Navigation Links
Fruit fly steps in to fight human disease

"By putting mutant genes from human patients into fruit flies, we've created the first ever fly model for this kind of neuromuscular disease," says Albena Jordanova. "Now we have the opportunity to unravel the molecular mechanism behind Charcot-Marie-Tooth, as well as to start looking for substances with therapeutic value."

The breakthrough is the result of collaboration between VIB researchers working at the University of Antwerp and the Katholieke Universiteit Leuven, and appears in the Proceedings of the National Academy of Sciences (PNAS).

Charcot-Marie-Tooth is a hereditary disorder of the peripheral nervous system that affects 1 in 2,500 people worldwide. Patients suffer from progressive motor impairment, muscle wasting and weakness, sensory loss, and foot deformities. Affecting children and adults, the disease often starts with minor symptoms, gradually worsening over time. Presently CMT cannot be cured or prevented.

New chapter for an old gene

In previous research Albena Jordanova and Vincent Timmerman (VIB, University of Antwerp) discovered that CMT patients in families in Belgium, Bulgaria and the US showed three specific changes in one of the most ubiquitous genes in life: the YARS gene. YARS is responsible for the production of one of the oldest enzymes in the history of life (tyrosyl-tRNA synthetase), which is vital for the production of proteins. This was an entirely unexpected breakthrough. YARS had been considered a closed chapter in the biology textbooks. No one had suspected the relationship with specific variants of CMT until the revelation by Jordanova and her colleagues. These VIB findings open up an entirely new field of research.

Fruit flies with CMT symptoms

The VIB researchers at the University of Antwerp, in collaboration with Patrick Callaerts (VIB, K.U.Leuven) introduced four variants of the YARS gene into fruit flies. The normal variant, showed no difference in ordinary fruit flies. However, fruit flies with the mutant YARS genes, showed clear symptoms of CMT such as a reduced capacity to move, decreased functioning of the nerve cells and degeneration of the nerve endings.


Contact: Joris Gansemans
VIB (the Flanders Institute for Biotechnology)

Related biology technology :

1. iNutrition Launches New Fission Fruit Nutrition Bars
2. Microsurgery on the brain of the fruit fly leads to new insights into irreparable nerve injuries
3. AMT CEO Ronald Lorijn Steps Down
4. Jonathan Lewis, M.D., Ph.D. Steps Down From Delcath Systems Board of Directors
5. Graphene pioneers follow in Nobel footsteps
6. Pharmaxis First Steps into China
7. Three Steps to Boost Asymchems Investment in China
8. Survey of More than 600 Patients Treated with Tracleer(R) (bosentan) Reveals Actelion Sure Steps(R) Patient Support Program Provides Valuable Educational Information
9. New White Paper Details Six Steps to Investigate and Prevent Laboratory Accidents
10. Yale scientists make 2 giant steps in advancement of quantum computing
11. New Survey Reveals Many Adults With High Cholesterol Fail to Take Necessary Steps to Improve Their Condition
Post Your Comments:
(Date:11/25/2015)... 25, 2015 /PRNewswire/ - Aeterna Zentaris Inc. (NASDAQ:  AEZS; ... and prospects remain fundamentally strong and highlights the ... recently received DSMB recommendation to continue the ZoptEC ... of the final interim efficacy and safety data ... in men with heavily pretreated castration- and Taxane-resistant ...
(Date:11/24/2015)... LUMPUR, Malaysia , Nov. 24, 2015 /PRNewswire/ ... global contract research organisation (CRO) market. The trend ... result in lower margins but higher volume share ... increased capacity and scale, however, margins in the ... Research Organisation (CRO) Market ( ), ...
(Date:11/24/2015)... ... November 24, 2015 , ... Copper is an ... is bound to proteins, copper is also toxic to cells. With a $1.3 ... Institute (WPI) will conduct a systematic study of copper in the bacteria Pseudomonas ...
(Date:11/24/2015)... ... November 24, 2015 , ... This fall, global software solutions leader ... five states to develop and pitch their BIG ideas to improve health and wellness ... competing for votes to win the title of SAP's Teen Innovator, an all-expenses paid ...
Breaking Biology Technology:
(Date:10/29/2015)... 2015 Daon, a global leader in mobile ... a new version of its IdentityX Platform , ... America have already installed IdentityX v4.0 and ... FIDO UAF certified server component as an ... FIDO features. These customers include some of the largest ...
(Date:10/29/2015)... 2015  Connected health pioneer, Joseph C. Kvedar ... technology-enabled health and wellness, and the business opportunities that ... The Internet of Healthy Things . Long before ... existed, Dr. Kvedar, vice president, Connected Health, Partners HealthCare, ... moving care from the hospital or doctor,s office into ...
(Date:10/29/2015)... Today, LifeBEAM , a leader ... a global leader in technical performance sports clothing ... advanced bio-sensing technology. The hat will allow fitness ... biometrics to improve overall training performance. As a ... bring together the most advanced technology, extensive understanding ...
Breaking Biology News(10 mins):