Navigation Links
Fruit fly steps in to fight human disease
Date:6/22/2009

"By putting mutant genes from human patients into fruit flies, we've created the first ever fly model for this kind of neuromuscular disease," says Albena Jordanova. "Now we have the opportunity to unravel the molecular mechanism behind Charcot-Marie-Tooth, as well as to start looking for substances with therapeutic value."

The breakthrough is the result of collaboration between VIB researchers working at the University of Antwerp and the Katholieke Universiteit Leuven, and appears in the Proceedings of the National Academy of Sciences (PNAS).

Charcot-Marie-Tooth is a hereditary disorder of the peripheral nervous system that affects 1 in 2,500 people worldwide. Patients suffer from progressive motor impairment, muscle wasting and weakness, sensory loss, and foot deformities. Affecting children and adults, the disease often starts with minor symptoms, gradually worsening over time. Presently CMT cannot be cured or prevented.

New chapter for an old gene

In previous research Albena Jordanova and Vincent Timmerman (VIB, University of Antwerp) discovered that CMT patients in families in Belgium, Bulgaria and the US showed three specific changes in one of the most ubiquitous genes in life: the YARS gene. YARS is responsible for the production of one of the oldest enzymes in the history of life (tyrosyl-tRNA synthetase), which is vital for the production of proteins. This was an entirely unexpected breakthrough. YARS had been considered a closed chapter in the biology textbooks. No one had suspected the relationship with specific variants of CMT until the revelation by Jordanova and her colleagues. These VIB findings open up an entirely new field of research.

Fruit flies with CMT symptoms

The VIB researchers at the University of Antwerp, in collaboration with Patrick Callaerts (VIB, K.U.Leuven) introduced four variants of the YARS gene into fruit flies. The normal variant, showed no difference in o
'/>"/>

Contact: Joris Gansemans
joris.gansemans@vib.be
32-472-594-067
VIB (the Flanders Institute for Biotechnology)
Source:Eurekalert

Page: 1 2

Related biology technology :

1. iNutrition Launches New Fission Fruit Nutrition Bars
2. Microsurgery on the brain of the fruit fly leads to new insights into irreparable nerve injuries
3. AMT CEO Ronald Lorijn Steps Down
4. Jonathan Lewis, M.D., Ph.D. Steps Down From Delcath Systems Board of Directors
5. Graphene pioneers follow in Nobel footsteps
6. Pharmaxis First Steps into China
7. Three Steps to Boost Asymchems Investment in China
8. Survey of More than 600 Patients Treated with Tracleer(R) (bosentan) Reveals Actelion Sure Steps(R) Patient Support Program Provides Valuable Educational Information
9. New White Paper Details Six Steps to Investigate and Prevent Laboratory Accidents
10. Yale scientists make 2 giant steps in advancement of quantum computing
11. New Survey Reveals Many Adults With High Cholesterol Fail to Take Necessary Steps to Improve Their Condition
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/26/2014)... 2014 Canada Endoscopy Visualization Systems ... on the Canada Endoscopy Visualization Systems market. The ... volume (in units) and average prices (in US ... Systems, Mid-Range Endoscopy Visualization Systems and Low-End Endoscopy ... http://www.marketresearchreports.biz/analysis/213254 . , The report also provides company ...
(Date:7/25/2014)... 26, 2014 "Ischemic Stroke and ... provides data on the Ischemic Stroke and Cerebral ... information and data relating to the clinical trials ... full global Ischemic Stroke Research Report 2014 at: ... of the trial numbers and their recruitment status ...
(Date:7/25/2014)... , July 25, 2014 Amgen (NASDAQ: ... today declared a $0.61 per share dividend for the ... on Sept. 5, 2014, to all stockholders of record ... 2014.  About Amgen Amgen is committed ... from serious illnesses by discovering, developing, manufacturing and delivering ...
(Date:7/25/2014)... -- Trillions of bacteria live in each person,s digestive ... digest food and stave off harmful infections, but their ... To help shed light on the role of these ... professor Eric Alm recently tracked fluctuations in the bacterial ... The findings, described in the July 25 issue of ...
Breaking Biology Technology:Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 2Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 3Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 4Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 5Ischemic Stroke and Cerebral Stroke Global Clinical Trials Review H2, 2014: MarketResearchReports.Biz 2Ischemic Stroke and Cerebral Stroke Global Clinical Trials Review H2, 2014: MarketResearchReports.Biz 3Amgen Announces 2014 Third Quarter Dividend 2Amgen Announces 2014 Third Quarter Dividend 3Monitoring the rise and fall of the microbiome 2Monitoring the rise and fall of the microbiome 3
... Educational program offers unique resources to empower transplant patients ... ... Oct. 17 Astellas Pharma US,Inc. (Pink Sheets: ALPMF), a ... Society (ITNS), a leading transplant,professional organization, announced a collaborative partnership ...
... to Dominate the Type 2 Diabetes Market, According to a ... New Report from Decision Resources, ... have released a new report finding that Merck,will obtain blockbuster antidiabetic ... uptake of their DPP-IV inhibitor, Januvia.,Januvia will see rapid uptake as ...
... 24, at 1:30 p.m. EDT, ALAMEDA, Calif., ... a biopharmaceutical company developing innovative therapies,for the treatment ... to discuss third quarter results on Wednesday, October ... Kenneth Chahine, Chief Executive,Officer, and Michael Coffee, Chief ...
Cached Biology Technology:Astellas Pharma US, Inc. and The International Transplant Nurses Society (ITNS) Collaborate on Content for Transplant Experience Program 2Astellas Pharma US, Inc. and The International Transplant Nurses Society (ITNS) Collaborate on Content for Transplant Experience Program 3Merck Will Obtain Blockbuster Antidiabetic Drug Sales in Type 2 Diabetes Market by 2011 2Merck Will Obtain Blockbuster Antidiabetic Drug Sales in Type 2 Diabetes Market by 2011 3Avigen, Inc. Announces Third Quarter 2007 Earnings Conference Call 2
(Date:7/25/2014)... N.Y., July 25, 2014 In the first broad-scale estimate ... Service scientists and collaborators calculated that trees are saving ... 670,000 incidences of acute respiratory symptoms. , While trees, ... of less than 1 percent, the impacts of that ... of the reduced air pollution at nearly $7 billion ...
(Date:7/25/2014)... 100,000s of people lived on the land now called ... control the availability of plants they used for food, ... fire to maintain desired habitat and natural resources. , ... Pacific Southwest Station, will lead a field trip ... the Ecological Society of America,s 99th Annual Meeting, in ...
(Date:7/25/2014)... this false-color image from the Terra satellite show the different ... wildfires in Eastern Russia. The burn scars show up ... The wildfires have broken across the remote parts of Eastern ... image from the MODIS instrument, it is still possible ... Two recent image features noted below show the devastating number ...
Breaking Biology News(10 mins):First national study finds trees saving lives, reducing respiratory problems 2Fire ecology manipulation by California native cultures 2Fire ecology manipulation by California native cultures 3
... 2012) Eye injuries in war have changed ... tactics, technology and strategies have evolved. Today,s soldiers ... areas not protected by body armor. Military experts and ... and Ear will convene in Boston, Mass., on Sept. ...
... almost $19 million will help to develop technologies ... the National Human Genome Research Institute (NHGRI), part ... During the past decade, DNA sequencing costs ... technologies and process improvements developed by genomics researchers. ...
... time this morning getting your shoes on or thinking about ... suffering with debilitating diseases such as ALS (Lou Gehrig,s disease) ... breathing and eating -- can be a struggle. They ... hopes to help through research that has just been funded ...
Cached Biology News:New NIH/NHGRI grants to harness nanoscale technologies to cut DNA sequencing costs 2New NIH/NHGRI grants to harness nanoscale technologies to cut DNA sequencing costs 3Neurobiologist Rodal wins New Innovator award 2
200 μg per ml DNA in 10 SSPE, 2 Denhardt's...
... Reacts with an early ... infection 3 hours post-infection exhibiting ... reaches peak intensity between 6-24 ... extremely intense coarsely granular staining. ...
... clone 8G8/5 GenBank Accession Number : ... AP-2alpha/gamma fusion protein corresponding to residues 166-223 ... human AP-2γ Formulation: 0.1M Tris-glycine, pH 7.4, ... addition of glycerol to 30% Quality Assurance: ...
Parathyroid Hormone Receptor 2 [PTHR2]...
Biology Products: