Navigation Links
Fruit fly steps in to fight human disease
Date:6/22/2009

"By putting mutant genes from human patients into fruit flies, we've created the first ever fly model for this kind of neuromuscular disease," says Albena Jordanova. "Now we have the opportunity to unravel the molecular mechanism behind Charcot-Marie-Tooth, as well as to start looking for substances with therapeutic value."

The breakthrough is the result of collaboration between VIB researchers working at the University of Antwerp and the Katholieke Universiteit Leuven, and appears in the Proceedings of the National Academy of Sciences (PNAS).

Charcot-Marie-Tooth is a hereditary disorder of the peripheral nervous system that affects 1 in 2,500 people worldwide. Patients suffer from progressive motor impairment, muscle wasting and weakness, sensory loss, and foot deformities. Affecting children and adults, the disease often starts with minor symptoms, gradually worsening over time. Presently CMT cannot be cured or prevented.

New chapter for an old gene

In previous research Albena Jordanova and Vincent Timmerman (VIB, University of Antwerp) discovered that CMT patients in families in Belgium, Bulgaria and the US showed three specific changes in one of the most ubiquitous genes in life: the YARS gene. YARS is responsible for the production of one of the oldest enzymes in the history of life (tyrosyl-tRNA synthetase), which is vital for the production of proteins. This was an entirely unexpected breakthrough. YARS had been considered a closed chapter in the biology textbooks. No one had suspected the relationship with specific variants of CMT until the revelation by Jordanova and her colleagues. These VIB findings open up an entirely new field of research.

Fruit flies with CMT symptoms

The VIB researchers at the University of Antwerp, in collaboration with Patrick Callaerts (VIB, K.U.Leuven) introduced four variants of the YARS gene into fruit flies. The normal variant, showed no difference in ordinary fruit flies. However, fruit flies with the mutant YARS genes, showed clear symptoms of CMT such as a reduced capacity to move, decreased functioning of the nerve cells and degeneration of the nerve endings.


'/>"/>

Contact: Joris Gansemans
joris.gansemans@vib.be
32-472-594-067
VIB (the Flanders Institute for Biotechnology)
Source:Eurekalert

Related biology technology :

1. iNutrition Launches New Fission Fruit Nutrition Bars
2. Microsurgery on the brain of the fruit fly leads to new insights into irreparable nerve injuries
3. AMT CEO Ronald Lorijn Steps Down
4. Jonathan Lewis, M.D., Ph.D. Steps Down From Delcath Systems Board of Directors
5. Graphene pioneers follow in Nobel footsteps
6. Pharmaxis First Steps into China
7. Three Steps to Boost Asymchems Investment in China
8. Survey of More than 600 Patients Treated with Tracleer(R) (bosentan) Reveals Actelion Sure Steps(R) Patient Support Program Provides Valuable Educational Information
9. New White Paper Details Six Steps to Investigate and Prevent Laboratory Accidents
10. Yale scientists make 2 giant steps in advancement of quantum computing
11. New Survey Reveals Many Adults With High Cholesterol Fail to Take Necessary Steps to Improve Their Condition
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2016)... ... December 01, 2016 , ... The Conference Forum has announced that the ... will take place on February 1-3, 2017 at the Roosevelt Hotel in New York ... program provides a unique 360-degree approach, which addresses the most up-to-date information regarding business ...
(Date:12/2/2016)...   SurePure, Inc. (OTCQB: SURP) a global ... has concluded an agreement with Tamarack Biotics under which ... to acquire units of the Company,s patented photopurification technology ... Concurrently with the option, SurePure has ... will seek regulatory approvals in the United ...
(Date:11/30/2016)... 30, 2016 The global Pyrogen ... hold a dominant share in the overall market. The ... Inc., and Merck KGaA, held a lion,s share of ... Research observes that these companies are expected to retain ... that are do not require rabbit pyrogen testing along ...
(Date:11/30/2016)... CHICAGO , Nov. 30, 2016  Tempus, ... customized cancer care, and Penn,s Abramson Cancer Center ... have a positive response to immunotherapy treatment based ... As part of a research collaboration, ... pancreatic and melanoma cancer patient data to Penn. ...
Breaking Biology Technology:
(Date:11/17/2016)... , Nov. 17, 2016  AIC announces that it has just released a ... organizations that require high-performance scale-out plus high speed data transfer storage solutions. ... ... ... Setting up a high performance ...
(Date:11/15/2016)... DUBLIN , Nov 15, 2016 Research ... - Global Forecast to 2021" report to their offering. ... ... reach USD 16.18 Billion by 2021 from USD 6.21 Billion in ... Growth of the bioinformatics market is driven by ...
(Date:6/27/2016)... Research and Markets has announced the addition of the "Biometrics ... The report forecasts the biometrics market ... CAGR of 12.28% during the period 2016-2020. The ... inputs from industry experts. The report covers the market landscape and ... a discussion of the key vendors operating in this market. ...
Breaking Biology News(10 mins):