related biology technology :

1. Genesis Biosystems Unveils Innovative Skin Treatment at Esthétique SPA International Trade Show
2. Scientists target bacterial transfer of resistance genes
3. Organogenesis Announces Annual College Scholarship Award Winner
4. Genesis Biopharma Mentioned Favorably in BioMedReports Article
5. Genesis Biopharma Issues Letter To Shareholders
6. Genesis Biopharma Announces Proposed Public Offering of Common Stock and Warrants
7. Autism mutations, scattered across many genes, merge into common network of interactions
8. ValGenesis Suite 2.5 Certified by SAP as Powered by SAP NetWeaver®
9. Weightlessness weighs heavy on genes a flys perspective
10. Scott Brooks Joins Regenesis Biomedical as Chief Operating Officer
11. ThermoGenesis Announces Approval of AXP® by India Ministry of Health
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/3/2016)... LONDON , May 3, 2016 ... Report Assessing Developers and Producers of Those Competitor Biologics  ... Guide to Companies, Activities and Prospects ,  ... drug companies? And what are their sales potentials? ... There you see results, trends, opportunities and revenue forecasting. ...
(Date:5/2/2016)... 2016 Q BioMed Inc. (QBIO), ... Mannin Research Inc. will be attending the Association for ... from May 1-5, 2016 in Seattle Washington ... its vendors and research partners. The meeting provides organizations ... other collaborative opportunities for the MAN-01 program for treatment ...
(Date:4/29/2016)... Como, Italy (PRWEB) , ... April 30, 2016 , ... ... their extraordinary textile design, the bioLogic team explored how bacterial properties can be applied ... ways of using Natto bacteria, which move in response to humidity change. The team ...
(Date:4/29/2016)... CO (PRWEB) , ... April 29, 2016 , ... ... addressing the necessary fundamentals to transform technology into a viable company, CereScan’s CEO, ... growth. Mr. Kelley, a recognized leader and mentor in the Denver area ...
Breaking Biology Technology:
(Date:4/28/2016)... -- First quarter 2016:   , Revenues ... first quarter of 2015 The gross margin was 49% ... and the operating margin was 40% (-13) Earnings per ... from operations was SEK 249.9 M (21.2) , Outlook ... 7,000-8,500 M. The operating margin for 2016 is estimated ...
(Date:4/15/2016)... Research and Markets has announced ... 2016-2020,"  report to their offering.  , ... global gait biometrics market is expected to grow ... 2016-2020. Gait analysis generates multiple variables ... to compute factors that are not or cannot ...
(Date:3/29/2016)... LegacyXChange, Inc. (OTC: LEGX ... Protect are pleased to announce our successful effort to ... of writing instruments, ensuring athletes signatures against counterfeiting and ... athletes on LegacyXChange will be assured of ongoing proof ... Bill Bollander , CEO states, "By inserting ...
Breaking Biology News(10 mins):